{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T04:30:06Z","timestamp":1792816206691,"version":"4.5.0"},"reference-count":36,"publisher":"American Chemical Society (ACS)","issue":"41","license":[{"start":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T00:00:00Z","timestamp":1600300800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T00:00:00Z","timestamp":1600300800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T00:00:00Z","timestamp":1600300800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"name":"Unitika Ltd."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Poly\u00ad(2-methoxyethyl acrylate) (PMEA) has attracted attention as a biocompatible polymer that is used as an antithrombotic coating agent for medical devices, such as during artificial heart and lung fabrication. However, PMEA is a viscous liquid polymer with low Tg, and its physical strength is poor even if a cross-linker is used, so it is difficult to make tough and freestanding objects from it. Here, we design and fabricate a biocompatible elastomer made of tough, self-supporting PMEA\u2013silica composites. The toughness of the composite elastomer increases as a function of silica particle filling, and its stress at break is improved from 0.3 to 6.7 MPa. The fracture energy of the composite elastomer with 39.5 vol % silica particles is up to 15 times higher than that of the cross-linked PMEA with no silica particles and the material demonstrates stress\u2013strain behavior that is similar to that of biological soft tissue, which exhibits nonlinear elasticity. In addition, the composite elastomer shows the potential to be an antithrombotic property, while the results of the platelet adhesion test of the composite elastomer show that the number of adhered platelets is not significantly affected by the silica addition. As the composite elastomer can be rapidly three-dimensional-printed into complex geometries with high-resolution features, it is expected to contribute to the development of medical devices from readily available materials.<\/jats:p>","DOI":"10.1021\/acsami.0c11416","type":"journal-article","created":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T09:50:01Z","timestamp":1600336201000},"page":"46621-46628","source":"Crossref","is-referenced-by-count":26,"title":["Tough\nand Three-Dimensional-Printable Poly(2-methoxyethyl acrylate)\u2013Silica\nComposite Elastomer with Antiplatelet Adhesion Property"],"prefix":"10.1021","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2690-1187","authenticated-orcid":true,"given":"Fumio","family":"Asai","sequence":"first","affiliation":[{"name":"Nagoya University , , Furo-cho , Chikusa-ku, ,","place":["Nagoya, Japan, 464-8603"]},{"name":"Unitika Ltd. , , 23, Uji-Kozakura , , ,","place":["Uji-Shi, Kyoto, Japan, 611-0021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Seki","sequence":"additional","affiliation":[{"name":"Nagoya University , , Furo-cho , Chikusa-ku, ,","place":["Nagoya, Japan, 464-8603"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayae","family":"Sugawara-Narutaki","sequence":"additional","affiliation":[{"name":"Nagoya University , , Furo-cho , Chikusa-ku, ,","place":["Nagoya, Japan, 464-8603"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhide","family":"Sato","sequence":"additional","affiliation":[{"name":"Nagoya University Institute for Advanced Research , S-YLC , ,","place":["Nagoya, Japan, 464-8601"]},{"name":"Nagoya University Graduate School of Medicine , , ,","place":["Nagoya, Japan, 466-8550"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3038-846X","authenticated-orcid":true,"given":"Je\u0301re\u0301my","family":"Odent","sequence":"additional","affiliation":[{"name":"University of Mons , , 20, Place du Parc , ,","place":["Mons, Belgium, 7000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5753-7851","authenticated-orcid":true,"given":"Olivier","family":"Coulembier","sequence":"additional","affiliation":[{"name":"University of Mons , , 20, Place du Parc , ,","place":["Mons, Belgium, 