{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:17:00Z","timestamp":1788455820504,"version":"build-2803163510"},"reference-count":72,"publisher":"American Chemical Society (ACS)","issue":"38","license":[{"start":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T00:00:00Z","timestamp":1631750400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T00:00:00Z","timestamp":1631750400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T00:00:00Z","timestamp":1631750400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100002865","name":"Chongqing Science and Technology Commission","doi-asserted-by":"publisher","award":["CSTC2018JCYJAX0298"],"award-info":[{"award-number":["CSTC2018JCYJAX0298"]}],"id":[{"id":"10.13039\/501100002865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011786","name":"Chongqing Municipal Human Resources and Social Security Bureau","doi-asserted-by":"publisher","award":["2007010004022114"],"award-info":[{"award-number":["2007010004022114"]}],"id":[{"id":"10.13039\/501100011786","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32030103"],"award-info":[{"award-number":["32030103"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"State Key Laboratory of Silkworm Genome Biology","award":["SKLSGB1819-1"],"award-info":[{"award-number":["SKLSGB1819-1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Appl. Mater. Interfaces"],"published-print":{"date-parts":[[2021,9,29]]},"DOI":"10.1021\/acsami.1c08409","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T07:20:18Z","timestamp":1631776818000},"page":"45175-45190","source":"Crossref","is-referenced-by-count":32,"title":["Fabrication of a Silk Sericin Hydrogel System Delivering Human Lactoferrin Using Genetically Engineered Silk with Improved Bioavailability to Alleviate Chemotherapy-Induced Immunosuppression"],"prefix":"10.1021","volume":"13","author":[{"given":"Sheng","family":"Xu","sequence":"first","affiliation":[{"name":"Research Centre for Regenerative Medicine, Guangxi Engineering Center in Biomedical Material for Tissue and Organ Regeneration, Guangxi Medical University, Nanning, Guangxi 530021, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanhuan","family":"Tan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Silkworm Genome Biology, Chongqing Engineering and Technology, Research Center for Novel Silk Materials, Biological Science Research Center, Southwest University, Chongqing 400715, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Silkworm Genome Biology, Chongqing Engineering and Technology, Research Center for Novel Silk Materials, Biological Science Research Center, Southwest University, Chongqing 400715, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Silkworm Genome Biology, Chongqing Engineering and Technology, Research Center for Novel Silk Materials, Biological Science Research Center, Southwest University, Chongqing 400715, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Tian","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Silkworm Genome Biology, Chongqing Engineering and Technology, Research Center for Novel Silk Materials, Biological Science Research Center, Southwest University, Chongqing 400715, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanting","family":"Ji","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Silkworm Genome Biology, Chongqing Engineering and Technology, Research Center for Novel Silk Materials, Biological Science Research Center, Southwest University, Chongqing 400715, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5618-0472","authenticated-orcid":true,"given":"Ping","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Silkworm Genome Biology, Chongqing Engineering and Technology, Research Center for Novel Silk Materials, Biological Science Research Center, Southwest University, Chongqing 400715, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9263-2886","authenticated-orcid":true,"given":"Qingyou","family":"Xia","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Silkworm Genome Biology, Chongqing Engineering and Technology, Research Center for Novel Silk Materials, Biological Science Research Center, Southwest University, Chongqing 400715, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7633-8284","authenticated-orcid":true,"given":"Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Silkworm Genome Biology, Chongqing Engineering and Technology, Research Center for Novel Silk Materials, Biological Science Research Center, Southwest University, Chongqing 400715, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2021,9,16]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2015.04.026"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12034"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa8172"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1126\/science.1240537"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2015.04.012"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-16-0048"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23071801"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.2579"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2011.03.007"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0709256105"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2015.06.009"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.00731"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-2008"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiotec.2013.09.011"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-014-9779-7"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.3390\/nu10091228"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M107724200"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1007\/s10059-009-0102-3"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2017.08.151"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-005-5371-1"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1126\/science.1214804"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201003963"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(01)00239-3"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.03.052"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2008.11.018"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.04.043"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2018.08.030"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2018.08.031"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2014.06.031"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.11.037"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1039\/C9BM01478K"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1039\/C9BM01285K"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1186\/s13036-019-0186-z"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15902"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.3390\/polym12112537"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00660"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2016.04.068"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1038\/35040504"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00295-9"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318244dd67"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2604"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2008.07.020"},{"key":"ref44\/cit44","first-page":"1452","volume":"16","author":"Razavi B. M.","year":"2017","journal-title":"Iran J. Pharm. Res."},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1038\/srep12374"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.04.099"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2019.115039"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22650"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvt073"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1080\/10837450.2019.1621897"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2007.05.019"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b01462"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2005.05.085"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(02)74103-9"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.9.4.425"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2013.09.038"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.04.101"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2005.14.548"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.42"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1039\/D0FO02670K"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.06.016"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.115957"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1039\/D1FO01257F"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2019.00047"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1078\/0171-2985-00233"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.02.016"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.06.045"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1038\/srep16323"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23102668"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1007\/BF01967620"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1038\/srep07064"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.01.045"}],"container-title":["ACS Applied Materials & Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.1c08409","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T20:35:46Z","timestamp":1682627746000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsami.1c08409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,16]]},"references-count":72,"journal-issue":{"issue":"38","published-print":{"date-parts":[[2021,9,29]]}},"alternative-id":["10.1021\/acsami.1c08409"],"URL":"https:\/\/doi.org\/10.1021\/acsami.1c08409","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,16]]}}}