{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T08:56:46Z","timestamp":1790585806156,"version":"4.1.0"},"reference-count":35,"publisher":"American Chemical Society (ACS)","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22508280"],"award-info":[{"award-number":["22508280"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanxi Technology Innovation Center for Controlled and Sustained Release of Nanodrugs","award":["202104010911026"],"award-info":[{"award-number":["202104010911026"]}]},{"name":"Shanxi Province Basic Research Program","award":["202403021211065"],"award-info":[{"award-number":["202403021211065"]}]},{"name":"Shanxi Province Basic Research Program","award":["202403021221252"],"award-info":[{"award-number":["202403021221252"]}]},{"name":"Shanxi Province Basic Research Program","award":["202503021212009"],"award-info":[{"award-number":["202503021212009"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Biofilm-associated wound infections require antibacterial materials that can control attached bacteria while limiting excessive silver exposure. In this study, we prepared a sponge-like hierarchical porous silver\u2013carbon material through in situ glucose foaming and carbonization. The material had a Brunauer\u2013Emmett\u2013Teller surface area of 1067.8 m2 g\u20131 and a total silver content of 9.22% by weight after complete digestion. During dialysis against phosphate-buffered saline containing 1% bovine serum albumin, the material released approximately 0.27% of its total silver over 72 h. Comparative results showed differences in pore structure and silver transport but did not link release to a specific pore class. The porous silver\u2013carbon material inhibited Escherichia coli and Staphylococcus aureus. The minimum inhibitory and bactericidal concentrations were 4 and 8 \u03bcg mL\u20131, respectively, for Escherichia coli and 8 and 16 \u03bcg mL\u20131, respectively, for Staphylococcus aureus. Propidium iodide staining and scanning electron microscopy were consistent with increased membrane permeability and cell-surface damage. Assays using 2\u2032,7\u2032-dichlorodihydrofluorescein diacetate and electron spin resonance measurements supported reactive oxygen species-related stress. Plate-counting assays showed concentration-dependent inhibition of biofilm formation and reduced viable bacterial recovery from established biofilms. Murine fibroblast viability remained above 95%, and hemolysis remained below 5% under the tested conditions. In a full-thickness mouse wound model infected with Escherichia coli, the material and silver nitrate were applied at equal elemental silver doses of approximately 35 \u03bcg per wound. The material treatment yielded lower wound-derived colony counts per plate than the silver nitrate treatment on day 4 and reached approximately 95% wound closure by day 14. Endpoint histology showed no obvious structural abnormalities in the examined major organs. These findings suggest that pore structure, dialyzable-silver transport, and bacteria-material interactions should be considered together when designing porous silver\u2013carbon antibacterial materials.<\/jats:p>","DOI":"10.1021\/acsabm.6c01351","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T19:01:35Z","timestamp":1790535695000},"source":"Crossref","is-referenced-by-count":0,"title":["Hierarchically Porous Silver\u2013Carbon Composite with Dialyzable Silver Release for Biofilm Control and Healing of Infected Wounds"],"prefix":"10.1021","author":[{"given":"Sicong","family":"Yang","sequence":"first","affiliation":[{"name":"Taiyuan University of Technology , , ,","place":["Taiyuan, China, 030024"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Taiyuan University of Technology , , ,","place":["Taiyuan, China, 030024"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3220-7563","authenticated-orcid":true,"given":"Ziyang","family":"Shao","sequence":"additional","affiliation":[{"name":"Taiyuan University of Technology , , ,","place":["Taiyuan, China, 030024"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaowei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Third Hospital of Shanxi Medical University , , ,","place":["Taiyuan, China, 030032"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengwu","family":"Wang","sequence":"additional","affiliation":[{"name":"Taiyuan University of Technology , , ,","place":["Taiyuan, China, 