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However, most existing research is limited to a single antibacterial mechanism and may suffer from insufficient long-term efficacy, making it difficult to meet the requirements of large-scale production and applications in diverse scenarios. Therefore, the development of a synergistic, multi-mechanism antibacterial modification strategy for aluminum alloys is urgently needed. In this study, a dual-mechanism antibacterial aluminum alloy was developed by combining surface-structure-assisted antibacterial activity with ZnO-mediated antibacterial activity. By adjusting various process parameters, the surface roughness of the aluminum alloy and the microstructure of ZnO were regulated. This study systematically investigated the effects of aluminum-alloy surface roughness and ZnO microstructure on the antibacterial performance of the composite system. In vitro antibacterial test results showed that aluminum alloy subjected to the dual-mechanism modification exhibited excellent antibacterial activity: the antibacterial rate against E. coli and S. aureus reached 95 and 90%, respectively. This study provides a strategy to construct the dual-pathway synergistic antibacterial aluminum alloy, which possesses great potential in applications such as food processing, medical devices, and public health.<\/jats:p>","DOI":"10.1021\/acsabm.6c01369","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T22:01:36Z","timestamp":1790546496000},"page":"9786-9798","source":"Crossref","is-referenced-by-count":0,"title":["Design of Dual-Path Antibacterial Aluminum Alloy Based on ZnO Sputtering and Surface Roughness Control"],"prefix":"10.1021","volume":"9","author":[{"given":"Xia","family":"Luo","sequence":"first","affiliation":[{"name":"Shandong University , , ,","place":["Jinan, China, 250061"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijun","family":"Liu","sequence":"additional","affiliation":[{"name":"Shandong University , , ,","place":["Jinan, China, 250061"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqun","family":"Yao","sequence":"additional","affiliation":[{"name":"Shandong University , , ,","place":["Jinan, China, 250061"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Meng","sequence":"additional","affiliation":[{"name":"Shandong University , , ,","place":["Jinan, China, 250061"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunfu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Shandong Huang Shengtang Pharmaceutical Co., Ltd , ,","place":["Jinan, China, 250100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiwei","family":"Feng","sequence":"additional","affiliation":[{"name":"The Second Qilu Hospital of Shandong University , , ,","place":["Jinan, China, 250033"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Xue","sequence":"additional","affiliation":[{"name":"The Second Qilu Hospital of Shandong University , , ,","place":["Jinan, China, 250033"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7866-4689","authenticated-orcid":true,"given":"Yanyan","family":"Jiang","sequence":"additional","affiliation":[{"name":"The Second Qilu Hospital of Shandong University , , ,","place":["Jinan, People\u2019s Republic of China, 250033"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,27]]},"reference":[{"key":"2026101904081057300_cit1","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.jmst.2020.10.072","article-title":"Facile Li-Al Layered Double Hydroxide Films on Al Alloy for Enhanced Hydrophobicity, Anti-Biofouling and Anti-Corrosion Performance","volume":"79","author":"Li","year":"2021","journal-title":"J. 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