{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T21:20:54Z","timestamp":1775337654817,"version":"3.50.1"},"reference-count":69,"publisher":"American Chemical Society (ACS)","issue":"32","license":[{"start":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T00:00:00Z","timestamp":1659484800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T00:00:00Z","timestamp":1659484800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T00:00:00Z","timestamp":1659484800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2018YFA0209800"],"award-info":[{"award-number":["2018YFA0209800"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008718","name":"Judith Jane Mason and Harold Stannett Williams Memorial Foundation","doi-asserted-by":"publisher","award":["MAS2017F034"],"award-info":[{"award-number":["MAS2017F034"]}],"id":[{"id":"10.13039\/100008718","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1111611"],"award-info":[{"award-number":["APP1111611"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015539","name":"Australian Government","doi-asserted-by":"publisher","award":["69172018"],"award-info":[{"award-number":["69172018"]}],"id":[{"id":"10.13039\/100015539","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008436","name":"National Foundation for Medical Research and Innovation","doi-asserted-by":"publisher","award":["MAS2017F034"],"award-info":[{"award-number":["MAS2017F034"]}],"id":[{"id":"10.13039\/100008436","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31800841"],"award-info":[{"award-number":["31800841"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1604177"],"award-info":[{"award-number":["U1604177"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Central Committee of the Communist Party of China"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Appl. Mater. Interfaces"],"published-print":{"date-parts":[[2022,8,17]]},"DOI":"10.1021\/acsami.2c12076","type":"journal-article","created":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T21:09:15Z","timestamp":1659560955000},"page":"36487-36502","source":"Crossref","is-referenced-by-count":20,"title":["Arsenic Prodrug-Mediated Tumor Microenvironment Modulation Platform for Synergetic Glioblastoma Therapy"],"prefix":"10.1021","volume":"14","author":[{"given":"Jiliang","family":"Yan","sequence":"first","affiliation":[{"name":"Henan-Macquarie University Joint Centre for Biomedical Innovation, School of Life Sciences, Henan University, Kaifeng, Henan 475004, China"},{"name":"Henan Key Laboratory of Brain Targeted Bio-nanomedicine, School of Life Sciences and School of Pharmacy, Henan University, Kaifeng 475004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2083-083X","authenticated-orcid":true,"given":"Sumaira","family":"Hanif","sequence":"additional","affiliation":[{"name":"Henan-Macquarie University Joint Centre for Biomedical Innovation, School of Life Sciences, Henan University, Kaifeng, Henan 475004, China"},{"name":"Henan Key Laboratory of Brain Targeted Bio-nanomedicine, School of Life Sciences and School of Pharmacy, Henan University, Kaifeng 475004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongya","family":"Zhang","sequence":"additional","affiliation":[{"name":"Henan-Macquarie University Joint Centre for Biomedical Innovation, School of Life Sciences, Henan University, Kaifeng, Henan 475004, China"},{"name":"Henan Key Laboratory of Brain Targeted Bio-nanomedicine, School of Life Sciences and School of Pharmacy, Henan University, Kaifeng 475004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9995-6912","authenticated-orcid":true,"given":"Muhammad","family":"Ismail","sequence":"additional","affiliation":[{"name":"Henan-Macquarie University Joint Centre for Biomedical Innovation, School of Life Sciences, Henan University, Kaifeng, Henan 475004, China"},{"name":"Henan Key Laboratory of Brain Targeted Bio-nanomedicine, School of Life Sciences and School of Pharmacy, Henan University, Kaifeng 475004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Henan-Macquarie University Joint Centre for Biomedical Innovation, School of Life Sciences, Henan University, Kaifeng, Henan 475004, China"},{"name":"Henan Key Laboratory of Brain Targeted Bio-nanomedicine, School of Life Sciences and School of Pharmacy, Henan University, Kaifeng 475004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6498-7284","authenticated-orcid":true,"given":"Qianjin","family":"Li","sequence":"additional","affiliation":[{"name":"School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing 210023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingyang","family":"Shi","sequence":"additional","affiliation":[{"name":"Henan-Macquarie University Joint Centre for Biomedical Innovation, School of Life Sciences, Henan University, Kaifeng, Henan 475004, China"},{"name":"Henan Key Laboratory of Brain Targeted Bio-nanomedicine, School of Life Sciences and School of Pharmacy, Henan University, Kaifeng 475004, China"},{"name":"Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2109, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5960-0279","authenticated-orcid":true,"given":"Pir","family":"Muhammad","sequence":"additional","affiliation":[{"name":"Henan-Macquarie University Joint Centre for Biomedical Innovation, School of Life Sciences, Henan University, Kaifeng, Henan 475004, China"},{"name":"Henan Key Laboratory of Brain Targeted Bio-nanomedicine, School of Life Sciences and School of Pharmacy, Henan University, Kaifeng 475004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haigang","family":"Wu","sequence":"additional","affiliation":[{"name":"Henan-Macquarie University Joint Centre for Biomedical Innovation, School of Life Sciences, Henan University, Kaifeng, Henan 475004, China"},{"name":"Henan Key Laboratory of Brain Targeted Bio-nanomedicine, School of Life Sciences and School of Pharmacy, Henan University, Kaifeng 475004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2022,8,3]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2014.11.014"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1039\/C8MH00908B"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.1c02078"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1039\/d1sc03516a"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-0230-3"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2256"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00626"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/nri3423"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.10.001"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1416"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1002\/EXP.20210238"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2020.06.001"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201901211"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121110"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21613"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.73.0119"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-016-1497-x"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.03.036"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1002\/anbr.202100008"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.318"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/now258"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2022.101530"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-020-0429-z"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1002\/EXP.20210274"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1039\/c9cs00648f"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1039\/c7cs00594f"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121608"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000760"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30295-X"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2010.06.003"},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1038\/s41467-018-05402-2","volume":"9","author":"Kozono S.","year":"2018","journal-title":"Nat. Commun."},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.5836"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2015.2826"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0128288"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.02.013"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.12.015"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-1812"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.222"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2017.12.041"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1177\/15330338211041454"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202102054"},{"key":"ref42\/cit42","first-page":"1","volume-title":"Encyclopedia of Analytical Chemistry","author":"Liu Z.","year":"2022"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1039\/C5CS00013K"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.7b00179"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2019.111733"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.5b04625"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2017.09.044"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1039\/c9nr09152a"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.101281"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b08714"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b01063"},{"key":"ref52\/cit52","first-page":"231","volume-title":"Aqua Nanotechnology","author":"Luan H.","year":"2021"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1002\/fuce.202000175"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1039\/d0cs01175d"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21436-5"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b00628"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1186\/s11658-020-00236-7"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.6b01378"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.9b00893"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2019.02.058"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202101660"},{"key":"ref62\/cit62","first-page":"3643","volume":"8","author":"Dalton W. S.","year":"2002","journal-title":"Clin. Cancer Res."},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S109695"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202101015"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4002"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2017.231"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2021.05.009"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2020.1783119"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1038\/nri3495"}],"container-title":["ACS Applied Materials & Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.2c12076","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.2c12076","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T11:57:35Z","timestamp":1682423855000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsami.2c12076"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,3]]},"references-count":69,"journal-issue":{"issue":"32","published-print":{"date-parts":[[2022,8,17]]}},"alternative-id":["10.1021\/acsami.2c12076"],"URL":"https:\/\/doi.org\/10.1021\/acsami.2c12076","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,3]]}}}