030024"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Taiyuan University of Technology , , ,","place":["Taiyuan, China, 030024"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7470-1657","authenticated-orcid":true,"given":"Mei","family":"Niu","sequence":"additional","affiliation":[{"name":"Taiyuan University of Technology , , ,","place":["Taiyuan, China, 030024"]},{"name":"Taiyuan University of Technology , , ,","place":["Taiyuan, China, 030024"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoxia","family":"Xue","sequence":"additional","affiliation":[{"name":"Third Hospital of Shanxi Medical University , , ,","place":["Taiyuan, China, 030032"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Third Hospital of Shanxi Medical University , , ,","place":["Taiyuan, China, 030032"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongzhen","family":"Yang","sequence":"additional","affiliation":[{"name":"Taiyuan University of Technology , , ,","place":["Taiyuan, China, 030024"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Wang","sequence":"additional","affiliation":[{"name":"Taiyuan University of Technology , , ,","place":["Taiyuan, China, 030024"]},{"name":"Taiyuan University of Technology , , ,","place":["Taiyuan, China, 030024"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,27]]},"reference":[{"key":"2026092715012865900_cit1","doi-asserted-by":"publisher","first-page":"109","DOI":"10.3390\/biology13020109","article-title":"Bacterial Biofilm in Chronic Wounds and Possible Therapeutic Approaches","volume":"13","author":"Cavallo","year":"2024","journal-title":"Biology"},{"key":"2026092715012865900_cit2","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.13241","article-title":"Clinical management of chronic wound infections: The battle against biofilm","volume":"33","author":"Hurlow","year":"2025","journal-title":"Wound Repair Regen."},{"key":"2026092715012865900_cit3","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14667","article-title":"Biofilm therapy for chronic wounds","volume":"21","author":"Liu","year":"2024","journal-title":"Int. Wound J."},{"key":"2026092715012865900_cit4","doi-asserted-by":"publisher","first-page":"11883","DOI":"10.2147\/IJN.S484473","article-title":"How Nanoparticles Help in Combating Chronic Wound Biofilms Infection?","volume":"19","author":"Jing","year":"2024","journal-title":"Int. J. Nanomedicine"},{"key":"2026092715012865900_cit5","doi-asserted-by":"publisher","first-page":"283","DOI":"10.25270\/wnds\/24124","article-title":"Prevalence of Biofilm in Chronic Wounds: Systematic Review With Meta-Analysis","volume":"37","author":"Mendon\u00e7a Figueir\u00eado Coelho","year":"2025","journal-title":"Wounds"},{"key":"2026092715012865900_cit6","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1089\/wound.2023.0028","article-title":"Associations Among Wound-Related Factors Including Biofilm, Wound-Related Symptoms and Systemic Inflammation in Older Adults with Chronic Venous Leg Ulcers","volume":"13","author":"Kim","year":"2024","journal-title":"Adv. Wound Care"},{"key":"2026092715012865900_cit7","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuae002","article-title":"The role of human extracellular matrix proteins in defining Staphylococcus aureus biofilm infections","volume":"48","author":"Bhattacharya","year":"2024","journal-title":"FEMS Microbiol. Rev."},{"key":"2026092715012865900_cit8","doi-asserted-by":"publisher","first-page":"100906","DOI":"10.1016\/j.jpha.2023.11.013","article-title":"Contemporary strategies and approaches for characterizing composition and enhancing biofilm penetration targeting bacterial extracellular polymeric substances","volume":"14","author":"Lu","year":"2024","journal-title":"J. Pharm. Anal."},{"issue":"1","key":"2026092715012865900_cit9","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3390\/antibiotics14010005","article-title":"Green Silver Nanoparticles: An Antibacterial Mechanism","volume":"14","author":"Mikhailova","year":"2025","journal-title":"Antibiotics"},{"key":"2026092715012865900_cit10","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2025.1599113","article-title":"Silver nanoparticles as next-generation antimicrobial agents: mechanisms, challenges, and innovations against multidrug-resistant bacteria","volume":"15","author":"Khalifa","year":"2025","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"2026092715012865900_cit11","doi-asserted-by":"publisher","first-page":"801","DOI":"10.3390\/toxics12110801","article-title":"Effect of Silver Nanoparticle Size on Antibacterial Activity","volume":"12","author":"Ershov","year":"2024","journal-title":"Toxics"},{"key":"2026092715012865900_cit12","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.1337543","article-title":"Synergistic antibacterial mechanism of silver-copper bimetallic nanoparticles","volume":"11","author":"Hao","year":"2024","journal-title":"Front. Bioeng. Biotechnol."