{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T15:19:48Z","timestamp":1792336788980,"version":"4.4.0"},"reference-count":76,"publisher":"American Chemical Society (ACS)","issue":"25","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"vor","delay-in-days":19,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_ccby_termsofuse.html"}],"funder":[{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/N021150\/1"],"award-info":[{"award-number":["BB\/N021150\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Neisseria gonorrhoeae is among the most multidrug-resistant bacteria in circulation today, and new treatments are urgently needed. In this work, we demonstrate the ability of 5-mercapto-2-nitrobenzoic acid-coated silver nanoclusters (MNBA-AgNCs) to kill strains of Neisseria gonorrhoeae. Using an in vitro bactericidal assay, MNBA-AgNCs had been found to show significantly higher anti-gonococcal bioactivity than the antibiotics ceftriaxone and azithromycin and silver nitrate. These nanoclusters were effective against both planktonic bacteria and a gonococcal infection of human cell cultures in vitro. Treatment of human cells in vitro with MNBA-AgNCs did not induce significant release of lactate dehydrogenase, suggesting minimal cytotoxicity to eukaryotic cells. Our results suggest that MNBA-AgNCs hold great potential for topical treatment of localized gonorrhoeae.<\/jats:p>","DOI":"10.1021\/acsami.0c06163","type":"journal-article","created":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T15:54:32Z","timestamp":1591977272000},"page":"27994-28003","source":"Crossref","is-referenced-by-count":29,"title":["Bactericidal\nEffect of 5-Mercapto-2-nitrobenzoic\nAcid-Coated Silver Nanoclusters against Multidrug-Resistant\n                    <i>Neisseria gonorrhoeae<\/i>"],"prefix":"10.1021","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7404-352X","authenticated-orcid":true,"given":"Mari\u0301a Isabel","family":"Luci\u0301o","sequence":"first","affiliation":[{"name":"University of Southampton , , ,","place":["Southampton, U.K., SO17 1BJ"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Eleni","family":"Kyriazi","sequence":"additional","affiliation":[{"name":"University of Southampton , , ,","place":["Southampton, U.K., SO17 1BJ"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Hamilton","sequence":"additional","affiliation":[{"name":"University of Southampton , , ,","place":["Southampton, U.K., SO16 6YD"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Batista","sequence":"additional","affiliation":[{"name":"University of Southampton , , ,","place":["Southampton, U.K., SO16 6YD"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Sheppard","sequence":"additional","affiliation":[{"name":"University of Southampton , , ,","place":["Southampton, U.K., SO16 6YD"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Sams-Dodd","sequence":"additional","affiliation":[{"name":"University of Southampton , , ,","place":["Southampton, U.K., SO16 6YD"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Victoria","family":"Humbert","sequence":"additional","affiliation":[{"name":"University of Southampton , , ,","place":["Southampton, U.K., SO16 6YD"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5498-1236","authenticated-orcid":true,"given":"Irshad","family":"Hussain","sequence":"additional","affiliation":[{"name":"Lahore University of Management Sciences (LUMS) , , DHA, ,","place":["Lahore Cantt, Pakistan, 54792"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myron","family":"Christodoulides","sequence":"additional","affiliation":[{"name":"University of Southampton , , ,","place":["Southampton, U.K., SO16 6YD"]},{"name":"University of Southampton , , ,","place":["Southampton, U.K., SO17 1BJ"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9847-6706","authenticated-orcid":true,"given":"Antonios G.","family":"Kanaras","sequence":"additional","affiliation":[{"name":"University of Southampton , , ,","place":["Southampton, U.K., SO17 1BJ"]},{"name":"University of Southampton , , ,","place":["Southampton, U.K., SO17 1BJ"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,6,12]]},"reference":[{"key":"2026090315530932200_cit1","doi-asserted-by":"publisher","first-page":"548","DOI":"10.2471\/BLT.18.228486","article-title":"Chlamydia, Gonorrhoea,\nTrichomoniasis and Syphilis:\nGlobal Prevalence and Incidence Estimates, 2016","volume":"97","author":"Rowley","year":"2019","journal-title":"Bull. 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