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These gels rely on noncovalent interactions, including hydrogen bonding and \u03c0\u2013\u03c0 stacking, enabling tunable mechanical, optical, and rheological properties. This review explores the self-assembly mechanisms of organic supramolecular gels and their applications in drug delivery, tissue engineering, environmental remediation, and sensing technologies. The relationship between molecular structure and gel performance is critically examined along with recent advancements in enhancing stability and responsiveness. While these materials offer exciting potential, challenges such as mechanical fragility, limited long-term stability, and scalability require further research. Future efforts should focus on designing supramolecular gels with enhanced robustness, biocompatibility, and adaptability to external stimuli. Addressing these limitations will pave the way for next-generation smart materials in biomedical, environmental, and industrial applications.<\/jats:p>","DOI":"10.1021\/acsabm.6c01854","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:02:49Z","timestamp":1790830969000},"page":"9440-9470","source":"Crossref","is-referenced-by-count":0,"title":["Recent Advances in Organic Supramolecular Gels: Self-Assembly and Functional Applications"],"prefix":"10.1021","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5443-8070","authenticated-orcid":true,"given":"Mani","family":"Rajasekar","sequence":"first","affiliation":[{"name":"Sathyabama Institute of Science and Technology , (Deemed to be University), , ,","place":["Chennai, Tamil Nadu, India, 600 119"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"2026101904074750500_cit1","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1021\/acspolymersau.5c00053","article-title":"Smart Polymer-Derived Injectable Hydrogels: Current Status and Future Perspectives","volume":"5","author":"Maity","year":"2025","journal-title":"ACS Polym. 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