{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:49:19Z","timestamp":1791413359668,"version":"4.3.3"},"reference-count":66,"publisher":"American Chemical Society (ACS)","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Department of Biotechnology , Ministry of Science and Technology","award":["BT\/PR\/14187\/BRB\/10\/ 1413\/2015"],"award-info":[{"award-number":["BT\/PR\/14187\/BRB\/10\/ 1413\/2015"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Aloe-emodin (AED), a naturally occurring anthraquinone, was examined for its interaction with two model human telomeric G-quadruplex systems: wHTel26 adopting a hybrid-2 topology in K+-containing buffer and HTel22 adopting an antiparallel basket topology in Na+-containing buffer. UV\u2013visible absorption, fluorescence, and circular dichroism spectroscopy showed concentration-dependent changes consistent with AED association with both G4 models. The apparent binding constants varied among the analytical techniques, spanning approximately 103 M\u20131\u2013105 M\u20131, reflecting the distinct optical and conformational observables monitored by each method and the non-linear nature of the titration profiles. The limited wavelength shifts and preservation of the major CD signatures were consistent with a non-intercalative interaction, although the precise binding geometry and stoichiometry could not be resolved. AED produced an apparent thermal stabilization of approximately 14 \u00b0C for wHTel26 under the tested K+ condition, whereas no comparable stabilization was observed for HTel22 under the tested Na+ condition. Because the systems differed simultaneously in sequence, flanking residues, topology, and cation, this difference cannot be attributed solely to the ionic environment. Docking generated plausible AED association poses was used only as supportive, hypothesis-generating evidence. AED also reduced MCF-7 metabolic viability with an estimated IC50 of 18.82 \u00b5M; however, telomerase inhibition and intracellular G4 target engagement were not investigated. Thus, establishing sequence- and cation-controlled G4 selectivity and confirming intracellular target engagement remain important challenges. Future studies employing matched-sequence\/cross-cation comparisons, direct cellular G4-target engagement, and telomerase-based mechanistic assays will be required to establish the molecular and biological significance of AED\u2013G4 interactions.<\/jats:p>","DOI":"10.1021\/acsabm.6c01554","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:06:38Z","timestamp":1791403598000},"source":"Crossref","is-referenced-by-count":0,"title":["Aloe-Emodin Interaction Study with Human Telomeric G-Quadruplex DNA under K+ and Na+ Conditions"],"prefix":"10.1021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6426-2400","authenticated-orcid":true,"given":"Priya","family":"Kumari","sequence":"first","affiliation":[{"name":"Dayalbagh Educational Institute , , Dayalbagh, ,","place":["Agra, India, 282005"]},{"name":"Indian Institute of Technology , , ,","place":["Kanpur, India, 208016"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5410-9904","authenticated-orcid":true,"given":"Manish S.","family":"Sengar","sequence":"additional","affiliation":[{"name":"Danube Private University , , ,","place":["Krems, Austria, 3500"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4513-1739","authenticated-orcid":true,"given":"Kumud","family":"Pandav","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Bioengineering, Indian Institute of Technology Roorkee , , ,","place":["Uttarakhand, Roorkee, India, 247667"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritu","family":"Barthwal","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Bioengineering, Indian Institute of Technology Roorkee , , ,","place":["Uttarakhand, Roorkee, India, 247667"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8829-3028","authenticated-orcid":true,"given":"Surat","family":"Kumar","sequence":"additional","affiliation":[{"name":"Dayalbagh Educational Institute , , Dayalbagh, ,","place":["Agra, India, 282005"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7130-7734","authenticated-orcid":true,"given":"Arvind K. Singh","family":"Chandel","sequence":"additional","affiliation":[{"name":"Bernal Institute, University of Limerick , ,","place":["Limerick, Ireland, V94 T9PX"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"2026100716063298200_cit1","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1038\/nrd3428","article-title":"Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?","volume":"10","author":"Balasubramanian","year":"2011","journal-title":"Nat. Rev. Drug Discov."