7000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1940-7129","authenticated-orcid":true,"given":"Jean-Marie","family":"Raquez","sequence":"additional","affiliation":[{"name":"University of Mons , , 20, Place du Parc , ,","place":["Mons, Belgium, 7000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukikazu","family":"Takeoka","sequence":"additional","affiliation":[{"name":"Nagoya University , , Furo-cho , Chikusa-ku, ,","place":["Nagoya, Japan, 464-8603"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,9,17]]},"reference":[{"key":"2026081714082274100_cit1","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1002\/pat.729","article-title":"Polymers for Tissue Engineering,\nMedical Devices, and Regenerative Medicine. Concise General Review\nof Recent Studies","volume":"17","author":"Jagur-Grodzinski","year":"2006","journal-title":"Polym. Adv. Technol."},{"key":"2026081714082274100_cit2","doi-asserted-by":"publisher","first-page":"5718","DOI":"10.1039\/C4TB00881B","article-title":"Blood Compatible\nMaterials: State of the Art","volume":"2","author":"Liu","year":"2014","journal-title":"J. Mater. Chem.\nB"},{"key":"2026081714082274100_cit3","doi-asserted-by":"publisher","first-page":"8004","DOI":"10.1002\/anie.201400546","article-title":"Protein Interactions with Polymer\nCoatings and Biomaterials","volume":"53","author":"Wei","year":"2014","journal-title":"Angew. Chem., Int.\nEd."},{"key":"2026081714082274100_cit4","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1016\/j.biomaterials.2009.11.022","article-title":"The Effect of Topography of Polymer Surfaces on Platelet\nAdhesion","volume":"31","author":"Koh","year":"2010","journal-title":"Biomaterials"},{"key":"2026081714082274100_cit5","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1002\/smll.200500095","article-title":"No Platelet Can Adhere\ue5f8Largely Improved Blood\nCompatibility on Nanostructured Superhydrophobic Surfaces","volume":"1","author":"Sun","year":"2005","journal-title":"Small"},{"key":"2026081714082274100_cit6","doi-asserted-by":"publisher","first-page":"10467","DOI":"10.1021\/ja9019935","article-title":"Antiplatelet\nand Thermally Responsive Poly\u00ad(N-Isopropylacrylamide) Surface with\nNanoscale Topography","volume":"131","author":"Chen","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"2026081714082274100_cit7","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.colsurfb.2010.10.034","article-title":"On Improving Blood Compatibility: From Bioinspired\nto Synthetic Design and Fabrication of Biointerfacial Topography at\nMicro\/Nano Scales","volume":"85","author":"Chen","year":"2011","journal-title":"Colloids Surf., B"},{"key":"2026081714082274100_cit8","doi-asserted-by":"publisher","first-page":"2144","DOI":"10.1002\/smll.200900345","article-title":"Greatly Improved Blood\nCompatibility by Microscopic Multiscale Design of Surface Architectures","volume":"5","author":"Fan","year":"2009","journal-title":"Small"},{"key":"2026081714082274100_cit9","doi-asserted-by":"publisher","first-page":"14365","DOI":"10.1021\/acsami.9b20264","article-title":"Improving\nMechanical Properties and Biocompatibilities by Highly Oriented Long\nChain Branching Poly\u00ad(Lactic Acid) with Bionic Surface Structures","volume":"12","author":"Li","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"2026081714082274100_cit10","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1002\/adma.201001215","article-title":"Antifouling Coatings: Recent Developments\nin the Design of Surfaces That Prevent Fouling by Proteins, Bacteria,\nand Marine Organisms","volume":"23","author":"Banerjee","year":"2011","journal-title":"Adv. Mater."},{"key":"2026081714082274100_cit11","doi-asserted-by":"publisher","first-page":"15535","DOI":"10.1021\/acs.langmuir.9b01876","article-title":"Synergy between Zwitterionic\nPolymers and Hyaluronic Acid Enhances Antifouling Performance","volume":"35","author":"Xia","year":"2019","journal-title":"Langmuir"},{"key":"2026081714082274100_cit12","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1016\/j.actbio.2010.11.027","article-title":"Effect of Hydrophilic\nPolymer Conjugation on Heat-Induced Conformational Changes in a Protein","volume":"7","author":"Seo","year":"2011","journal-title":"Acta Biomater."