{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:09:51Z","timestamp":1792098591224,"version":"4.4.0"},"reference-count":63,"publisher":"American Chemical Society (ACS)","issue":"33","license":[{"start":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T00:00:00Z","timestamp":1628640000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T00:00:00Z","timestamp":1628640000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T00:00:00Z","timestamp":1628640000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21525105"],"award-info":[{"award-number":["21525105"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21778079"],"award-info":[{"award-number":["21778079"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21977126"],"award-info":[{"award-number":["21977126"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021B1515020102"],"award-info":[{"award-number":["2021B1515020102"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009334","name":"Pearl River S&T Nova Program of Guangzhou","doi-asserted-by":"crossref","award":["201806010136"],"award-info":[{"award-number":["201806010136"]}],"id":[{"id":"10.13039\/501100009334","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Appl. Mater. Interfaces"],"published-print":{"date-parts":[[2021,8,25]]},"DOI":"10.1021\/acsami.1c07223","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T17:54:01Z","timestamp":1628704441000},"page":"38959-38968","source":"Crossref","is-referenced-by-count":42,"title":["Autophagy-Dependent Apoptosis Induced by Apoferritin\u2013Cu(II) Nanoparticles in Multidrug-Resistant Colon Cancer Cells"],"prefix":"10.1021","volume":"13","author":[{"given":"Kai","family":"Xiong","sequence":"first","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhou","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5258-0260","authenticated-orcid":true,"given":"Johannes","family":"Karges","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kejie","family":"Du","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinchao","family":"Shen","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingwei","family":"Lin","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangmian","family":"Wei","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfeng","family":"Kou","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangnian","family":"Ji","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4153-5303","authenticated-orcid":true,"given":"Hui","family":"Chao","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2021,8,11]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2019.04.005"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2019.01.018"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.05.051"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt249"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201900387"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.19187"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2019.100645"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c01741"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00271"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2019.07.008"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202006089"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1039\/D0QI01430C"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1039\/C6SC00268D"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2019.03.002"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/jm1009296"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-0139"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-017-0012-4"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4504-5"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.7150\/thno.17322"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11085"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.9b01156"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201807305"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c00221"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2019.08.021"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1039\/C8SC01142G"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1039\/C8CC02795A"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1039\/D0QI00224K"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.0c01880"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202014959"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12123594"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1021\/cr400135x"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17050745"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2020.118893"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201702446"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b00939"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b02047"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.02.018"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b02622"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2017.1373163"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.7b00132"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b16910"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1038\/s41570-019-0088-0"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b11798"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1039\/b705326f"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b07038"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1996.0007"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.14.119"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1388"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2010.03.011"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-010-9256-x"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1107\/S0108767394005726"},{"key":"ref52\/cit52","volume-title":"Shelxs 97, Program for X-Ray Crystal Structure Determination","author":"Sheldrick G. M.","year":"1997"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2021.111380"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2014.08.006"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2008.07.004"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.77"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2011.27"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1126\/science.1096645"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14658"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1039\/C8SC04520H"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1039\/C7SC05040B"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09566-3"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2017.06.001"}],"container-title":["ACS Applied Materials & Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.1c07223","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T15:57:09Z","timestamp":1682438229000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsami.1c07223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,11]]},"references-count":63,"journal-issue":{"issue":"33","published-print":{"date-parts":[[2021,8,25]]}},"alternative-id":["10.1021\/acsami.1c07223"],"URL":"https:\/\/doi.org\/10.1021\/acsami.1c07223","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,11]]}}}