{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T02:46:53Z","timestamp":1789008413416,"version":"build-2803163510"},"reference-count":37,"publisher":"American Chemical Society (ACS)","issue":"39","license":[{"start":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T00:00:00Z","timestamp":1600214400000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_ccby_termsofuse.html"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["RTG 2046"],"award-info":[{"award-number":["RTG 2046"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004189","name":"Max-Planck-Gesellschaft","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/501100004189","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Malaria, a mosquito-borne disease caused by Plasmodium species, claims more than 400,000 lives globally each year. The increasing drug resistance of the parasite renders the development of new anti-malaria drugs necessary. Alternatively, better delivery systems for already marketed drugs could help to solve the resistance problem. Herein, we report glucose-based ultra-small gold nanoparticles (Glc-NCs) that bind to cysteine-rich domains of Plasmodium falciparum surface proteins. Microscopy shows that Glc-NCs bind specifically to extracellular and all intra-erythrocytic stages of P. falciparum. Glc-NCs may be used as drug delivery agents as illustrated for ciprofloxacin, a poorly soluble antibiotic with low antimalarial activity. Ciprofloxacin conjugated to Glc-NCs is more water-soluble than the free drug and is more potent. Glyco-gold nanoparticles that target cysteine-rich domains on parasites may be helpful for the prevention and treatment of malaria.<\/jats:p>","DOI":"10.1021\/acsami.0c09075","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T06:48:32Z","timestamp":1599029312000},"page":"43380-43387","source":"Crossref","is-referenced-by-count":56,"title":["Targeting\nand Inhibiting\n                    <i>Plasmodium falciparum<\/i>\n                    Using Ultra-small Gold Nanoparticles"],"prefix":"10.1021","volume":"12","author":[{"given":"Silvia","family":"Varela-Aramburu","sequence":"first","affiliation":[{"name":"Max Planck Institute of Colloids and Interfaces , , Am Mu\u0308hlenberg 1 , ,","place":["Potsdam, Germany, 14476"]},{"name":"Freie Universita\u0308t Berlin , , Arnimallee 22 , ,","place":["Berlin, Germany, 14195"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandradhish","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Colloids and Interfaces , , Am Mu\u0308hlenberg 1 , ,","place":["Potsdam, Germany, 14476"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Goerdeler","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Colloids and Interfaces , , Am Mu\u0308hlenberg 1 , ,","place":["Potsdam, Germany, 14476"]},{"name":"Freie Universita\u0308t Berlin , , Arnimallee 22 , ,","place":["Berlin, Germany, 14195"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Priegue","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Colloids and Interfaces , , Am Mu\u0308hlenberg 1 , ,","place":["Potsdam, Germany, 14476"]},{"name":"Freie Universita\u0308t Berlin , , Arnimallee 22 , ,","place":["Berlin, Germany, 14195"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oren","family":"Moscovitz","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Colloids and Interfaces , , Am Mu\u0308hlenberg 1 , ,","place":["Potsdam, Germany, 14476"]},{"name":"Freie Universita\u0308t Berlin , , Arnimallee 22 , ,","place":["Berlin, Germany, 14195"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3394-8466","authenticated-orcid":true,"given":"Peter H.","family":"Seeberger","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Colloids and Interfaces , , Am Mu\u0308hlenberg 1 , ,","place":["Potsdam, Germany, 14476"]},{"name":"Freie Universita\u0308t Berlin , , Arnimallee 22 , ,","place":["Berlin, Germany, 14195"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,9,2]]},"reference":[{"key":"2026090212175692100_cit1","unstructured":"World Health Organization.\n          .  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Drug\nDelivery Rev."},{"key":"2026090212175692100_cit5","doi-asserted-by":"publisher","first-page":"2527","DOI":"10.3390\/molecules23102527","article-title":"Polymeric\nNanocarriers for the Delivery of Antimalarials","volume":"23","author":"Mhlwatika","year":"2018","journal-title":"Molecules"},{"key":"2026090212175692100_cit6","doi-asserted-by":"publisher","first-page":"40169","DOI":"10.1074\/jbc.M509631200","article-title":"Distinct Protein Classes Including Novel Merozoite\nSurface Antigens in Raft-like Membranes of Plasmodium Falciparum","volume":"280","author":"Sanders","year":"2005","journal-title":"J. Biol. 