},{"key":"2026081714082274100_cit13","doi-asserted-by":"publisher","first-page":"5283","DOI":"10.1016\/j.polymer.2010.08.022","article-title":"Surface Hydration: Principles and\nApplications toward Low-Fouling\/Nonfouling Biomaterials","volume":"51","author":"Chen","year":"2010","journal-title":"Polymer"},{"key":"2026081714082274100_cit14","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1016\/S0142-9612(00)00031-4","article-title":"Blood Compatible Aspects of Poly\u00ad(2-Methoxyethylacrylate)\n(PMEA)\ue5f8Relationship between Protein Adsorption and Platelet\nAdhesion on PMEA Surface","volume":"21","author":"Tanaka","year":"2000","journal-title":"Biomaterials"},{"key":"2026081714082274100_cit15","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1038\/pj.2012.229","article-title":"The Roles\nof Water Molecules at the Biointerface of Medical Polymers","volume":"45","author":"Tanaka","year":"2013","journal-title":"Polym. J."},{"key":"2026081714082274100_cit16","doi-asserted-by":"publisher","first-page":"3750","DOI":"10.1021\/la0625998","article-title":"Time-Resolved\nIn Situ ATR-IR Observations of the Process of Sorption of Water into\na Poly\u00ad(2-Methoxyethyl Acrylate) Film","volume":"23","author":"Morita","year":"2007","journal-title":"Langmuir"},{"key":"2026081714082274100_cit17","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.colsurfb.2017.04.001","article-title":"Water-Immiscible Bioinert\nCoatings and Film Formation from Aqueous Dispersions of Poly\u00ad(2-Methoxyethyl\nAcrylate) Microspheres","volume":"155","author":"Kureha","year":"2017","journal-title":"Colloids Surf., B"},{"key":"2026081714082274100_cit18","doi-asserted-by":"publisher","first-page":"4154","DOI":"10.1021\/acsabm.9b00363","article-title":"Hydration States and Blood Compatibility of Hydrogen-Bonded\nSupramolecular Poly\u00ad(2-Methoxyethyl Acrylate)","volume":"2","author":"Jankova","year":"2019","journal-title":"ACS Appl. Bio Mater."},{"key":"2026081714082274100_cit19","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1021\/acsmaterialslett.9b00520","article-title":"Highly Transparent and Tough Filler Composite Elastomer\nInspired by the Cornea","volume":"2","author":"Watanabe","year":"2020","journal-title":"ACS Mater. Lett."},{"key":"2026081714082274100_cit20","doi-asserted-by":"publisher","first-page":"1701807","DOI":"10.1002\/adfm.201701807","article-title":"Highly\nElastic, Transparent, and Conductive 3D-Printed Ionic Composite Hydrogels","volume":"27","author":"Odent","year":"2017","journal-title":"Adv. Funct. Mater."},{"key":"2026081714082274100_cit21","doi-asserted-by":"publisher","first-page":"40013","DOI":"10.1039\/c9ra09781c","article-title":"Preparation of a Mimetic and Degradable Poly\u00ad(Ethylene\nGlycol) by a Non-Eutectic Mixture of Organocatalysts (NEMO): Via a\nOne-Pot Two-Step Process","volume":"9","author":"Moins","year":"2019","journal-title":"RSC Adv."},{"key":"2026081714082274100_cit22","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1038\/320340a0","article-title":"Phase Behaviour of Concentrated Suspensions of Nearly\nHard Colloidal Spheres","volume":"320","author":"Pusey","year":"1986","journal-title":"Nature"},{"key":"2026081714082274100_cit23","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1126\/science.287.5451.290","article-title":"Direct Observation of Dynamical Heterogeneities in\nColloidal Hard-Sphere Suspensions","volume":"287","author":"Kegel","year":"2000","journal-title":"Science"},{"key":"2026081714082274100_cit24","first-page":"113","article-title":"Developments in the Non-Newtonian Rheology of Glass\nForming Systems","volume-title":"Molecular Dynamics and Relaxation\nPhenomena in Glasses","author":"Woodcock","year":"2008"},{"key":"2026081714082274100_cit25","first-page":"109","article-title":"Characteristics and Behavior of Nanoparticles\nand Its Dispersion Systems","volume-title":"Nanoparticle Technology\nHandbook","author":"Kamiya","year":"2018"},{"key":"2026081714082274100_cit26","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1063\/1.1707495","article-title":"Theory of Filler Reinforcement","volume":"16","author":"Guth","year":"1945","journal-title":"J. Appl. Phys."