{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:05:42Z","timestamp":1787069142980,"version":"build-2736575974"},"reference-count":72,"publisher":"American Chemical Society (ACS)","issue":"51","license":[{"start":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T00:00:00Z","timestamp":1639612800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T00:00:00Z","timestamp":1639612800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T00:00:00Z","timestamp":1639612800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001869","name":"Academia Sinica","doi-asserted-by":"publisher","award":["AS-106-TP-L13"],"award-info":[{"award-number":["AS-106-TP-L13"]}],"id":[{"id":"10.13039\/501100001869","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 106-2628-M-001-002-MY3"],"award-info":[{"award-number":["MOST 106-2628-M-001-002-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Appl. Mater. Interfaces"],"published-print":{"date-parts":[[2021,12,29]]},"DOI":"10.1021\/acsami.1c18754","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T13:35:31Z","timestamp":1639661731000},"page":"60894-60906","source":"Crossref","is-referenced-by-count":17,"title":["Polyglutamine-Specific Gold Nanoparticle Complex Alleviates Mutant Huntingtin-Induced Toxicity"],"prefix":"10.1021","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2979-7466","authenticated-orcid":true,"given":"Devi","family":"Wahyuningtyas","sequence":"first","affiliation":[{"name":"Institute of Chemistry, Academia Sinica, No. 128, Sec. 2, Academia Road, Nankang District, Taipei 11529, Taiwan"},{"name":"Sustainable Chemical Science and Technology, Taiwan International Graduate Program, Academia Sinica, No. 128, Sec. 2, Academia Road, Nankang District, Taipei 11529, Taiwan"},{"name":"Department of Applied Chemistry, National Yang Ming Chiao Tung University, Science Building 2, 1001 Ta Hsueh Road, Hsinchu 300, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Hao","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, Academia Sinica, No. 128, Sec. 2, Academia Road, Nankang District, Taipei 11529, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruei-Yu","family":"He","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, Academia Sinica, No. 128, Sec. 2, Academia Road, Nankang District, Taipei 11529, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung-An","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, Academia Sinica, No. 128, Sec. 2, Academia Road, Nankang District, Taipei 11529, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Kang","family":"Tsao","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology, Academia Sinica, No. 128, Sec. 2, Academia Road, Nankang District, Taipei 11529, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Jung","family":"He","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, Academia Sinica, No. 128, Sec. 2, Academia Road, Nankang District, Taipei 11529, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chu-Yi","family":"Yu","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, Academia Sinica, No. 128, Sec. 2, Academia Road, Nankang District, Taipei 11529, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Chao","family":"Lu","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, Academia Sinica, No. 128, Sec. 2, Academia Road, Nankang District, Taipei 11529, Taiwan"},{"name":"Chemical Biology and Molecular Biophysics, Taiwan International Graduate Program, Academia Sinica, No. 128, Sec. 2, Academia Road, Nankang District, Taipei 11529, Taiwan"},{"name":"Department and Graduate Institute of Pharmacology, National Taiwan University, 11F, No. 1, Section 1, Ren\u2019ai Road, Zhongzheng\rDistrict, Taipei 10051, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Cai","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, Academia Sinica, No. 128, Sec. 2, Academia Road, Nankang District, Taipei 11529, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Hann","family":"Wang","sequence":"additional","affiliation":[{"name":"Research Center for Applied Sciences, Academia Sinica, No. 128, Sec. 2, Academia Road, Nankang District, Taipei 115, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ka Chon","family":"Ng","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, Academia Sinica, No. 128, Sec. 2, Academia Road, Nankang District, Taipei 11529, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8249-0124","authenticated-orcid":true,"given":"Bryan","family":"Po-Wen Chen","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, Academia Sinica, No. 128, Sec. 2, Academia Road, Nankang District, Taipei 11529, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3002-0526","authenticated-orcid":true,"given":"Pei-Kuen","family":"Wei","sequence":"additional","affiliation":[{"name":"Research Center for Applied Sciences, Academia Sinica, No. 128, Sec. 2, Academia Road, Nankang District, Taipei 115, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0856-214X","authenticated-orcid":true,"given":"Jiun-Jie","family":"Shie","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, Academia Sinica, No. 128, Sec. 2, Academia Road, Nankang District, Taipei 11529, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6633-8985","authenticated-orcid":true,"given":"Chun-Hong","family":"Kuo","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, Academia Sinica, No. 128, Sec. 2, Academia Road, Nankang District, Taipei 11529, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. Henry","family":"Sun","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology, Academia Sinica, No. 128, Sec. 2, Academia Road, Nankang District, Taipei 11529, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4847-7126","authenticated-orcid":true,"given":"Joseph","family":"Jen-Tse Huang","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, Academia Sinica, No. 128, Sec. 2, Academia Road, Nankang District, Taipei 11529, Taiwan"},{"name":"Department of Applied Chemistry, National Chiayi University, No. 300, University Road, Chiayi 600, Taiwan"},{"name":"Neuroscience Program of Academia Sinica, Academia Sinica, No. 128, Sec. 2, Academia Road, Nankang, Taipei 11529, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2021,12,16]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.56"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-013-1125-6"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.5"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2011.05.008"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.75.101304.123901"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.4161\/pri.2.3.7488"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1039\/c9cs00199a"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2011.12.013"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1999.0453"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1515\/bc.2000.114"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.182276099"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb1215"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m109.084434"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm311"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1830"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2018.08.019"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001717"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2012.06.017"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.110138997"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.182426599"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408936102"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1038\/ng1362"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b06510"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/acsanm.7b00245"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b06853"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.7b02202"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.8b01196"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/ja8041806"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.reactfunctpolym.2016.04.003"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.09.014"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201007824"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201601666"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.7b00238"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11762-0"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.8b03644"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201603139"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.3233\/jad-2010-1221"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5334.1990"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(00)80513-9"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201900242"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201901165"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201201068"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2017.06.093"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2016.07.066"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1039\/c9tb02271f"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.s140734"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2011.03.020"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/s0168-3659(03)00076-2"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2006.02.009"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1023\/a:1014861900478"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.187"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.5681\/bi.2011.004"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302050"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201700983"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1021\/la049172q"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2006.08.005"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b06903"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1021\/bc800016y"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.9b01547"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/s0927-7757(98)00207-6"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2009.08.034"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1039\/c5cc00513b"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-018-2854-4"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3810"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m111.252577"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinsphys.2016.07.007"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.0c00366"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2016.05.072"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1002\/app.42096"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-013-0184-7"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.621996"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1021\/ac0613582"}],"container-title":["ACS Applied Materials &amp; Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.1c18754","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T11:07:56Z","timestamp":1682593676000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsami.1c18754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,16]]},"references-count":72,"journal-issue":{"issue":"51","published-print":{"date-parts":[[2021,12,29]]}},"alternative-id":["10.1021\/acsami.1c18754"],"URL":"https:\/\/doi.org\/10.1021\/acsami.1c18754","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,16]]}}}