{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:53:52Z","timestamp":1789988032977,"version":"4.0.1"},"reference-count":64,"publisher":"American Chemical Society (ACS)","issue":"1","license":[{"start":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T00:00:00Z","timestamp":1640822400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T00:00:00Z","timestamp":1640822400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T00:00:00Z","timestamp":1640822400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","award":["F.4-1\/2006 [BSR]\/7-209\/2009 [BSR]"],"award-info":[{"award-number":["F.4-1\/2006 [BSR]\/7-209\/2009 [BSR]"]}],"id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","award":["F.4-7\/2015\/DRS-II (SAP-II)"],"award-info":[{"award-number":["F.4-7\/2015\/DRS-II (SAP-II)"]}],"id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology , Ministry of Science and Technology","doi-asserted-by":"publisher","award":["BT\/HRD\/35\/01\/01\/2017"],"award-info":[{"award-number":["BT\/HRD\/35\/01\/01\/2017"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology","doi-asserted-by":"publisher","award":["CRG\/2019\/004842"],"award-info":[{"award-number":["CRG\/2019\/004842"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Appl. Mater. Interfaces"],"published-print":{"date-parts":[[2022,1,12]]},"DOI":"10.1021\/acsami.1c15305","type":"journal-article","created":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T13:33:26Z","timestamp":1640871206000},"page":"69-93","source":"Crossref","is-referenced-by-count":46,"title":["siRNA Mediated GSK3\u03b2 Knockdown Targets Insulin Signaling Pathway and Rescues Alzheimer\u2019s Disease Pathology: Evidence from <i>In Vitro<\/i> and <i>In Vivo<\/i> Studies"],"prefix":"10.1021","volume":"14","author":[{"given":"Smriti","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Panjab University, Chandigarh 160014, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal","family":"Singh","sequence":"additional","affiliation":[{"name":"National Agri-Food Biotechnology Institute, Sector 81, S.A.S. Nagar, Mohali 140306, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subramaniam","family":"Ganesh","sequence":"additional","affiliation":[{"name":"Department of Biological Science and Bioengineering, Indian Institute of Technology, Kanpur 208016, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2384-4487","authenticated-orcid":true,"given":"Nitin K.","family":"Singhal","sequence":"additional","affiliation":[{"name":"National Agri-Food Biotechnology Institute, Sector 81, S.A.S. Nagar, Mohali 140306, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6242-5811","authenticated-orcid":true,"given":"Rajat","family":"Sandhir","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Panjab University, Chandigarh 160014, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2021,12,30]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.03.001"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-7508-8_8"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61349-9"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002369"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2005-8304"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2005-7107"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1177\/193229680800200619"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2005.03155.x"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v6.i12.1223"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2004.02.048"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1007\/s007020200082"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.110.087031"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.2174\/1567205013666160129095924"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-0985-0"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-015-9132-3"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-012-0877-9"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2012.12.005"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2014.08.007"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-016-0674-0"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00204"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1186\/s43141-021-00163-w"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22115911"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1039\/C7RA00810D"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jece.2016.02.035"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-009-3319-2"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.7150\/thno.17841"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.2006.00795.x"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.08.031"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4321-06.2007"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M707108200"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-10-j0001.2002"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-7703com"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160841"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1111\/febs.13698"},{"key":"ref35\/cit35","first-page":"458","volume":"59","author":"Miranda N.","year":"2007","journal-title":"Rev. Invest. Clin."},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2329"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00050.2013"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1159\/000067426"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(00)01229-5"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2009-1191"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2016.186"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2009-1004"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0889-12.2012"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1038\/bjp.2008.2"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1002\/hup.710"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(86)90381-3"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2015.00055"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2004.06.006"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/0023-9690(77)90054-6"},{"key":"ref50\/cit50","first-page":"87","volume":"2","author":"Lipina T. V.","year":"2016","journal-title":"Opera Medica Physiol."},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0889-12.2012"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.04139.x"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.08m04606"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.110.080044"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1172\/JCI64516"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1021\/nn1006368"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1007\/s12274-008-8021-8"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1021\/la801744a"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/30.9.e36"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.3791\/52434"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.3791\/55523"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1016\/0023-9690(77)90054-6"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20181415"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1007\/s12154-009-0027-5"}],"container-title":["ACS Applied Materials &amp; Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.1c15305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T22:55:10Z","timestamp":1682549710000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsami.1c15305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,30]]},"references-count":64,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1,12]]}},"alternative-id":["10.1021\/acsami.1c15305"],"URL":"https:\/\/doi.org\/10.1021\/acsami.1c15305","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,30]]}}}