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This study evaluated the quorum sensing (QS)-inhibitory and anti-biofilm properties of a standardized pomegranate extract, as well as its major ellagitannins (punicalagin and ellagic acid), against Pseudomonas aeruginosa, an important opportunistic pathogen associated with multidrug-resistant infections. Using the P. aeruginosa strain (ATCC 27853) and the QS biosensor Chromobacterium violaceum, the pomegranate extract and punicalagin (MIC = 0.5 and 0.1 mg\/mL, respectively) suppressed the production of QS-regulated virulence factors (pyocyanin &amp;gt;80%, rhamnolipids &amp;gt;60%), inhibited bacterial motility, and disrupted biofilm formation (&amp;gt;70%) without inducing resistance. Cytotoxicity assays demonstrated the favorable cytocompatibility of the extract in mammalian cells. To enable localized delivery, a mechanically robust polyvinyl alcohol\u2013chitosan (PVA\u2013CS) hydrogel was developed. Structural characterization revealed a porous, hydrogen-bond-stabilized structure with enhanced thermal stability, favorable swelling behavior, and excellent moisture retention. Under simulated infection conditions, the extract-loaded hydrogel (P3C2P) significantly inhibited bacterial growth, attenuated virulence production, and suppressed both motility and biofilm formation. These findings demonstrate a triple-action anti-infective mechanism\u2014mediated by punicalagin, which concurrently targets virulence, motility, and biofilm formation. This work establishes a natural product-based hydrogel platform with significant translational potential for wound management and antimicrobial applications.<\/jats:p>","DOI":"10.1021\/acsabm.6c01343","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T19:02:06Z","timestamp":1788894126000},"page":"8828-8842","source":"Crossref","is-referenced-by-count":0,"title":["Hydrogel-Delivered Standardized Pomegranate (\n                    <i>Punica granatum<\/i>\n                    ) Extract Suppresses Quorum Sensing and Disrupts the Biofilm Structure in\n                    <i>Pseudomonas aeruginosa<\/i>"],"prefix":"10.1021","volume":"9","author":[{"given":"Sheng","family":"Lu","sequence":"first","affiliation":[{"name":"Central South University , , , ,","place":["Changsha, Hunan, China, 410078"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqian","family":"Wei","sequence":"additional","affiliation":[{"name":"Central South University , , , ,","place":["Changsha, Hunan, China, 410078"]},{"name":"Shuangliu Center for Disease Control and Prevention , , ,","place":["Chengdu, Sichuan, China, 610299"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Jiang","sequence":"additional","affiliation":[{"name":"Central South University , , , ,","place":["Changsha, Hunan, China, 410078"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danqi","family":"Wang","sequence":"additional","affiliation":[{"name":"Central South University , , , ,","place":["Changsha, Hunan, China, 410078"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Liu","sequence":"additional","affiliation":[{"name":"Central South University , , , ,","place":["Changsha, Hunan, China, 410078"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Hu","sequence":"additional","affiliation":[{"name":"Central South University , , , ,","place":["Changsha, Hunan, China, 410078"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Pharmacy, University of Rhode Island , , , ,","place":["Kingston, Rhode Island, USA, 02881"]},{"name":"The Second Affiliated Hospital of Soochow University , , ,","place":["Suzhou, China, 215004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7565-6889","authenticated-orcid":true,"given":"Hang","family":"Ma","sequence":"additional","affiliation":[{"name":"College of Pharmacy, University of Rhode Island , , , ,","place":["Kingston, Rhode Island, USA, 02881"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Ding","sequence":"additional","affiliation":[{"name":"Central South University , , , ,","place":["Changsha, Hunan, China, 410078"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5667-1426","authenticated-orcid":true,"given":"Tianhan","family":"Kai","sequence":"additional","affiliation":[{"name":"Central South University , , , ,","place":["Changsha, Hunan, China, 410078"]},{"name":"Furong Laboratory , , ,","place":["Changsha, Hunan, China, 410008"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"issue":"1","key":"2026092100091235900_cit1","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1038\/s41392-022-01056-1","article-title":"Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics","volume":"7","author":"Qin","year":"2022","journal-title":"Signal Transduct. 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