{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:56:59Z","timestamp":1787000219571,"version":"build-2736575974"},"reference-count":26,"publisher":"American Chemical Society (ACS)","issue":"47","license":[{"start":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T00:00:00Z","timestamp":1699920000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T00:00:00Z","timestamp":1699920000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T00:00:00Z","timestamp":1699920000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100013494","name":"West Light Foundation, Chinese Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013494","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016692","name":"Key Research and Development Program of Ningxia","doi-asserted-by":"publisher","award":["2021BEG02039"],"award-info":[{"award-number":["2021BEG02039"]}],"id":[{"id":"10.13039\/100016692","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004772","name":"Natural Science Foundation of Ningxia Province","doi-asserted-by":"publisher","award":["2022AAC02035"],"award-info":[{"award-number":["2022AAC02035"]}],"id":[{"id":"10.13039\/501100004772","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015811","name":"Science and Technology Department of Ningxia Province","doi-asserted-by":"publisher","award":["2022GKLRLX011"],"award-info":[{"award-number":["2022GKLRLX011"]}],"id":[{"id":"10.13039\/100015811","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260699"],"award-info":[{"award-number":["82260699"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Appl. Mater. Interfaces"],"published-print":{"date-parts":[[2023,11,29]]},"DOI":"10.1021\/acsami.3c11394","type":"journal-article","created":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T13:00:50Z","timestamp":1699966850000},"page":"54898-54914","source":"Crossref","is-referenced-by-count":8,"title":["Tumor Microenvironment Sequential Drug\/Gene Delivery Nanosystem for Realizing Multistage Boosting of Cancer\u2013Immunity Cycle on Cancer Immunotherapy"],"prefix":"10.1021","volume":"15","author":[{"given":"Yongjing","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmacy, Ningxia Medical University, No. 1160, Shengli Street, Yinchuan 750004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmacy, Ningxia Medical University, No. 1160, Shengli Street, Yinchuan 750004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiangwei","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmacy, Ningxia Medical University, No. 1160, Shengli Street, Yinchuan 750004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmacy, Ningxia Medical University, No. 1160, Shengli Street, Yinchuan 750004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmacy, Ningxia Medical University, No. 1160, Shengli Street, Yinchuan 750004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juntao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmacy, Ningxia Medical University, No. 1160, Shengli Street, Yinchuan 750004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"An","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmacy, Ningxia Medical University, No. 1160, Shengli Street, Yinchuan 750004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Bi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmacy, Ningxia Medical University, No. 1160, Shengli Street, Yinchuan 750004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1104-284X","authenticated-orcid":true,"given":"Yanhua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmacy, Ningxia Medical University, No. 1160, Shengli Street, Yinchuan 750004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2023,11,14]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-018-0006-z"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201804882"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.10.011"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.06.041"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121528"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.21037\/jgo.2018.05.16"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abc7828"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201803322"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120604"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.7150\/thno.56936"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120638"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2023.02.034"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.107"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2366"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0215950"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.3390\/cancers10120498"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.7.3725"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-016-2687-0"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.12.053"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202006189"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b02149"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-0635"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.0c00048"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2015.1074374"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c14405"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.04.034"}],"container-title":["ACS Applied Materials &amp; Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.3c11394","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.3c11394","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T06:29:17Z","timestamp":1701239357000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsami.3c11394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,14]]},"references-count":26,"journal-issue":{"issue":"47","published-print":{"date-parts":[[2023,11,29]]}},"alternative-id":["10.1021\/acsami.3c11394"],"URL":"https:\/\/doi.org\/10.1021\/acsami.3c11394","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,14]]}}}