{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T08:45:45Z","timestamp":1792140345939,"version":"4.4.0"},"reference-count":31,"publisher":"American Chemical Society (ACS)","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100004386","name":"Universiti Malaya","doi-asserted-by":"publisher","award":["UMREG022-2025"],"award-info":[{"award-number":["UMREG022-2025"]}],"id":[{"id":"10.13039\/501100004386","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004386","name":"Universiti Malaya","doi-asserted-by":"publisher","award":["UMTRG0182025"],"award-info":[{"award-number":["UMTRG0182025"]}],"id":[{"id":"10.13039\/501100004386","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Effective wound-fluid management is essential in medical applications, as dressings must absorb, retain, and regulate excess blood, exudate, and other biological fluids. Gelatin\u2013hyaluronic acid (Gel\/HA) hydrogels are promising dressing materials because they provide a hydrated, tissue-mimetic environment and combine the biological functions of both polymers. Their performance depends strongly on the crosslinking strategy, which regulates network architecture, fluid transport, and mechanical integrity. Three Gel\/HA networks were prepared by physical association (Network I), glutaraldehyde-mediated covalent crosslinking (Network II), and PEGDA-mediated interpenetrating-network formation (Network III). Molecular interactions, morphology, fluid uptake, and mechanical properties were evaluated within a structure\u2013transport\u2013function framework. The networks exhibited distinct pore structures, with average pore sizes of 21 \u00b1 7, 2.3 \u00b1 0.8, and 9 \u00b1 3 \u03bcm and porosities of 74 \u00b1 3, 59 \u00b1 3, and 67 \u00b1 3% for Networks I\u2013III, respectively. Tensile strength increased from 62 \u00b1 5 kPa for Network I to 127 \u00b1 7 kPa for Network II and 215 \u00b1 9 kPa for Network III, while elongation at break increased from 152 \u00b1 9 to 257 \u00b1 12 and 343 \u00b1 14%, respectively. Simulated blood uptake at 240 min reached 483 \u00b1 45, 842 \u00b1 59, and 1285 \u00b1 72% for Networks I\u2013III, respectively. An integrated hydrogel performance index was used as a comparative dimensionless descriptor of selected transport and mechanical properties. Overall, the results show that network formulation yields distinct combinations of pore architecture, fluid transport, and mechanical performance, providing a basis for comparing Gel\/HA hydrogel designs for wound management applications that balance fluid management and mechanical properties.<\/jats:p>","DOI":"10.1021\/acsabm.6c01693","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:01:59Z","timestamp":1792123319000},"source":"Crossref","is-referenced-by-count":0,"title":["Crosslinking-Dependent Structure\u2013Transport\u2013Function Relationships in Gelatin\u2013Hyaluronic Acid Hydrogels for Wound-Fluid Management"],"prefix":"10.1021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4368-6922","authenticated-orcid":true,"given":"Nurdiana","family":"Nordin","sequence":"first","affiliation":[{"name":"Universiti Malaya , , ,","place":["Kuala Lumpur, Malaysia, 50603"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Arman","family":"Shaharulnizam","sequence":"additional","affiliation":[{"name":"Universiti Malaya , , ,","place":["Kuala Lumpur, Malaysia, 50603"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlin Alya","family":"Zamlis","sequence":"additional","affiliation":[{"name":"Universiti Malaya , , ,","place":["Kuala Lumpur, Malaysia, 50603"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4293-9142","authenticated-orcid":true,"given":"Nurfarhanim Abu","family":"Bakar","sequence":"additional","affiliation":[{"name":"Taylor\u2019s University , , Taylor\u2019s Lakeside Campus, No. 1 Jalan Taylor , , ,","place":["Subang Jaya, Selangor, Malaysia, 47500"]},{"name":"Taylor\u2019s University , , Taylor\u2019s Lakeside Campus, No. 1 Jalan Taylor , , ,","place":["Subang Jaya, Selangor, Malaysia, 47500"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"issue":"11","key":"2026101600014996800_cit1","doi-asserted-by":"publisher","first-page":"4559","DOI":"10.1007\/S10924-023-02906-X","article-title":"Silk-Based Biopolymers Promise Extensive Biomedical Applications in Tissue Engineering, Drug Delivery, and BioMEMS","volume":"31","author":"Farahani","year":"2023","journal-title":"J. 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