},{"key":"2026100716063298200_cit2","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1038\/bjc.1997.90","article-title":"Telomerase activity in normal and malignant mammalian tissues: feasibility of telomerase as a target for cancer chemotherapy","volume":"75","author":"Burger","year":"1997","journal-title":"Br. J. Cancer"},{"key":"2026100716063298200_cit3","doi-asserted-by":"publisher","first-page":"12367","DOI":"10.1021\/bi981330n","article-title":"NMR-based model of a telomerase-inhibiting compound bound to G-quadruplex DNA","volume":"37","author":"Fedoroff","year":"1998","journal-title":"Biochem."},{"key":"2026100716063298200_cit4","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.tcb.2009.05.00","article-title":"G-quadruplex structures: in vivo evidence and function","volume":"19","author":"Lipps","year":"2009","journal-title":"Trends Cell Biol."},{"key":"2026100716063298200_cit5","doi-asserted-by":"publisher","first-page":"6422","DOI":"10.1039\/c4cc00611a","article-title":"Advances in the molecular design of potential anticancer agents via targeting of human telomeric DNA","volume":"50","author":"Maji","year":"2014","journal-title":"Chem. Commun."},{"key":"2026100716063298200_cit6","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.ymeth.2012.03.011","article-title":"Circular dichroism and guanine quadruplexes","volume":"57","author":"Vorl\u00ed\u010dkov\u00e1","year":"2012","journal-title":"Methods"},{"key":"2026100716063298200_cit7","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.ijbiomac.2022.08.156","article-title":"Molecular recognition of telomere DNA sequence by 2, 6 anthraquinone derivatives leads to thermal stabilization and induces apoptosis in cancer cells","volume":"221","author":"Dey","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"2026100716063298200_cit8","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1002\/chem.201904923","article-title":"Intercalation of a heterocyclic ligand between quartets in a G-rich tetrahelical structure","volume":"26","author":"Kotar","year":"2020","journal-title":"Chem. Eur. J."},{"key":"2026100716063298200_cit9","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1016\/j.ijbiomac.2018.09.154","article-title":"Binding of anticancer drug daunomycin to parallel G-quadruplex DNA [d-(TTGGGGT)]4 leads to thermal stabilization: A multispectroscopic investigation","volume":"120","author":"Tariq","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"2026100716063298200_cit10","doi-asserted-by":"publisher","first-page":"11054","DOI":"10.1002\/ange.201804667","article-title":"Molecular recognition of the hybrid-2 human telomeric G-quadruplex by epiberberine: insights into conversion of telomeric G-quadruplex structures","volume":"130","author":"Lin","year":"2018","journal-title":"Angew. Chem."},{"key":"2026100716063298200_cit11","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.molstruc.2016.08.007","article-title":"Interaction of anthraquinone anti-cancer drugs with DNA: Experimental and computational quantum chemical study","volume":"1127","author":"Al-Otaibi","year":"2017","journal-title":"J. Mol. Str."},{"key":"2026100716063298200_cit12","article-title":"Aloe vera: Nature's silent healer","volume-title":"AlasdairAloeVera","author":"Barcroft","year":"2003"},{"key":"2026100716063298200_cit13","doi-asserted-by":"publisher","DOI":"10.1002\/jmr.2786","article-title":"Interaction of aloe active compounds with calf thymus DNA","volume":"32","author":"Das","year":"2019","journal-title":"J. Mol. Rec."},{"key":"2026100716063298200_cit14","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1016\/S0024-3205(02)01900-8","article-title":"The antiproliferative activity of aloe-emodin is through p53-dependent and p21-dependent apoptotic pathway in human hepatoma cell lines","volume":"71","author":"Kuo","year":"2002","journal-title":"Life Sci."