{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:46:05Z","timestamp":1792784765078,"version":"4.5.0"},"reference-count":27,"publisher":"American Chemical Society (ACS)","issue":"20","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Natural Science Foundation of China (NSFC)","award":["22305177"],"award-info":[{"award-number":["22305177"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Natural Science Foundation of China (NSFC)","award":["22475154"],"award-info":[{"award-number":["22475154"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Natural Science Foundation of China (NSFC)","award":["52222306"],"award-info":[{"award-number":["52222306"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Wound healing involving persistent inflammation and fibrosis is driven by reactive oxygen species (ROS) and Yes-associated protein (YAP), often leading to scars. A polyvinyl alcohol\/alginate ultrasound-responsive hydrogel was developed, containing free epigallocatechin gallate (EGCG) in the matrix and EGCG-verteporfin (VP) nanoparticles embedded in the hydrogel network. Free EGCG is released rapidly, whereas EGCG-VP nanoparticles release is triggered by ultrasound. In vitro, this system reduced ROS by \u223c69%. Western blot revealed \u223c71% reduction in \u03b1-smooth muscle actin and \u223c47% in YAP. In vivo, it promoted wound closure in rats. This system enables programmable modulation of the wound microenvironment.<\/jats:p>","DOI":"10.1021\/acsabm.6c01430","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T07:01:42Z","timestamp":1790578902000},"page":"9471-9477","source":"Crossref","is-referenced-by-count":0,"title":["Ultrasound-Responsive Hydrogels for Accelerated Wound Healing through Programmable Microenvironment Modulation"],"prefix":"10.1021","volume":"9","author":[{"given":"Yue","family":"Ming","sequence":"first","affiliation":[{"name":"East China University of Science and Technology , , 130 Meilong Road , ,","place":["Shanghai, China, 200237"]},{"name":"Southern Medical University , , ,","place":["Guangzhou, China, 510280"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixing","family":"Chen","sequence":"additional","affiliation":[{"name":"East China University of Science and Technology , , 130 Meilong Road , ,","place":["Shanghai, China, 200237"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Jia","sequence":"additional","affiliation":[{"name":"Southern Medical University , , ,","place":["Guangzhou, China, 510280"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3025-8331","authenticated-orcid":true,"given":"Min","family":"Sun","sequence":"additional","affiliation":[{"name":"East China University of Science and Technology , , 130 Meilong Road , ,","place":["Shanghai, China, 200237"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1889-5669","authenticated-orcid":true,"given":"Jianzhong","family":"Du","sequence":"additional","affiliation":[{"name":"East China University of Science and Technology , , 130 Meilong Road , ,","place":["Shanghai, China, 200237"]},{"name":"Tongji University , , 4800 Caoan Road , ,","place":["Shanghai, China, 201804"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"issue":"8","key":"2026101904071429800_cit1","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/s41580-024-00715-1","article-title":"Cellular and Molecular Mechanisms of Skin Wound Healing","volume":"25","author":"Pe\u00f1a","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"38","key":"2026101904071429800_cit2","doi-asserted-by":"publisher","first-page":"50305","DOI":"10.1021\/acsami.4c09890","article-title":"Advanced Wound Healing and Scar Reduction Using an Innovative Anti-ROS Polysaccharide Hydrogel with Recombinant Human Collagen Type III","volume":"16","author":"Zhang","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"1","key":"2026101904071429800_cit3","doi-asserted-by":"publisher","DOI":"10.1002\/exp.20240517","article-title":"Scar Inhibition in Wound Healing: Mechanisms, Design, and Recent Advances","volume":"6","author":"Kang","year":"2026","journal-title":"Exploration"},{"issue":"1","key":"2026101904071429800_cit4","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1038\/s41392-022-01191-9","article-title":"The Hippo Signalling Pathway and its Implications in Human Health and Diseases","volume":"7","author":"Fu","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"issue":"4","key":"2026101904071429800_cit5","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1152\/physrev.00005.2014","article-title":"The Biology of YAP\/TAZ: Hippo Signaling and Beyond","volume":"94","author":"Piccolo","year":"2014","journal-title":"Physiol. Rev."