},{"key":"2026081714082274100_cit27","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/B978-0-12-394584-6.00008-X","article-title":"Reinforcement\nof Elastomers by Particulate Fillers","volume-title":"The\nScience and Technology of Rubber","author":"Donnet","year":"2013"},{"key":"2026081714082274100_cit28","doi-asserted-by":"publisher","first-page":"218","DOI":"10.5254\/rct.13.87995","article-title":"Modified Guth-gold Equation for Carbon Black-filled\nRubbers","volume":"86","author":"Fukahori","year":"2013","journal-title":"Rubber Chem. Technol."},{"key":"2026081714082274100_cit29","doi-asserted-by":"publisher","first-page":"244903","DOI":"10.1063\/1.3148026","article-title":"Entanglement Network in Nanoparticle Reinforced Polymers","volume":"130","author":"Riggleman","year":"2009","journal-title":"J. Chem. Phys."},{"key":"2026081714082274100_cit30","doi-asserted-by":"publisher","first-page":"5857","DOI":"10.1021\/ma200899y","article-title":"Dynamics of Entangled Chains in Polymer\nNanocomposites","volume":"44","author":"Schneider","year":"2011","journal-title":"Macromolecules"},{"key":"2026081714082274100_cit31","doi-asserted-by":"publisher","first-page":"118001","DOI":"10.1103\/PhysRevLett.109.118001","article-title":"Nanoparticle Effect on the Dynamics\nof Polymer Chains and Their Entanglement Network","volume":"109","author":"Li","year":"2012","journal-title":"Phys. Rev. Lett."},{"key":"2026081714082274100_cit32","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1038\/nature03521","article-title":"Nonlinear Elasticity in Biological\nGels","volume":"435","author":"Storm","year":"2005","journal-title":"Nature"},{"key":"2026081714082274100_cit33","doi-asserted-by":"publisher","first-page":"7531","DOI":"10.1021\/acs.macromol.9b01127","article-title":"Architectural Code for Rubber Elasticity: From Supersoft\nto Superfirm Materials","volume":"52","author":"Sheiko","year":"2019","journal-title":"Macromolecules"},{"key":"2026081714082274100_cit34","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/B978-0-12-394584-6.00006-6","article-title":"Rheological Behavior and Processing of Unvulcanized\nRubber","volume-title":"The Science and Technology of Rubber","author":"Roland","year":"2013"},{"key":"2026081714082274100_cit35","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1021\/acsmacrolett.9b00106","article-title":"Strained Bottlebrushes in Super-Soft\nPhysical Networks","volume":"8","author":"Clair","year":"2019","journal-title":"ACS Macro Lett."},{"key":"2026081714082274100_cit36","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1021\/acscentsci.9b01216","article-title":"Bottlebrush\nBridge between Soft Gels and Firm Tissues","volume":"6","author":"Keith","year":"2020","journal-title":"ACS\nCent. Sci."}],"container-title":["ACS Applied Materials &amp; Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.0c11416","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/aamick\/article-pdf\/12\/41\/46621\/9290149\/am0c11416.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/aamick\/article-pdf\/12\/41\/46621\/9290149\/am0c11416.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:33:15Z","timestamp":1786991595000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/aamick\/article\/12\/41\/46621\/869389\/Tough-and-Three-Dimensional-Printable-Poly-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,17]]},"references-count":36,"journal-issue":{"issue":"41","published-online":{"date-parts":[[2020,9,17]]},"published-print":{"date-parts":[[2020,10,14]]}},"URL":"https:\/\/doi.org\/10.1021\/acsami.0c11416","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,17]]}}}