},{"key":"2026100716063298200_cit15","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.17576\/jsm-2015-4408-09","article-title":"Aloe emodin induces apoptosis in ER+-breast cancer cells; MCF-7 through IGF-1R signalling pathway","volume":"44","author":"Amin","year":"2015","journal-title":"Sains Malays"},{"key":"2026100716063298200_cit16","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1002\/ijc.20676","article-title":"Release of nucleophosmin from the nucleus: Involvement in aloe-emodin-induced human lung non-small carcinoma cell apoptosis","volume":"113","author":"Lee","year":"2005","journal-title":"Int. J. Cancer"},{"key":"2026100716063298200_cit17","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1142\/S0192415X17500215","article-title":"Aloe-emodin enhances tamoxifen cytotoxicity by suppressing Ras\/ERK and PI3K\/mTOR in breast cancer cells","volume":"45","author":"Tseng","year":"2017","journal-title":"Am. J. Chin. Med."},{"key":"2026100716063298200_cit18","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1111\/j.1745-7254.2007.00707.x","article-title":"Anticancer effect of aloe-emodin on cervical cancer cells involves G2\/M arrest and induction of differentiation","volume":"28","author":"Guo","year":"2007","journal-title":"Acta Pharmacol. Sin."},{"key":"2026100716063298200_cit19","doi-asserted-by":"publisher","DOI":"10.3390\/cells13141186","article-title":"Advancements in utilizing natural compounds for modulating autophagy in liver cancer: Molecular mechanisms and therapeutic targets","volume":"13","author":"Rahman","year":"2024","journal-title":"Cells"},{"key":"2026100716063298200_cit20","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28166024","article-title":"Aloe-emodin overcomes anti-cancer drug resistance to temozolomide and prevents colony formation and migration in primary human glioblastoma cell lines NULU and ZAR","volume":"28","author":"Staffieri","year":"2023","journal-title":"Molecules"},{"key":"2026100716063298200_cit21","doi-asserted-by":"publisher","first-page":"3887","DOI":"10.7314\/apjcp.2015.16.9.3887","article-title":"Effects of aloe-emodin and emodin on proliferation of the MKN45 human gastric cancer cell line","volume":"16","author":"Chihara","year":"2015","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"2026100716063298200_cit22","doi-asserted-by":"publisher","first-page":"160","DOI":"10.46309\/biodicon.2020.753046","article-title":"The antiproliferative potential of isolated emodin and aloe-emodin from Rheum ribes on different cancer cell lines","volume":"13","author":"Erdo\u011fan","year":"2020","journal-title":"Biol. Diversity Conserv."},{"key":"2026100716063298200_cit23","first-page":"283","article-title":"Anti-cancer effects of aloe-emodin: a systematic review","volume":"3","author":"Sanders","year":"2017","journal-title":"J. Clin. Transl. Res."},{"key":"2026100716063298200_cit24","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S1543-1150(03)00005-X","article-title":"A review on the relationship between Aloe vera components and their biologic effects","volume":"1","author":"Choi","year":"2003","journal-title":"Semin. Integr. Med."},{"key":"2026100716063298200_cit25","first-page":"81","article-title":"Biophysical, Anticancer, Antibacterial and Antiviral Profiles of Aloe-emodin: A Mini-Review","volume":"11","author":"Kumari","year":"2021","journal-title":"Chem. Biol. Interface"},{"key":"2026100716063298200_cit26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/376123","article-title":"Emodin and aloe-emodin suppress breast cancer cell proliferation through ER\u03b1 inhibition","volume":"2013","author":"Huang","year":"2013","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"2026100716063298200_cit27","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/7928200","article-title":"Advances in understanding the role of aloe emodin and targeted drug delivery systems in cancer","volume":"2022","author":"\u015eeker Karatoprak","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"2026100716063298200_cit28","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1007\/s43440-020-00062-w","article-title":"Aloe emodin inhibits telomerase activity in breast cancer cells: transcriptional and enzymological mechanism","volume":"72","author":"Wang","year":"2020","journal-title":"Pharmacol. Rep."