},{"key":"2026101904071429800_cit6","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.freeradbiomed.2024.01.003","article-title":"Verteporfin Induces Lipid Peroxidation and Ferroptosis in Pancreatic Cancer Cells","volume":"212","author":"Zhou","year":"2024","journal-title":"Free Radical Biol. Med."},{"issue":"786","key":"2026101904071429800_cit7","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adt6387","article-title":"Inhibiting Mechanotransduction Prevents Scarring and Yields Regeneration in a Large Animal Model","volume":"17","author":"Mascharak","year":"2025","journal-title":"Sci. Transl. Med."},{"issue":"1","key":"2026101904071429800_cit8","doi-asserted-by":"publisher","first-page":"7099","DOI":"10.1038\/s41467-025-61795-x","article-title":"Inhibition of Epithelial Cell YAP-TEAD\/LOX Signaling Attenuates Pulmonary Fibrosis in Preclinical Models","volume":"16","author":"Wagner","year":"2025","journal-title":"Nat. Commun."},{"issue":"16","key":"2026101904071429800_cit9","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202100477","article-title":"Wound Healing: From Passive to Smart Dressings","volume":"10","author":"Farahani","year":"2021","journal-title":"Adv. Healthcare Mater."},{"issue":"8","key":"2026101904071429800_cit10","doi-asserted-by":"publisher","first-page":"12687","DOI":"10.1021\/acsnano.1c04206","article-title":"Functional Hydrogels as Wound Dressing to Enhance Wound Healing","volume":"15","author":"Liang","year":"2021","journal-title":"ACS Nano"},{"issue":"1","key":"2026101904071429800_cit11","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s40779-024-00519-6","article-title":"Biomaterial-Based Mechanical Regulation Facilitates Scarless Wound Healing with Functional Skin Appendage Regeneration","volume":"11","author":"Li","year":"2024","journal-title":"Mil. Med. Res."},{"issue":"47","key":"2026101904071429800_cit12","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.75467","article-title":"Orbital Coupling-Induced Ce\u2013Cu Heterogeneous Dual-Single-Atom Hybrid for Programmable and Adaptive Catalytic Therapy of Diabetic Wounds","volume":"36","author":"Sun","year":"2026","journal-title":"Adv. Funct. Mater."},{"issue":"23","key":"2026101904071429800_cit13","doi-asserted-by":"publisher","first-page":"24055","DOI":"10.1021\/acsnano.3c09034","article-title":"A Versatile Hydrogel with Antibacterial and Sequential Drug-Releasing Capability for the Programmable Healing of Infectious Keratitis","volume":"17","author":"Meng","year":"2023","journal-title":"ACS Nano"},{"key":"2026101904071429800_cit14","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.bioactmat.2026.02.043","article-title":"Smart Microenvironment-Adaptive Nanocatalytic Hydrogel for Sequential Antibacterial, Anti-Inflammatory, and Regenerative Therapy of Biofilm-Infected Wounds","volume":"62","author":"Zhang","year":"2026","journal-title":"Bioact. Mater."},{"issue":"6","key":"2026101904071429800_cit15","doi-asserted-by":"publisher","first-page":"1852","DOI":"10.1021\/acs.molpharmaceut.6b01015","article-title":"Leveraging Colloidal Aggregation for Drug-Rich Nanoparticle Formulations","volume":"14","author":"Ganesh","year":"2017","journal-title":"Mol. Pharmaceutics"},{"key":"2026101904071429800_cit16","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/j.ijbiomac.2018.11.095","article-title":"Preparation and Characterization of Porous Starch Reinforced with Halloysite Nanotube by Solvent Exchange Method","volume":"123","author":"Oliyaei","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"issue":"24","key":"2026101904071429800_cit17","doi-asserted-by":"publisher","first-page":"12347","DOI":"10.1039\/d1fo03099j","article-title":"Sodium Alginate\/Soybean Protein\u2013Epigallocatechin-3-Gallate Conjugate Hydrogel Beads: Evaluation of Structural, Physical, and Functional Properties","volume":"12","author":"Hu","year":"2021","journal-title":"Food Funct."