{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:44:09Z","timestamp":1792784649732,"version":"4.5.0"},"reference-count":45,"publisher":"American Chemical Society (ACS)","issue":"18","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"name":"Key Research and Development Program of Ningxia Hui Autonomous Region","award":["2026BEG02026"],"award-info":[{"award-number":["2026BEG02026"]}]},{"name":"Prevention and Control of Emerging and Major Infectious Diseases-National Science and Technology Major Project","award":["2026ZD01913000"],"award-info":[{"award-number":["2026ZD01913000"]}]},{"name":"National Natural Science Foundation of China (NSFC)","award":["82272248"],"award-info":[{"award-number":["82272248"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Natural Science Foundation of China (NSFC)","award":["82322042"],"award-info":[{"award-number":["82322042"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chronic hepatitis B (CHB) afflicts approximately 254 million people worldwide and is responsible for more than one million deaths annually. Intrahepatic persistence of covalently closed circular DNA (cccDNA), the episomal transcriptional template of hepatitis B virus (HBV), sustains chronic replication, blunts the efficacy of antiviral therapy, and precipitates virological relapse once treatment is discontinued. While emerging cccDNA-targeted strategies include CRISPR\/Cas9-mediated cleavage and epigenetic silencing, their clinical translation is impeded by delivery inefficiency, safety concerns, and limited durability. Herein, we present a sequential nano-therapeutic platform that combines small interfering RNA (siRNA) delivery using HBV-pre-activated macrophage membranes (HMs) with photothermal therapy utilizing aggregation-induced emission (AIE) agents. In the first step, HM-coated lipid nanoparticles encapsulating siRNA (siR@HM NPs) enable virus to neutralize and hepatocyte targeted delivery via surface viral receptors, achieving efficient gene silencing. At 72 h post-administration, HM-coated PLGA nanoparticles loaded with an AIE photothermal agent (TPAT@HM NPs) are introduced, facilitating near-infrared IIb fluorescence-guided 808 nm laser ablation of residual infected cells. In a cell model of chronic HBV infection, both siR@HM NPs and TPAT@HM NPs achieved targeted delivery to infected hepatocytes. Critically, sequential administration yielded superior antiviral efficacy compared with concurrent administration or either monotherapy, leading to substantial reduction in HBsAg, HBeAg, HBV DNA, cccDNA, and pgRNA levels. Biosafety assessments confirmed negligible cytotoxicity, hemolysis, and systemic toxicity. This bionic platform integrates time-programmed virus targeting, RNA interference, and photothermal ablation. The virus-preactivated membrane coating enables dual recognition of both viral particles and infected cells, offering a precise and scalable theranostic strategy for HBV and other refractory viral infections.<\/jats:p>","DOI":"10.1021\/acsabm.6c01518","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T17:02:02Z","timestamp":1788886922000},"page":"8959-8970","source":"Crossref","is-referenced-by-count":0,"title":["Sequential Precise Targeted Hepatitis B Virus Therapy: Hepatitis B Virus-Specific Small Interfering RNA Followed by Aggregation-Induced Emission-Photothermal Ablation Based on Macrophage Membrane-Coated Nanoplatform"],"prefix":"10.1021","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3212-1067","authenticated-orcid":true,"given":"Zihui","family":"Wei","sequence":"first","affiliation":[{"name":"Southern Medical University (Guangdong Provincial Key Laboratory of Tropical Disease Research) , , , ,","place":["Guangzhou, Guangdong, China, 510515"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixia","family":"Gao","sequence":"additional","affiliation":[{"name":"Southern Medical University (Guangdong Provincial Key Laboratory of Tropical Disease Research) , , , ,","place":["Guangzhou, Guangdong, China, 510515"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengting","family":"Zheng","sequence":"additional","affiliation":[{"name":"Southern Medical University (Guangdong Provincial Key Laboratory of Tropical Disease Research) , , , ,","place":["Guangzhou, Guangdong, China, 510515"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Wang","sequence":"additional","affiliation":[{"name":"Southern Medical University (Guangdong Provincial Key Laboratory of Tropical Disease Research) , , , ,","place":["Guangzhou, Guangdong, China, 510515"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinting","family":"Fu","sequence":"additional","affiliation":[{"name":"Southern Medical University (Guangdong Provincial Key Laboratory of Tropical Disease Research) , , , ,","place":["Guangzhou, Guangdong, China, 510515"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Duan","sequence":"additional","affiliation":[{"name":"Southern Medical University (Guangdong Provincial Key Laboratory of Tropical Disease Research) , , , ,","place":["Guangzhou, Guangdong, China, 510515"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiamei","family":"Wang","sequence":"additional","affiliation":[{"name":"Kunming Medical University , , , ,","place":["Kunming, Yunnan, China, 650500"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqiu","family":"Wu","sequence":"additional","affiliation":[{"name":"Southern Medical University , , , ,","place":["Guangzhou, Guangdong, China, 510515"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Ma","sequence":"additional","affiliation":[{"name":"Ningxia Medical University , , , ,","place":["Yinchuan, Ningxia, China, 750004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Southern Medical University , , , ,","place":["Guangzhou, Guangdong, China, 510515"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Jia","sequence":"additional","affiliation":[{"name":"Ningxia Medical University , , , ,","place":["Yinchuan, Ningxia, China, 750004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Gu","sequence":"additional","affiliation":[{"name":"Ningxia Medical University , , , ,","place":["Yinchuan, Ningxia, China, 750004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changting","family":"He","sequence":"additional","affiliation":[{"name":"Ningxia Medical University , , , ,","place":["Yinchuan, Ningxia, China, 750004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongli","family":"Wang","sequence":"additional","affiliation":[{"name":"Kunming Medical University , , , ,","place":["Kunming, Yunnan, China, 650500"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[{"name":"Ningxia Medical University , , , ,","place":["Yinchuan, Ningxia, China, 750004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifeng","family":"Ma","sequence":"additional","affiliation":[{"name":"Southern Medical University (Guangdong Provincial Key Laboratory of Tropical Disease Research) , , , ,","place":["Guangzhou, Guangdong, China, 510515"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4702-9516","authenticated-orcid":true,"given":"Yuhui","family":"Liao","sequence":"additional","affiliation":[{"name":"Ningxia Medical University , , , ,","place":["Yinchuan, Ningxia, China, 750004"]},{"name":"Kunming Medical University , , , ,","place":["Kunming, Yunnan, China, 650500"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"issue":"5","key":"2026092100085617600_cit1","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1097\/hep.0000000000001260","article-title":"Global burden of HBV-related liver disease: Primary liver cancer due to chronic HBV infection increased in over one-third of countries globally from 2000 to 2021","volume":"82","author":"Danpanichkul","year":"2000","journal-title":"Hepatology"},{"issue":"3","key":"2026092100085617600_cit2","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.jhep.2025.09.033","article-title":"HBx-induced HSPB1 is a potential therapeutic target owing to its modulation of HBV cccDNA and hepatic immune responses","volume":"84","author":"Yuan","year":"2026","journal-title":"J. Hepatol."},{"issue":"5","key":"2026092100085617600_cit3","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1016\/j.jhep.2025.11.017","article-title":"A genome-wide siRNA screen identifies previously unknown proviral and antiviral host factors in HBV infection","volume":"84","author":"Cheng","year":"2026","journal-title":"J. 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