},{"key":"2026092715012865900_cit13","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202403913","article-title":"Hydrodynamics and Aggregation of Nanoparticles with Protein Corona: Effects of Protein Concentration and Ionic Strength","volume":"20","author":"Lee","year":"2024","journal-title":"Small"},{"key":"2026092715012865900_cit14","doi-asserted-by":"publisher","first-page":"757","DOI":"10.3390\/toxics12100757","article-title":"Oxidative Dissolution and the Aggregation of Silver Nanoparticles in Drinking and Natural Waters: The Influence of the Medium on the Process Development","volume":"12","author":"Ershov","year":"2024","journal-title":"Toxics"},{"key":"2026092715012865900_cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.chphi.2023.100445","article-title":"Formation of lipid corona on Ag nanoparticles and its impact on Ag+ ion dissolution and aggregation of Ag nanoparticles against external stimuli","volume":"8","author":"Maity","year":"2024","journal-title":"Chem. Phys. Impact"},{"key":"2026092715012865900_cit16","doi-asserted-by":"publisher","first-page":"18300","DOI":"10.1021\/acsami.3c15798","article-title":"Bactericidal Effect and Cytotoxicity of Graphene Oxide\/Silver Nanocomposites","volume":"16","author":"Durairaj","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"2026092715012865900_cit17","doi-asserted-by":"publisher","first-page":"4253","DOI":"10.2147\/IJN.S459176","article-title":"Single Atom-Dispersed Silver Incorporated in ZIF-8-Derived Porous Carbon for Enhanced Photothermal Activity and Antibacterial Activities","volume":"19","author":"Zheng","year":"2024","journal-title":"Int. J. Nanomedicine"},{"key":"2026092715012865900_cit18","doi-asserted-by":"publisher","first-page":"1857","DOI":"10.3390\/nano14221857","article-title":"Nano-Silver-Loaded Activated Carbon Material Derived from Waste Rice Noodles: Adsorption and Antibacterial Performance","volume":"14","author":"Ding","year":"2024","journal-title":"Nanomaterials"},{"key":"2026092715012865900_cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.162049","article-title":"Silver-loaded porous crystalline frameworks materials: A synergistic strategy for advanced antibacterial applications","volume":"511","author":"Li","year":"2025","journal-title":"Chem. Eng. J."},{"key":"2026092715012865900_cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.inoche.2024.113760","article-title":"Super porous cryogels loaded with silver nanoparticles: An effective antibacterial agent and catalyst for rapid reduction of dyes","volume":"173","author":"Fatima","year":"2025","journal-title":"Inorg. Chem. Commun."},{"key":"2026092715012865900_cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.inoche.2025.114934","article-title":"Microwave-assisted synthesis of silver nanoparticle-loaded carbon spheres and graphene oxide for antibacterial and hydrogen peroxide detection in aquaculture","volume":"180","author":"Phan","year":"2025","journal-title":"Inorg. Chem. Commun."},{"key":"2026092715012865900_cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2025.106640","article-title":"Efficacy of antibacterial and antibiofilm of silver nanoparticles decorated multi-walled carbon nanotubes loaded PF127 hydrogel","volume":"105","author":"Ryu","year":"2025","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"2026092715012865900_cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2024.120065","article-title":"Antibacterial and adsorption properties of silver-loaded carbon-sodium alginate-chitosan-soy protein isolate composite gel","volume":"222","author":"Cao","year":"2024","journal-title":"Ind. Crops Prod."