},{"issue":"Pt 4","key":"2026101904071429800_cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.134956","article-title":"Multifunctional Chitosan-Based Composite Hydrogels Engineered for Sensing Applications","volume":"278","author":"Ren","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"2026101904071429800_cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.119003","article-title":"Freeze-Thaw and Solvent-Exchange Strategy to Generate Physically Cross-Linked Organogels and Hydrogels of Curdlan with Tunable Mechanical Properties","volume":"278","author":"Wu","year":"2022","journal-title":"Carbohydr. Polym."},{"issue":"33","key":"2026101904071429800_cit20","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adh4327","article-title":"Injectable, Self-Healing Hydrogel Adhesives with Firm Tissue Adhesion and on-Demand Biodegradation for Sutureless Wound Closure","volume":"9","author":"Ren","year":"2023","journal-title":"Sci. Adv."},{"key":"2026101904071429800_cit21","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1016\/j.ijbiomac.2019.05.143","article-title":"Preparation and Antioxidant Activity of Sodium Alginate and Carboxymethyl Cellulose Edible Films with Epigallocatechin Gallate","volume":"134","author":"Ruan","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"2026101904071429800_cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120418","article-title":"Epigallocatechin Gallate Mediated Sandwich-Like Coating for Mimicking Endothelium with Sustained Therapeutic Nitric Oxide Generation and Heparin Release","volume":"269","author":"Zhang","year":"2021","journal-title":"Biomaterials"},{"issue":"8050","key":"2026101904071429800_cit23","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/s41586-024-08401-0","article-title":"H-Bonded Organic Frameworks as Ultrasound-Programmable Delivery Platform","volume":"638","author":"Wang","year":"2025","journal-title":"Nature"},{"key":"2026101904071429800_cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultsonch.2020.105143","article-title":"Ultrasound Response of Viscoelastic Changes of Cellulose Hydrogels Triggered with Sono-Deviced Rheometer","volume":"67","author":"Noguchi","year":"2020","journal-title":"Ultrason. Sonochem."},{"issue":"18","key":"2026101904071429800_cit25","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202307630","article-title":"Turmeric-Derived Nanoparticles Functionalized Aerogel Regulates Multicellular Networks to Promote Diabetic Wound Healing","volume":"11","author":"Wu","year":"2024","journal-title":"Adv. Sci."},{"issue":"4","key":"2026101904071429800_cit26","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1111\/j.1524-475x.2007.00256.x","article-title":"Creating Thick Linear Scar by Inserting a Gelatin Sponge into Rat Excisional Wounds","volume":"15","author":"Wu","year":"2007","journal-title":"Wound Repair Regen."},{"issue":"12","key":"2026101904071429800_cit27","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1101\/gad.192856.112","article-title":"Genetic and Pharmacological Disruption of the TEAD\u2013YAP Complex Suppresses the Oncogenic Activity of YAP","volume":"26","author":"Liu-Chittenden","year":"2012","journal-title":"Genes Dev."}],"container-title":["ACS Applied Bio Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsabm.6c01430","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/aabmcb\/article-pdf\/9\/20\/9471\/68672022\/mt-2026-01430a.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/aabmcb\/article-pdf\/9\/20\/9471\/68672022\/mt-2026-01430a.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T08:29:34Z","timestamp":1792398574000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/aabmcb\/article\/9\/20\/9471\/5439665\/Ultrasound-Responsive-Hydrogels-for-Accelerated"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,28]]},"references-count":27,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2026,9,28]]},"published-print":{"date-parts":[[2026,10,19]]}},"URL":"https:\/\/doi.org\/10.1021\/acsabm.6c01430","relation":{},"ISSN":["2576-6422"],"issn-type":[{"value":"2576-6422","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,28]]}}}