},{"key":"2026100716063298200_cit29","first-page":"1123","article-title":"Spectroscopic studies on the interaction of aloe-emodin and DNA","volume":"23","author":"Qi-Qian","year":"2011","journal-title":"Asian J. Chem."},{"key":"2026100716063298200_cit30","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1562\/0031-8655(2002)0750346PAPOAE2.0.CO2","article-title":"Photochemistry and Phototoxicity of Aloe Emodin","volume":"75","author":"Vath","year":"2002","journal-title":"Photochem. Photobiol."},{"key":"2026100716063298200_cit31","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.toxrep.2017.12.024","article-title":"Interaction of anthraquinones of Cassia occidentalis seeds with DNA and Glutathione","volume":"5","author":"Panigrahi","year":"2018","journal-title":"Toxicol. Rep."},{"key":"2026100716063298200_cit32","doi-asserted-by":"publisher","first-page":"18344","DOI":"10.1021\/acsomega.1c02207","article-title":"Binding studies of aloe-active compounds with G-quadruplex sequences","volume":"6","author":"Das","year":"2021","journal-title":"ACS Omega"},{"key":"2026100716063298200_cit33","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232416018","article-title":"Investigation of the interaction between Aloe vera anthraquinone metabolites and c-myc and C-kit G-quadruplex DNA structures","volume":"23","author":"Dallavalle","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"2026100716063298200_cit34","doi-asserted-by":"publisher","first-page":"9686","DOI":"10.1080\/07391102.2022.2145370","article-title":"Targeting aloe active compounds to c-KIT promoter G-quadruplex and comparative study of their anti-proliferative property","volume":"41","author":"Das","year":"2023","journal-title":"J. Biomol. Str. Dyn."},{"key":"2026100716063298200_cit35","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s13404-011-0022-9","article-title":"Gold nanorod-based FRET assay for selection of G-quadruplex-binding ligands","volume":"44","author":"Jin","year":"2011","journal-title":"Gold Bull."},{"key":"2026100716063298200_cit36","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1039\/c2an16051j","article-title":"Identifying G-quadruplex-binding ligands using DNA-functionalized gold nanoparticles","volume":"137","author":"Qiao","year":"2012","journal-title":"Analyst"},{"key":"2026100716063298200_cit37","doi-asserted-by":"publisher","first-page":"16256","DOI":"10.1039\/c5ra25612g","article-title":"High-throughout identification of telomere-binding ligands based on photo-induced electron transfer","volume":"6","author":"Shi","year":"2016","journal-title":"RSC Adv."},{"key":"2026100716063298200_cit38","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1016\/j.bios.2016.09.055","article-title":"High-throughput identification of telomere-binding ligands based on the fluorescence regulation of DNA-copper nanoparticles","volume":"87","author":"Yang","year":"2017","journal-title":"Biosens. Bioelectron."},{"key":"2026100716063298200_cit39","doi-asserted-by":"publisher","first-page":"2440","DOI":"10.1093\/nar\/gkm009","article-title":"Structure of the intramolecular human telomeric G-quadruplex in potassium solution: a novel adenine triple formation","volume":"35","author":"Dai","year":"2007","journal-title":"Nucl. Acids Res."},{"key":"2026100716063298200_cit40","doi-asserted-by":"publisher","first-page":"4927","DOI":"10.1093\/nar\/gkm522","article-title":"Structure of the Hybrid-2 type intramolecular human telomeric G-quadruplex in K+ solution: insights into structure polymorphism of the human telomeric sequence","volume":"35","author":"Dai","year":"2007","journal-title":"Nucl. Acids Res."},{"key":"2026100716063298200_cit41","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/0969-2126(93)90015-9","article-title":"Solution structure of the human telomeric repeat d [AG3(T2AG3)3] G-tetraplex","volume":"1","author":"Wang","year":"1993","journal-title":"Structure"},{"key":"2026100716063298200_cit42","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.jphotobiol.2016.06.019","article-title":"A 4:1 stoichiometric binding and stabilization of mitoxantrone-parallel stranded G-quadruplex complex established by spectroscopy techniques","volume":"162","author":"Pradeep","year":"2016","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"2026100716063298200_cit43","first-page":"112","article-title":"Spectroscopic and Molecular Docking Studies on the Interaction of Aloe-emodin with GC and AT specific DNA Oligonucleotides","volume":"11","author":"Yadav","year":"2021","journal-title":"Chem. Biol. Interface"},{"key":"2026100716063298200_cit44","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.bpc.2016.09.006","article-title":"Binding of the alkaloid coralyne to parallel G-quadruplex DNA [d-(TTGGGGT)]4 studied by multi-spectroscopic techniques","volume":"219","author":"Padmapriya","year":"2016","journal-title":"Biophys. Chem."