{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T05:22:39Z","timestamp":1785388959815,"version":"3.55.0"},"reference-count":66,"publisher":"American Chemical Society (ACS)","issue":"3","license":[{"start":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T00:00:00Z","timestamp":1610323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T00:00:00Z","timestamp":1610323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T00:00:00Z","timestamp":1610323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Appl. Mater. Interfaces"],"published-print":{"date-parts":[[2021,1,27]]},"DOI":"10.1021\/acsami.0c18926","type":"journal-article","created":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T07:54:44Z","timestamp":1610610884000},"page":"3559-3575","source":"Crossref","is-referenced-by-count":65,"title":["Design, Optimization, and Characterization of Lactoferrin-Loaded Chitosan\/TPP and Chitosan\/Sulfobutylether-\u03b2-cyclodextrin Nanoparticles as a Pharmacological Alternative for Keratoconus Treatment"],"prefix":"10.1021","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1241-9936","authenticated-orcid":true,"given":"Rub\u00e9n","family":"Varela-Fern\u00e1ndez","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Pharmacy and Pharmaceutical Technology, University of Santiago de Compostela (USC), Campus vida, Santiago de Compostela 15782, Spain"},{"name":"Clinical Neurosciences Group, University Clinical Hospital, Health Research Institute of Santiago de Compostela (IDIS), Traves\u00eda da Choupana s\/n, Santiago de Compostela 15706, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8351-3180","authenticated-orcid":true,"given":"Xurxo","family":"Garc\u00eda-Otero","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Pharmacy and Pharmaceutical Technology, University of Santiago de Compostela (USC), Campus vida, Santiago de Compostela 15782, Spain"},{"name":"Molecular Imaging Group, University Clinical Hospital, Health Research Institute of Santiago de Compostela (IDIS), Traves\u00eda da Choupana s\/n, Santiago de Compostela 15706, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"D\u00edaz-Tom\u00e9","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Pharmacy and Pharmaceutical Technology, University of Santiago de Compostela (USC), Campus vida, Santiago de Compostela 15782, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ux\u00eda","family":"Regueiro","sequence":"additional","affiliation":[{"name":"Clinical Neurosciences Group, University Clinical Hospital, Health Research Institute of Santiago de Compostela (IDIS), Traves\u00eda da Choupana s\/n, Santiago de Compostela 15706, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maite","family":"L\u00f3pez-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Clinical Neurosciences Group, University Clinical Hospital, Health Research Institute of Santiago de Compostela (IDIS), Traves\u00eda da Choupana s\/n, Santiago de Compostela 15706, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Gonz\u00e1lez-Barcia","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Group, University Clinical Hospital, Health Research Institute of Santiago de Compostela (IDIS), Traves\u00eda da Choupana s\/n, Santiago de Compostela 15706, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Isabel","family":"Lema","sequence":"additional","affiliation":[{"name":"Department of Surgery and Medical-Surgical Specialties. Ophthalmology Area, University of Santiago de Compostela (USC), Campus Vida, Santiago de Compostela 15706, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9030-2253","authenticated-orcid":true,"given":"Francisco Javier","family":"Otero-Espinar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Pharmacy and Pharmaceutical Technology, University of Santiago de Compostela (USC), Campus vida, Santiago de Compostela 15782, Spain"},{"name":"Paraquasil Group, University Clinical Hospital, Health Research Institute of Santiago de Compostela (IDIS), Traves\u00eda da Choupana s\/n, Santiago de Compostela 15706, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2021,1,11]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.5497\/wjp.v2.i2.47"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.05.040"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1088\/0957-4484\/19\/18\/185101"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2007.11.017"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2016.12.015"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2010.04.006"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000000723"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2018.05.002"},{"key":"ref9\/cit9","first-page":"2055","volume":"16","author":"Lema I.","year":"2010","journal-title":"Mol. Vis."},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.66.149"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-1882"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2008.07.007"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-13525-7"},{"key":"ref14\/cit14","unstructured":"Gesto, M. I. L.; S\u00e1nchez, J. A. C.; Moreiras, T. S.; Perez, F. C. Biomarkers for Diagnosis and Prognosis of Corneal Ectatic Disorders. US Patent US15\/551,3862018."},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1159\/000329794"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2011.08.003"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.33.2469"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2016.04.115"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.4103\/2230-973X.82432"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2011.01.044"},{"key":"ref21\/cit21","unstructured":"Guideline, I.C.H. Stability Testing of New Drug Substances and Products, Q1A (R2); ICH Harmonised Tripartite, 2006; p 20."},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1208\/ps010311"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.2174\/156720109787048302"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2010.01.063"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-6915(96)00100-7"},{"key":"ref26\/cit26","doi-asserted-by":"crossref","unstructured":"Loprieno, N. Alternative Methodologies for the Safety Evaluation of Chemicals in the Cosmetic Industry; CRC Press, 2019; p 233.","DOI":"10.1201\/9780429283765"},{"key":"ref27\/cit27","doi-asserted-by":"crossref","unstructured":"Salem, H.; Katz, S. A. Alternative Toxicological Methods; CRC Press, 2003; p 618.","DOI":"10.1201\/9780203008799"},{"key":"ref128\/cit128","first-page":"271","volume":"6","author":"Tchao R.","year":"1988","journal-title":"Alternative Methods in Toxicology"},{"key":"ref129\/cit129","doi-asserted-by":"publisher","DOI":"10.1016\/0887-2333(94)90159-7"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1177\/026119290503301s09"},{"key":"ref29\/cit29","first-page":"673","volume-title":"Fundamentals of Toxicologic Pathology","author":"Wallig M. A.","year":"2018","edition":"3"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/0278-6915(85)90030-4"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/0887-2333(90)90147-L"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/0887-2333(93)90055-A"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.3390\/biomimetics4020032"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2011.12.063"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.2174\/156720109787048285"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1021\/mp300382n"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1039\/c2an35863h"},{"key":"ref38\/cit38","first-page":"772","volume":"58","author":"Fern\u00e1ndez-Ferreiro A.","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2016.06.007"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1162\/153535003322556877"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2010.01.007"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.3.4.463"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2009.04.009"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1023\/B:PHAM.0000012145.49054.6c"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2005.03.027"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2011.04.031"},{"key":"ref48\/cit48","first-page":"85","volume":"3","author":"Sohrabi S. M.","year":"2014","journal-title":"Mol. Biol. Res. Commun."},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2009.08.049"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2007.03.005"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5260976"},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/B978-1-85617-556-2.00003-2","volume-title":"Cohesive Sediments in Open Channels","author":"Partheniades E.","year":"2009"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-23064-4"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1080\/03639040801974295"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2009.09.004"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(01)75844-4"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2011.586334"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1023\/B:PHAM.0000026432.75781.cb"},{"key":"ref59\/cit59","doi-asserted-by":"crossref","DOI":"10.1002\/9781119962977","volume-title":"Chitosan-Based Systems for Biopharmaceuticals: Delivery, Targeting and Polymer Therapeutics","author":"Sarmento B.","year":"2012"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2005.07.008"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1002\/jps.21783"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2013.07.027"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12030269"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2013.02.015"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2011.01.044"}],"container-title":["ACS Applied Materials &amp; Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.0c18926","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T10:24:53Z","timestamp":1681727093000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsami.0c18926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,11]]},"references-count":66,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,1,27]]}},"alternative-id":["10.1021\/acsami.0c18926"],"URL":"https:\/\/doi.org\/10.1021\/acsami.0c18926","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,11]]}}}