{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T23:46:55Z","timestamp":1784677615447,"version":"3.55.0"},"reference-count":66,"publisher":"American Chemical Society (ACS)","issue":"17","license":[{"start":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T00:00:00Z","timestamp":1650585600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T00:00:00Z","timestamp":1650585600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T00:00:00Z","timestamp":1650585600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2021R1A2C2095113"],"award-info":[{"award-number":["2021R1A2C2095113"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2021R1A6A1A03046418"],"award-info":[{"award-number":["2021R1A6A1A03046418"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Appl. Mater. Interfaces"],"published-print":{"date-parts":[[2022,5,4]]},"DOI":"10.1021\/acsami.2c01738","type":"journal-article","created":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T18:55:23Z","timestamp":1650653723000},"page":"19139-19153","source":"Crossref","is-referenced-by-count":5,"title":["Pore Size-Dependent Stereoscopic Hydrogels Enhance the Therapeutic Efficiency of <i>Botulinum Toxin<\/i> for the Treatment of Nerve-Related Diseases"],"prefix":"10.1021","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6164-2566","authenticated-orcid":true,"given":"Jeong Man","family":"An","sequence":"first","affiliation":[{"name":"Department of Bioengineering, College of Engineering, Hanyang University, Seoul 04763, Republic of Korea"},{"name":"Department of Chemical and Biological Engineering, Korea National University of Transportation, Chungju 27469, Republic of Korea"},{"name":"KB Biomed Inc., Chungju 27469, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8632-2355","authenticated-orcid":true,"given":"S. M. Shatil","family":"Shahriar","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Engineering, Korea National University of Transportation, Chungju 27469, Republic of Korea"},{"name":"KB Biomed Inc., Chungju 27469, Republic of Korea"},{"name":"Department of Surgery-Transplant and Mary & Dick Holland Regenerative Medicine Program, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198-5940, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7691-0447","authenticated-orcid":true,"given":"Dong Yun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, College of Engineering, and BK FOUR Biopharmaceutical Innovation Leader for Education and Research Group, Hanyang University, Seoul 04763, Republic of Korea"},{"name":"Institute of Nano Science and Technology (INST), Hanyang University, Seoul 04763, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3250-3396","authenticated-orcid":true,"given":"Seung Rim","family":"Hwang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Chosun University, 309 Pilmun-daero, Dong-gu, Gwangju 61452, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8336-3592","authenticated-orcid":true,"given":"Yong-kyu","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Engineering, Korea National University of Transportation, Chungju 27469, Republic of Korea"},{"name":"KB Biomed Inc., Chungju 27469, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2022,4,22]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.4.712"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/78005"},{"issue":"2","key":"ref3\/cit3","first-page":"31","volume":"7","author":"Walker T. J.","year":"2014","journal-title":"J. Clin. Aesthet. Dermatol."},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14130"},{"issue":"3","key":"ref5\/cit5","first-page":"1489","volume":"280","author":"Coffield J. A.","year":"1997","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref6\/cit6","volume-title":"Cellular and Molecular Neurophysiology","author":"Hammond C.","edition":"4"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.60343"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1007\/BF01575751"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1126\/science.1214270"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1126\/science.1219602"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.5820"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-015-0567-5"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1093\/femspd\/ftv054"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-33570-9_2"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003690"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(82)90061-4"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1007\/s10930-013-9465-6"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2014.02.004"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1038\/srep17795"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.asj.2009.09.014"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.11.4090"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/974943"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00064-y"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2011.12.037"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(83)91300-8"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1093\/protein\/gzq093"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(85)90033-1"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-14997-3"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(03)00210-5"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2005.03.022"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2000.80.2.717"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1126\/science.785600"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.6.10.1383"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/802893"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S1612"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.17245\/jdapm.2016.16.3.151"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.3390\/toxins11080459"},{"key":"ref38\/cit38","first-page":"734","volume":"79","author":"Scott A. B.","year":"1981","journal-title":"Trans. Am. Ophthalmol. Soc."},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-48275-1"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-33119-1"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.2018.126"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.2009.813"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2015.07.013"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(71)90129-8"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2017.07.011"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.3390\/toxins5020249"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200002000-00050"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2003.034702"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090252"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1159\/000083259"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1002\/etc.5620150307"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1038\/s41428-019-0235-y"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-35984-2"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c21938"},{"issue":"4","key":"ref55\/cit55","first-page":"181","volume":"17","author":"Kim A. R.","year":"2013","journal-title":"Biomater. Res."},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.3390\/polym11040742"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.3390\/nano9040532"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202008364"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.0c00889"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202008395"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.10.001"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1007\/BF02639379"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.780"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1080\/01480540701375091"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.1c00832"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c22170"}],"container-title":["ACS Applied Materials &amp; Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.2c01738","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.2c01738","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T18:33:17Z","timestamp":1682447597000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsami.2c01738"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,22]]},"references-count":66,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2022,5,4]]}},"alternative-id":["10.1021\/acsami.2c01738"],"URL":"https:\/\/doi.org\/10.1021\/acsami.2c01738","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,22]]}}}