},{"key":"2026100716063298200_cit45","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1002\/cbic.201500588","article-title":"Molecular recognition of parallel DNA quadruplex d (TTAGGGT)4 by mitoxantrone: binding with 1:2 stoichiometry leading to thermal stabilization and telomerase inhibition","volume":"17","author":"Tripathi","year":"2016","journal-title":"ChemBioChem"},{"key":"2026100716063298200_cit46","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1016\/j.ijbiomac.2019.08.109","article-title":"Molecular recognition of 3+1 hybrid human telomeric G-quadruplex DNA d-[AGGG(TTAGGG)3] by anticancer drugs epirubicin and adriamycin leads to thermal stabilization","volume":"139","author":"Raje","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"2026100716063298200_cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.rechem.2023.101148","article-title":"Spectroscopy evidence of interaction of 1, 5 disubstituted piperidino-amido anthraquinone derivative with human telomeric G-quadruplex DNA: basis of anticancer action","volume":"6","author":"Kumari","year":"2023","journal-title":"Results Chem."},{"key":"2026100716063298200_cit48","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/978-3-319-21756-7_7","volume-title":"The alkali metal ions: Their role for life","author":"Largy","year":"2016"},{"key":"2026100716063298200_cit49","doi-asserted-by":"publisher","first-page":"3594","DOI":"10.1021\/jp045274d","article-title":"Effect of ions on the polymorphism, effective charge, and stability of human telomeric DNA Photon correlation spectroscopy and circular dichroism studies","volume":"109","author":"W\u0142odarczyk","year":"2005","journal-title":"J. Phys. Chem. B"},{"key":"2026100716063298200_cit50","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.theochem.2005.11.005","article-title":"Theoretical study on photophysical and photosensitive properties of aloe emodin","volume":"758","author":"Shen","year":"2006","journal-title":"J. Mol. Str."},{"key":"2026100716063298200_cit51","doi-asserted-by":"publisher","first-page":"3051","DOI":"10.1021\/ja00190a046","article-title":"Mixed-ligand complexes of ruthenium (II): factors governing binding to DNA","volume":"111","author":"Pyle","year":"1989","journal-title":"J. Am. Chem. Soc."},{"key":"2026100716063298200_cit52","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1039\/c0cp00898b","article-title":"Affinity of the anthracycline antitumor drugs Doxorubicin and Sabarubicin for human telomeric G-quadruplex structures","volume":"13","author":"Manet","year":"2010","journal-title":"Phys. Chem. Chem. Phys."},{"key":"2026100716063298200_cit53","doi-asserted-by":"publisher","first-page":"4161","DOI":"10.1021\/bi00745a020","article-title":"Quenching of fluorescence by oxygen. Probe for structural fluctuations in macromolecules","volume":"12","author":"Lakowicz","year":"1973","journal-title":"Biochemistry"},{"key":"2026100716063298200_cit54","doi-asserted-by":"publisher","first-page":"4654","DOI":"10.1021\/bi602511p","article-title":"Biophysical characterization of the human telomeric (TTAGGG)4 repeat in a potassium solution","volume":"46","author":"Antonacci","year":"2007","journal-title":"Biochemistry"},{"key":"2026100716063298200_cit55","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.ymeth.2007.02.009","article-title":"Circular dichroism of quadruplex DNAs: applications to structure, cation effects and ligand binding","volume":"43","author":"Paramasivan","year":"2007","journal-title":"Methods"},{"key":"2026100716063298200_cit56","doi-asserted-by":"publisher","first-page":"3744","DOI":"10.1039\/c4ob00220b","article-title":"Aryl ethynyl anthraquinones: a useful platform for targeting telomeric G-quadruplex structures","volume":"12","author":"Percivalle","year":"2014","journal-title":"Org. Biomol. Chem."