{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:25:23Z","timestamp":1792009523883,"version":"4.4.0"},"reference-count":53,"publisher":"American Chemical Society (ACS)","issue":"34","license":[{"start":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T00:00:00Z","timestamp":1723766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006477","name":"National Taiwan University","doi-asserted-by":"publisher","award":["112HT549002"],"award-info":[{"award-number":["112HT549002"]}],"id":[{"id":"10.13039\/501100006477","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Reliance Biosciences Inc.","award":["2022-03-001"],"award-info":[{"award-number":["2022-03-001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Appl. Mater. Interfaces"],"published-print":{"date-parts":[[2024,8,28]]},"DOI":"10.1021\/acsami.4c03869","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T04:44:49Z","timestamp":1723783489000},"page":"44386-44398","source":"Crossref","is-referenced-by-count":55,"title":["Improving the Purity of Extracellular Vesicles by Removal of Lipoproteins from Size Exclusion Chromatography- and Ultracentrifugation-Processed Samples Using Glycosaminoglycan-Functionalized Magnetic Beads"],"prefix":"10.1021","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5736-4195","authenticated-orcid":true,"given":"Cheng-Yu","family":"Chou","sequence":"first","affiliation":[{"name":"Institute of Applied Mechanics, National Taiwan University, 1 Roosevelt Road, Sec. 4, Taipei 106319, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Chieh","family":"Chiang","sequence":"additional","affiliation":[{"name":"Reliance Biosciences, Inc., New Taipei City 231023, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Chi","family":"Li","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei 106319, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jheng-Wun","family":"Chang","sequence":"additional","affiliation":[{"name":"Institute of Applied Mechanics, National Taiwan University, 1 Roosevelt Road, Sec. 4, Taipei 106319, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Han","family":"Lu","sequence":"additional","affiliation":[{"name":"Institute of Applied Mechanics, National Taiwan University, 1 Roosevelt Road, Sec. 4, Taipei 106319, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Fan","family":"Hsu","sequence":"additional","affiliation":[{"name":"Institute of Applied Mechanics, National Taiwan University, 1 Roosevelt Road, Sec. 4, Taipei 106319, Taiwan"},{"name":"Reliance Biosciences, Inc., New Taipei City 231023, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Chun","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital, Taipei 100225, Taiwan"},{"name":"Health Management Center, National Taiwan University Hospital, Taipei 100225, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Lung","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Neurology, New Taipei Municipal TuCheng Hospital, New Taipei City 236017, Taiwan"},{"name":"Department of Neurology, Chang Gung Memorial Hospital Linkou Medical Center and College of Medicine, Neuroscience Research Center, Chang-Gung University, Linkou, Taoyuan 33302, Taiwan"},{"name":"Graduate Institute of Mind, Brain, & Consciousness, Taipei Medical University, Taipei 110301, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Shiang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital, Taipei 100225, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1633-4019","authenticated-orcid":true,"given":"Andrew M.","family":"Wo","sequence":"additional","affiliation":[{"name":"Institute of Applied Mechanics, National Taiwan University, 1 Roosevelt Road, Sec. 4, Taipei 106319, Taiwan"},{"name":"Reliance Biosciences, Inc., New Taipei City 231023, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,8,16]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201901779"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.02.029"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau6977"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c04337"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2018.11.006"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1002\/adbi.201900310"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-018-2773-4"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1021\/nn103098m"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2021.113872"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2018.11.006"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1521230113"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.3402\/jev.v4.27031"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-019-0236-5"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12145"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311767"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.202200364"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1080\/15476286.2018.1564465"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.1c05378"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12110"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-57497-7"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1080\/20013078.2017.1308779"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-47750-z"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c21150"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c07193"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b02014"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c04829"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c01340"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.7150\/thno.69094"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.9b05675"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2016.07.022"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/375390"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.8b00225"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c00922"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12128"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12122"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-10646-x"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01479"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.86394"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202100242R"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1023\/A:1021155518464"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.3402\/jev.v3.23430"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11182-0"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1080\/20013078.2018.1535750"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1002\/jex2.66"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2021.122604"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12140"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1038\/srep24316"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.3390\/biom13020278"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1007\/s10616-015-9913-6"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1111\/his.13194"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1111\/cns.13846"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00361-6"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1080\/20013078.2020.1791450"}],"container-title":["ACS Applied Materials & Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.4c03869","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.4c03869","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T06:22:32Z","timestamp":1724826152000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsami.4c03869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,16]]},"references-count":53,"journal-issue":{"issue":"34","published-print":{"date-parts":[[2024,8,28]]}},"alternative-id":["10.1021\/acsami.4c03869"],"URL":"https:\/\/doi.org\/10.1021\/acsami.4c03869","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,16]]}}}