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Biochem."},{"key":"2026090212175692100_cit21","doi-asserted-by":"publisher","first-page":"6516","DOI":"10.1021\/ja051145e","article-title":"Selective Detection\nof Cysteine and Glutathione Using Gold Nanorods","volume":"127","author":"Sudeep","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"2026090212175692100_cit22","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.3762\/bjnano.7.118","article-title":"Straightforward and Robust Synthesis\nof Monodisperse Surface-Functionalized Gold Nanoclusters","volume":"7","author":"Varela-Aramburu","year":"2016","journal-title":"Beilstein J. 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Agents Chemother."},{"key":"2026090212175692100_cit28","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1016\/S0140-6736(88)92056-9","article-title":"CIPROFLOXACIN\nAND MALARIA","volume":"331","author":"Krishna","year":"1988","journal-title":"Lancet"},{"key":"2026090212175692100_cit29","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1128\/aac.32.8.1182","article-title":"Activity\nof Fluoroquinolone Antibiotics against Plasmodium Falciparum in Vitro","volume":"32","author":"Divo","year":"1988","journal-title":"Antimicrob. Agents Chemother."},{"key":"2026090212175692100_cit30","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.molbiopara.2007.01.005","article-title":"The Effects of Anti-Bacterials on the Malaria Parasite\nPlasmodium Falciparum","volume":"152","author":"Goodman","year":"2007","journal-title":"Mol. Biochem. Parasitol."},{"key":"2026090212175692100_cit31","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.ijantimicag.2006.06.003","article-title":"Evaluation of Antimalarial\nand Fluoroquinolone Combinations against Plasmodium Falciparum in\nVitro","volume":"28","author":"Soares","year":"2006","journal-title":"Int. J. Antimicrob. Agents"},{"key":"2026090212175692100_cit32","doi-asserted-by":"publisher","first-page":"577","DOI":"10.3109\/14756360903373350","article-title":"Ciprofloxacin: Review on Developments\nin Synthetic, Analytical, and Medicinal Aspects","volume":"25","author":"Sharma","year":"2010","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"2026090212175692100_cit33","doi-asserted-by":"publisher","first-page":"1732","DOI":"10.1093\/ajhp\/53.14.1732","article-title":"Zwitterions and PH\u2013Dependent\nSolubility","volume":"53","author":"Williams","year":"1996","journal-title":"Am. J. Heal. Pharm."},{"key":"2026090212175692100_cit34","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1186\/s12936-015-1011-x","article-title":"An Improved SYBR Green-1-Based Fluorescence Method\nfor the Routine Monitoring of Plasmodium Falciparum Resistance to\nAnti-Malarial Drugs","volume":"14","author":"Dery","year":"2015","journal-title":"Malar. J."},{"key":"2026090212175692100_cit35","doi-asserted-by":"publisher","first-page":"104902","DOI":"10.1063\/1.5013056","article-title":"The Effect of Molecular Shape on\nOligomerization of Hydrophobic Drugs: Molecular Simulations of Ciprofloxacin\nand Nutlin","volume":"148","author":"Li","year":"2018","journal-title":"J. Chem. Phys."},{"key":"2026090212175692100_cit36","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1039\/df9511100055","article-title":"A Study of the Nucleation and Growth Processes in the\nSynthesis of Colloidal Gold","volume":"11","author":"Turkevich","year":"1951","journal-title":"Discuss. Faraday\nSoc."},{"key":"2026090212175692100_cit37","doi-asserted-by":"publisher","first-page":"1899","DOI":"10.1038\/nprot.2009.198","article-title":"Synchronous Culture\nof Plasmodium Falciparum at High Parasitemia Levels","volume":"4","author":"Radfar","year":"2009","journal-title":"Nat. Protoc."}],"container-title":["ACS Applied Materials &amp; Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.0c09075","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/aamick\/article-pdf\/12\/39\/43380\/66929680\/acsami.0c09075.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/aamick\/article-pdf\/12\/39\/43380\/66929680\/acsami.0c09075.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T16:18:04Z","timestamp":1788365884000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/aamick\/article\/12\/39\/43380\/587215\/Targeting-and-Inhibiting-Plasmodium-falciparum"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,2]]},"references-count":37,"journal-issue":{"issue":"39","published-online":{"date-parts":[[2020,9,2]]},"published-print":{"date-parts":[[2020,9,30]]}},"URL":"https:\/\/doi.org\/10.1021\/acsami.0c09075","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,2]]}}}