},{"key":"2026100716063298200_cit57","doi-asserted-by":"publisher","first-page":"15950","DOI":"10.1021\/ja8046552","article-title":"Diarylethynyl amides that recognize the parallel conformation of genomic promoter DNA G-quadruplexes","volume":"130","author":"Dash","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"2026100716063298200_cit58","doi-asserted-by":"publisher","first-page":"5796","DOI":"10.1039\/c3cc42721h","article-title":"Dual recognition of the human telomeric G-quadruplex by a neomycin\u2013anthraquinone conjugate","volume":"49","author":"Ranjan","year":"2013","journal-title":"Chem. Commun."},{"key":"2026100716063298200_cit59","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.bpc.2006.06.006","article-title":"Structure-specific recognition of quadruplex DNA by organic cations: influence of shape, substituents and charge","volume":"126","author":"White","year":"2007","journal-title":"Biophys. Chem."},{"key":"2026100716063298200_cit60","doi-asserted-by":"publisher","first-page":"2453","DOI":"10.1039\/c4ob02097a","article-title":"Binding modes of a core-extended metalloporphyrin to human telomeric DNA G-quadruplexes","volume":"13","author":"Rubio-Magnieto","year":"2015","journal-title":"Org. Biomol. Chem."},{"key":"2026100716063298200_cit61","doi-asserted-by":"publisher","first-page":"81","DOI":"10.3390\/molecules23010081","article-title":"Design, synthesis and biological evaluation of new substituted diquinolinyl-pyridine ligands as anticancer agents by targeting G-Quadruplex","volume":"23","author":"Das","year":"2017","journal-title":"Molecules"},{"key":"2026100716063298200_cit62","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1021\/ja5099403","article-title":"Ligand-Induced Conformational Changes with Cation Ejection upon Binding to Human Telomeric DNA G-Quadruplexes","volume":"137","author":"Marchand","year":"2015","journal-title":"J. Am. Chem. Soc."},{"issue":"3","key":"2026100716063298200_cit63","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1016\/j.bbagen.2017.10.020","article-title":"Kinetic evidence for interaction of TMPyP4 with two different G-quadruplex conformations of human telomeric DNA","volume":"1862","author":"P\u00e9rez-Arnaiz","year":"2018","journal-title":"Biochim. Biophys. Acta, Gen. Subj."},{"key":"2026100716063298200_cit64","doi-asserted-by":"publisher","first-page":"14925","DOI":"10.18632\/oncotarget.7483","article-title":"Telomere targeting with a novel G-quadruplex-interactive ligand BRACO-19 induces T-loop disassembly and telomerase displacement in human glioblastoma cells","volume":"7","author":"Zhou","year":"2016","journal-title":"Oncotarget"},{"key":"2026100716063298200_cit65","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1007\/BF00273419","article-title":"In-vitro antitumor activity of mitomycin C derivative (RM-49) and new anticancer antibiotics (FK973) against lung cancer cell lines determined by tetrazolium dye (MTT) assay","volume":"22","author":"Horiuchi","year":"1988","journal-title":"Cancer Chemother. Pharmacol."},{"issue":"2","key":"2026100716063298200_cit66","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.toxlet.2005.07.001","article-title":"In-vitro cytotoxicity assays: comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride","volume":"160","author":"Fotakis","year":"2006","journal-title":"Toxicol. Lett."}],"container-title":["ACS Applied Bio Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsabm.6c01554","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/aabmcb\/article-pdf\/doi\/10.1021\/acsabm.6c01554\/68752788\/mt-2026-01554j.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/aabmcb\/article-pdf\/doi\/10.1021\/acsabm.6c01554\/68752788\/mt-2026-01554j.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:49:15Z","timestamp":1791409755000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/aabmcb\/article\/doi\/10.1021\/acsabm.6c01554\/5444979\/Aloe-Emodin-Interaction-Study-with-Human-Telomeric"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,6]]},"references-count":66,"URL":"https:\/\/doi.org\/10.1021\/acsabm.6c01554","relation":{},"ISSN":["2576-6422"],"issn-type":[{"value":"2576-6422","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,6]]}}}