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AuNS@SiO2 exhibited a plasmonic band centered at 810 nm, positive \u03b6-potential (+32.62 mV), and preserved photothermal activity, reaching 38.56 \u00b1 1.79 \u00b0C under 810 nm irradiation, with a temperature increase of 14.71 \u00b1 1.16 \u00b0C. In Caco-2 cells, AuNS@SiO2 showed limited dark toxicity up to 160 \u03bcg mL\u20131, with cell viability remaining above 94%, whereas NIR irradiation sharply reduced viability to 14.9 and 4.82% at 267 and 400 \u03bcg mL\u20131, respectively. In contrast, HT-29 cells were more sensitive to AuNS@SiO2 in the absence of irradiation, with viability decreasing to 38.0 and 28.1% at the same concentrations, indicating a stronger contact-associated response. Cell-derived Langmuir lipid models supported this interpretation: at 30 mN m\u20131, AuNS@SiO2 induced larger relative area expansions in HT-29 models, reaching 34.87 \u00b1 1.04% at the 1:1 ratio, compared with 17.67 \u00b1 1.16% for Caco-2. FTIR analysis showed that nanoparticle interaction mainly affected polar headgroup and interfacial regions, while the lipid acyl-chain region remained largely preserved. Together, these findings indicate that AuNS@SiO2 elicit cell-line-dependent phototoxic profiles associated with membrane-related interactions, with Caco-2 displaying a predominantly light-amplified response and HT-29 showing a more contact-dominated response.<\/jats:p>","DOI":"10.1021\/acsabm.6c01490","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:02:32Z","timestamp":1791306152000},"page":"9844-9858","source":"Crossref","is-referenced-by-count":0,"title":["Membrane-Associated Phototoxicity of Silica-Coated Gold Nanostars in Colorectal Cancer Cells"],"prefix":"10.1021","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0998-650X","authenticated-orcid":true,"given":"Andr\u00e9 Satoshi","family":"Ferreira","sequence":"first","affiliation":[{"name":"S\u00e3o Paulo State University (UNESP), School of Sciences, Humanities and Languages , , ,","place":["Assis, SP, Brazil, 19806-900"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3089-060X","authenticated-orcid":true,"given":"Bruna Alves","family":"Martins","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University (UNESP), School of Sciences, Humanities and Languages , , ,","place":["Assis, SP, Brazil, 19806-900"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1004-1454","authenticated-orcid":true,"given":"Giovanna Eller Silva","family":"Sousa","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University (UNESP), School of Sciences, Humanities and Languages , , ,","place":["Assis, SP, Brazil, 19806-900"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9588-1115","authenticated-orcid":true,"given":"Melissa Nishida","family":"Hirano","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University (UNESP), School of Sciences, Humanities and Languages , , ,","place":["Assis, SP, Brazil, 19806-900"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6590-759X","authenticated-orcid":true,"given":"Sabrina Al\u00e9ssio","family":"Camacho","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University (UNESP), School of Sciences, Humanities and Languages , , ,","place":["Assis, SP, Brazil, 19806-900"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina Alves","family":"Toledo","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University (UNESP), School of Sciences, Humanities and Languages , , ,","place":["Assis, SP, Brazil, 19806-900"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4701-6408","authenticated-orcid":true,"given":"Pedro Henrique Benites","family":"Aoki","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University (UNESP), School of Sciences, Humanities and Languages , , ,","place":["Assis, SP, Brazil, 19806-900"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"2026101904075617400_cit1","doi-asserted-by":"publisher","first-page":"6","DOI":"10.37349\/emed.2025.1001371","article-title":"Colorectal Cancer Worldwide: Epidemiological Trends, Economic Burden, and the Promise of AI-Driven Solutions","author":"Le","year":"2025","journal-title":"Explor. 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