{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T13:17:44Z","timestamp":1783343864805,"version":"3.54.6"},"reference-count":50,"publisher":"American Chemical Society (ACS)","issue":"41","license":[{"start":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T00:00:00Z","timestamp":1665100800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T00:00:00Z","timestamp":1665100800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T00:00:00Z","timestamp":1665100800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2021YFC2300603"],"award-info":[{"award-number":["2021YFC2300603"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21902088"],"award-info":[{"award-number":["21902088"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22072075"],"award-info":[{"award-number":["22072075"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007785","name":"Jinan Science and Technology Bureau","doi-asserted-by":"publisher","award":["2020GXRC022"],"award-info":[{"award-number":["2020GXRC022"]}],"id":[{"id":"10.13039\/100007785","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Project for Scientific Research Innovation Team of Young Scholars in Colleges and Universities of Shandong Province","award":["2020KJC001"],"award-info":[{"award-number":["2020KJC001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Appl. Mater. Interfaces"],"published-print":{"date-parts":[[2022,10,19]]},"DOI":"10.1021\/acsami.2c11203","type":"journal-article","created":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T19:24:31Z","timestamp":1665170671000},"page":"46176-46187","source":"Crossref","is-referenced-by-count":14,"title":["Enhanced Delivery of TLR7\/8 Agonists by Metal\u2013Organic Frameworks for Hepatitis B Virus Cure"],"prefix":"10.1021","volume":"14","author":[{"given":"Liyuan","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Cheeloo Medical College, Shandong University, Jinan, Shandong 250012, China"},{"name":"Department of Microbiology, Weifang Medical University, Weifang, Shandong 261042, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiqiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China"},{"name":"Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Science, Jinan, Shandong 250117, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Sun","sequence":"additional","affiliation":[{"name":"Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Cheeloo Medical College, Shandong University, Jinan, Shandong 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuanchang","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Cheeloo Medical College, Shandong University, Jinan, Shandong 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiyue","family":"Ren","sequence":"additional","affiliation":[{"name":"Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Cheeloo Medical College, Shandong University, Jinan, Shandong 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Cheeloo Medical College, Shandong University, Jinan, Shandong 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqi","family":"Peng","sequence":"additional","affiliation":[{"name":"Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Cheeloo Medical College, Shandong University, Jinan, Shandong 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yankun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Cheeloo Medical College, Shandong University, Jinan, Shandong 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Cheeloo Medical College, Shandong University, Jinan, Shandong 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyang","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Cheeloo Medical College, Shandong University, Jinan, Shandong 250012, China"},{"name":"Key Laboratory of Infection and Immunity of Shandong Province, Shandong University, Jinan, Shandong 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifen","family":"Gao","sequence":"additional","affiliation":[{"name":"Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Cheeloo Medical College, Shandong University, Jinan, Shandong 250012, China"},{"name":"Key Laboratory of Infection and Immunity of Shandong Province, Shandong University, Jinan, Shandong 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Liang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Cheeloo Medical College, Shandong University, Jinan, Shandong 250012, China"},{"name":"Key Laboratory of Infection and Immunity of Shandong Province, Shandong University, Jinan, Shandong 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifeng","family":"Sun","sequence":"additional","affiliation":[{"name":"Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1018-4336","authenticated-orcid":true,"given":"Jiwei","family":"Cui","sequence":"additional","affiliation":[{"name":"Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8121-4718","authenticated-orcid":true,"given":"Chunhong","family":"Ma","sequence":"additional","affiliation":[{"name":"Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Cheeloo Medical College, Shandong University, Jinan, Shandong 250012, China"},{"name":"Key Laboratory of Infection and Immunity of Shandong Province, Shandong University, Jinan, Shandong 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2022,10,7]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2340"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.37173"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302085"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-020-0648-y"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.04.028"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.01.026"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30637"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2015.42"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2018.04.003"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.03.044"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1038\/nri3446"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2021.1898369"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2020.1825687"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.12.007"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.01.030"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.02.003"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.0c00984"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c01928"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-19-0381"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b01383"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2018.12.003"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201803397"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c03772"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3371"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13193"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c08384"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b02071"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.9b00030"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201805148"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b09858"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201707634"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b20504"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b10302"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.01.017"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.02.035"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17637-z"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1039\/D0CC03734F"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c00706"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.12.016"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12169"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-9-39"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.7150\/thno.35434"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1038\/nm1643"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.13126"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.03.021"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.582292"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1038\/381751a0"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2018.02.031"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.03.021"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2014.91"}],"container-title":["ACS Applied Materials &amp; Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.2c11203","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.2c11203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T21:26:25Z","timestamp":1682544385000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsami.2c11203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,7]]},"references-count":50,"journal-issue":{"issue":"41","published-print":{"date-parts":[[2022,10,19]]}},"alternative-id":["10.1021\/acsami.2c11203"],"URL":"https:\/\/doi.org\/10.1021\/acsami.2c11203","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,7]]}}}