},{"key":"2026092715012865900_cit24","doi-asserted-by":"publisher","first-page":"6565","DOI":"10.1007\/s10570-024-05996-5","article-title":"Synergistic carbon quantum dots and silver nanoparticles for self-cleaning and antibacterial cotton fibers","volume":"31","author":"Barani","year":"2024","journal-title":"Cellulose"},{"key":"2026092715012865900_cit25","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202304850","article-title":"Tunable Release of Ions from Graphene Oxide Laminates for Sustained Antibacterial Activity in a Biomimetic Environment","volume":"21","author":"Suran","year":"2025","journal-title":"Small"},{"key":"2026092715012865900_cit26","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202400047","article-title":"Silver Mineralized Protein Hydrogel with Intrinsic Cell Proliferation Promotion and Broad-Spectrum Antimicrobial Properties for Accelerated Infected Wound Healing","volume":"13","author":"Wang","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"2026092715012865900_cit27","doi-asserted-by":"publisher","first-page":"5165","DOI":"10.1515\/nanoph-2022-0523","article-title":"Mesoporous biophotonic carbon spheres with tunable curvature for intelligent drug delivery","volume":"11","author":"Fu","year":"2022","journal-title":"Nanophotonics"},{"key":"2026092715012865900_cit28","doi-asserted-by":"publisher","DOI":"10.1002\/celc.202200050","article-title":"Two-Dimensional Nitrogen-Doped Ti3C2 Promoted Catalysis Performance of Silver Nanozyme for Ultrasensitive Detection of Hydrogen Peroxide","volume":"9","author":"Zhu","year":"2022","journal-title":"ChemElectroChem"},{"key":"2026092715012865900_cit29","doi-asserted-by":"publisher","first-page":"5582","DOI":"10.1039\/D2TB00588C","article-title":"Biomimetic FeCo@PDA nanozyme platform with Fenton catalytic activity as efficient antibacterial agent","volume":"10","author":"Kuang","year":"2022","journal-title":"J. Mater. Chem. B"},{"key":"2026092715012865900_cit30","doi-asserted-by":"publisher","first-page":"3808","DOI":"10.1039\/d3tb00340j","article-title":"Phosphorene hydrogel conduits as \u201cneurotrophin reservoirs\u201d for promoting regeneration of peripheral nerves","volume":"11","author":"Hui","year":"2023","journal-title":"J. Mater. Chem. B"},{"key":"2026092715012865900_cit31","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202104607","article-title":"Nanopoxia: Targeting Cancer Hypoxia by Antimonene-Based Nanoplatform for Precision Cancer Therapy","volume":"31","author":"Qiu","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"2026092715012865900_cit32","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202102562","article-title":"A Regioselectively Oxidized 2D Bi\/BiOx Lateral Nano-Heterostructure for Hypoxic Photodynamic Therapy","volume":"33","author":"Qiu","year":"2021","journal-title":"Adv. Mater."},{"key":"2026092715012865900_cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2025.106964","article-title":"Green-synthesized carbon quantum dots\u2013silver nanocomposites for broad-spectrum antimicrobial and wound healing applications","volume":"108","author":"El Ghacham","year":"2025","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"2026092715012865900_cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2023.105194","article-title":"Enhanced in vivo wound healing efficacy and excellent antibacterial, antifungal, antioxidant and anticancer activities via AgNPs@PCS","volume":"16","author":"Zare-Bidaki","year":"2023","journal-title":"Arab. J. Chem."},{"key":"2026092715012865900_cit35","doi-asserted-by":"publisher","first-page":"5249","DOI":"10.1039\/D5SU00093A","article-title":"Antibiofilm efficacy of a green graphene oxide-silver nanocomposite against mixed microbial species biofilms: an in vitro and in silico approach","volume":"3","author":"Khan","year":"2025","journal-title":"RSC Sustainability"}],"container-title":["ACS Applied Bio Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsabm.6c01351","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/aabmcb\/article-pdf\/doi\/10.1021\/acsabm.6c01351\/68669604\/mt-2026-01351f.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/aabmcb\/article-pdf\/doi\/10.1021\/acsabm.6c01351\/68669604\/mt-2026-01351f.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T08:13:03Z","timestamp":1790583183000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/aabmcb\/article\/doi\/10.1021\/acsabm.6c01351\/5439519\/Hierarchically-Porous-Silver-Carbon-Composite-with"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,27]]},"references-count":35,"URL":"https:\/\/doi.org\/10.1021\/acsabm.6c01351","relation":{},"ISSN":["2576-6422"],"issn-type":[{"value":"2576-6422","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,27]]}}}