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In this study, HAP was in situ generated on poly\u00ad(l-lactic acid) (PLLA) particles, and then they were used to fabricate a scaffold by selective laser sintering. Detailedly, PLLA particles were first functionalized by dopamine oxide polymerization, which introduced abundance active catechol groups on the particle surface, and subsequently, the catechol groups concentrated Ca2+ ions by chelation in a simulated body fluid solution, and then, Ca2+ ions absorbed PO43\u2013 ions through electrostatic interactions for in situ nucleation of HAP. The results indicated that HAP was homogeneously generated on the PLLA particle surface, and HAP and PLLA exhibited good interfacial bonding in the HAP\/PLLA scaffolds. Meanwhile, the scaffolds displayed excellent bioactivity by inducing apatite precipitation and provided a good environment for human bone mesenchymal stem cell attachment, proliferation, and osteogenic differentiation. More importantly, the ingrowth of blood vessel and the formation of new bone could be stimulated by the scaffolds in vivo, and the bone volume fraction and bone mineral density increased by 44.44 and 41.73% compared with the pure PLLA scaffolds, respectively. Serum biochemical indexes fell within the normal range, which indicated that there was no harmful effect on the normal functioning of the body after implanting the scaffold.<\/jats:p>","DOI":"10.1021\/acsami.0c13768","type":"journal-article","created":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T13:55:09Z","timestamp":1600350909000},"page":"46743-46755","source":"Crossref","is-referenced-by-count":85,"title":["In\nSitu Generation of Hydroxyapatite on Biopolymer\nParticles for Fabrication of Bone Scaffolds Owning Bioactivity"],"prefix":"10.1021","volume":"12","author":[{"given":"Pei","family":"Feng","sequence":"first","affiliation":[{"name":"Central South University , , ,","place":["Changsha, China, 410083"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuping","family":"Peng","sequence":"additional","affiliation":[{"name":"Central South University , , ,","place":["Changsha, China, 410013"]},{"name":"Jiangxi University of Science and Technology , , ,","place":["Nanchang, China, 330013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2029-5112","authenticated-orcid":true,"given":"Cijun","family":"Shuai","sequence":"additional","affiliation":[{"name":"Central South University , , ,","place":["Changsha, China, 410083"]},{"name":"Jiangxi University of Science and Technology , , ,","place":["Nanchang, China, 330013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1938-7538","authenticated-orcid":true,"given":"Chengde","family":"Gao","sequence":"additional","affiliation":[{"name":"Central South University , , ,","place":["Changsha, China, 410083"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Yang","sequence":"additional","affiliation":[{"name":"Central South University , , ,","place":["Changsha, China, 410083"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizhen","family":"Bin","sequence":"additional","affiliation":[{"name":"Central South University , , ,","place":["Changsha, China, 410013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjie","family":"Min","sequence":"additional","affiliation":[{"name":"Central South University , , ,","place":["Changsha, China, 410078"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,9,17]]},"reference":[{"key":"2026081714120242500_cit1","doi-asserted-by":"publisher","first-page":"eaat0713","DOI":"10.1126\/sciadv.aat0713","article-title":"Artificial\n3D Hierarchical and Isotropic Porous Polymeric Materials","volume":"4","author":"Chisca","year":"2018","journal-title":"Sci. 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