{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:56:39Z","timestamp":1785416199269,"version":"3.56.0"},"reference-count":54,"publisher":"American Chemical Society (ACS)","issue":"6","license":[{"start":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:00:00Z","timestamp":1706832000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:00:00Z","timestamp":1706832000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:00:00Z","timestamp":1706832000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100018534","name":"Medical Innovation Project of Fujian Province","doi-asserted-by":"publisher","award":["2021CXA030"],"award-info":[{"award-number":["2021CXA030"]}],"id":[{"id":"10.13039\/501100018534","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Scientific Foundation of Fujian Province","award":["2022J011282"],"award-info":[{"award-number":["2022J011282"]}]},{"name":"Major Scientific Research Program for Young and Middle-aged Health Professionals of Fujian Province","award":["2021ZQNZD009"],"award-info":[{"award-number":["2021ZQNZD009"]}]},{"name":"Scientific Foundation of Fuzhou Municipal Health Commission","award":["2022-S-rc1"],"award-info":[{"award-number":["2022-S-rc1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Appl. Mater. Interfaces"],"published-print":{"date-parts":[[2024,2,14]]},"DOI":"10.1021\/acsami.3c18140","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T17:09:35Z","timestamp":1706893775000},"page":"6894-6907","source":"Crossref","is-referenced-by-count":14,"title":["Biomimetic Responsive Nanoconverters with Immune Checkpoint Blockade Plus Antiangiogenesis for Advanced Hepatocellular Carcinoma Treatment"],"prefix":"10.1021","volume":"16","author":[{"given":"Yuting","family":"Zhang","sequence":"first","affiliation":[{"name":"Innovation Center for Cancer Research, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, P. R. China"},{"name":"The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aoxue","family":"Zhong","sequence":"additional","affiliation":[{"name":"The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Min","sequence":"additional","affiliation":[{"name":"Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibin","family":"Tu","sequence":"additional","affiliation":[{"name":"The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanbing","family":"Cao","sequence":"additional","affiliation":[{"name":"The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghao","family":"Fu","sequence":"additional","affiliation":[{"name":"The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghao","family":"Li","sequence":"additional","affiliation":[{"name":"The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3096-4981","authenticated-orcid":true,"given":"Xiaolong","family":"Liu","sequence":"additional","affiliation":[{"name":"The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Yang","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Advanced Technology for Cancer Screening and Early Diagnosis, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmin","family":"Wang","sequence":"additional","affiliation":[{"name":"Innovation Center for Cancer Research, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, P. R. China"},{"name":"Fujian Key Laboratory of Advanced Technology for Cancer Screening and Early Diagnosis, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingfeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Innovation Center for Cancer Research, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, P. R. China"},{"name":"The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, P. R. China"},{"name":"Fujian Key Laboratory of Advanced Technology for Cancer Screening and Early Diagnosis, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8326-4076","authenticated-orcid":true,"given":"Ming","family":"Wu","sequence":"additional","affiliation":[{"name":"The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,2,2]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-00240-3"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.18"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1713263"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31327"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30207-1"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31046-2"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.01307"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.36.4_suppl.209"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1915745"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2021.39.3_suppl.267"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-020-00652-z"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.36.5_suppl.207"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2016.04.011"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/nbt0905-1073"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2021.39.15_suppl.e16120"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2022.40.16_suppl.e16147"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.958869"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15030854"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2022.05.032"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.34133\/bmef.0016"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.01.033"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2014.05.006"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.101341"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2023.04.011"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201707598"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201900251"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2297"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201606209"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201900605"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b03788"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202004397"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1038\/nature15373"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2022.11.001"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201900772"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201900795"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2022.11.003"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2010.02.024"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.125742"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.7150\/thno.18607"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.116093"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202000075"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1021\/ja1069932"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c03279"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2018.08.038"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.09.016"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-01-012369"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS01021H"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1126\/science.1104819"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.01.036"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25538"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42155-z"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-018-0058-y"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-021-03701-8"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1007\/s11051-017-3913-8"}],"container-title":["ACS Applied Materials &amp; Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.3c18140","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.3c18140","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T11:03:18Z","timestamp":1707908598000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsami.3c18140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,2]]},"references-count":54,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,2,14]]}},"alternative-id":["10.1021\/acsami.3c18140"],"URL":"https:\/\/doi.org\/10.1021\/acsami.3c18140","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,2]]}}}