{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:12:56Z","timestamp":1789992776389,"version":"4.0.1"},"reference-count":24,"publisher":"American Chemical Society (ACS)","issue":"18","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100005089","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["L202041"],"award-info":[{"award-number":["L202041"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Methicillin-resistant Staphylococcus aureus (MRSA)-infected wounds remain difficult to treat because bacterial persistence, inflammation, antimicrobial resistance, and poorly controlled local toxicity can jointly impair tissue repair. Herein, we report an infection-responsive KCoF3@Fe-HA hydrogel that integrates potassium cobalt fluoride (KCoF3) with an Fe3+-crosslinked hyaluronic acid (HA) network for localized Co\/Fe dual Fenton-like antibacterial therapy. Notably, the use of KCoF3 in antibacterial wound dressing systems has not yet been reported. In this design, KCoF3 serves as a confined Co reservoir, while the Fe-HA network provides catalytic Fe species and a biodegradable hydrogel matrix. The introduction of Co-mediated Fenton-like activity may broaden the effective catalytic pH range and compensate for the limited activity of Fe-based Fenton-like systems under infection-relevant weakly acidic conditions. Meanwhile, the HA network provides infection responsiveness, allowing weak acidity and bacteria-associated hyaluronidase to promote localized network relaxation and degradation. Together with the reservoir-like KCoF3 structure, this design enables sustained Fe\/Co release around infected tissues, helping to maintain local antibacterial activity while reducing burst Co exposure and unnecessary metal leakage. KCoF3@Fe-HA showed stronger Fenton-like catalytic activity than single-metal hydrogel systems. The hydrogel exhibited broad-spectrum antibacterial activity against MRSA, Staphylococcus aureus (S. aureus), and Escherichia coli (E. coli) and effectively reduced bacterial burden in an MRSA-infected full-thickness wound model. Wounds treated with KCoF3@Fe-HA closed faster and showed weaker inflammatory signals, greater collagen deposition, and increased angiogenesis. Cytocompatibility, hemolysis, blood analysis, and major-organ histology supported its preliminary biosafety. This work provides a localized Co\/Fe Fenton-like dressing strategy for antibiotic-free MRSA-infected wound healing, presenting KCoF3 as a confined Co reservoir integrated with an infection-responsive HA hydrogel network.<\/jats:p>","DOI":"10.1021\/acsabm.6c01413","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T07:02:00Z","timestamp":1788764520000},"page":"8889-8898","source":"Crossref","is-referenced-by-count":0,"title":["An Infection-Responsive KCoF3@Fe-HA Hydrogel for Localized Co\/Fe Dual Fenton-like Therapy of MRSA-Infected Wounds"],"prefix":"10.1021","volume":"9","author":[{"given":"Yutong","family":"Liu","sequence":"first","affiliation":[{"name":"Capital Medical University , , ,","place":["Beijing, P.R. China, 100069"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghan","family":"Li","sequence":"additional","affiliation":[{"name":"Capital Medical University , , ,","place":["Beijing, P.R. China, 100069"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinzhan","family":"Li","sequence":"additional","affiliation":[{"name":"Capital Medical University , , ,","place":["Beijing, P.R. China, 100069"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifan","family":"Han","sequence":"additional","affiliation":[{"name":"Capital Medical University , , ,","place":["Beijing, P.R. China, 100069"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sizhang","family":"Li","sequence":"additional","affiliation":[{"name":"Capital Medical University , , ,","place":["Beijing, P.R. China, 100069"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianshuo","family":"Liu","sequence":"additional","affiliation":[{"name":"Capital Medical University , , ,","place":["Beijing, P.R. China, 100069"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanying","family":"Zhao","sequence":"additional","affiliation":[{"name":"Capital Medical University , , ,","place":["Beijing, P.R. China, 100069"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5047-9978","authenticated-orcid":true,"given":"Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"Capital Medical University , , ,","place":["Beijing, P.R. China, 100069"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5908-1616","authenticated-orcid":true,"given":"Wei","family":"Gu","sequence":"additional","affiliation":[{"name":"Capital Medical University , , ,","place":["Beijing, P.R. 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