{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T15:33:47Z","timestamp":1792424027928,"version":"4.5.0"},"reference-count":49,"publisher":"American Chemical Society (ACS)","issue":"3","license":[{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100013058","name":"Jiangsu Provincial Key Research and Development Program","doi-asserted-by":"publisher","award":["BE2022826"],"award-info":[{"award-number":["BE2022826"]}],"id":[{"id":"10.13039\/501100013058","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Appl. Mater. Interfaces"],"published-print":{"date-parts":[[2025,1,22]]},"DOI":"10.1021\/acsami.4c14203","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T04:42:17Z","timestamp":1736743337000},"page":"4416-4425","source":"Crossref","is-referenced-by-count":21,"title":["Ionizable Cholesterol Analogs as the Fifth Component of Lipid Nanoparticles for Selective Targeting Delivery of mRNA"],"prefix":"10.1021","volume":"17","author":[{"given":"Chao","family":"Liu","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhao","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenliang","family":"Xue","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyu","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhong","family":"Luo","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7930-7501","authenticated-orcid":true,"given":"Xinsong","family":"Li","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,1,13]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-020-0737-y"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-021-00358-0"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.7150\/jca.63991"},{"key":"ref4\/cit4a","doi-asserted-by":"publisher","DOI":"10.1038\/nature21428"},{"key":"ref4\/cit4b","doi-asserted-by":"publisher","unstructured":"Brazzoli, M.; Magini, D.; Bonci, A.; Buccato, S.; Giovani, C.; Kratzer, R.; Zurli, V.; Mangiavacchi, S.; Casini, D.; Brito, L. M. J.; De Gregorio, E.; Mason, P. W.; Ulmer, J. B.; Geall, A. J.; Bertholet, S.Induction of broad-based immunity and protective efficacy by self-amplifying mRNA vaccines encoding influenza virus hemagglutinin.\n                      J. Virol.\n                      2016, 90 (1), 332\u201334410.1128\/jvi.01786-15.","DOI":"10.1128\/jvi.01786-15"},{"key":"ref4\/cit4c","doi-asserted-by":"publisher","unstructured":"Jackson, L. A.; Anderson, E. J.; Rouphael, N. G.; Roberts, P. C.; Makhene, M.; Coler, R. N.; McCullough, M. P.; Chappell, J. D.; Denison, M. R.; Stevens, L. J.An mRNA vaccine against SARS-CoV-2\u2500preliminary report.\n                      N. Engl. J. Med.\n                      2020, 383 (20), 1920\u2013193110.1056\/NEJMoa2022483.","DOI":"10.1056\/NEJMoa2022483"},{"key":"ref5\/cit5a","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2010.08.012"},{"key":"ref5\/cit5b","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2022.122565"},{"key":"ref6\/cit6a","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.9b04246"},{"key":"ref6\/cit6b","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2019.05.012"},{"key":"ref6\/cit6c","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.2c00463"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1126\/science.abm0594"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.add4623"},{"key":"ref9\/cit9a","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1716153"},{"key":"ref9\/cit9b","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202303713"},{"key":"ref10\/cit10a","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2017.243"},{"key":"ref10\/cit10b","doi-asserted-by":"publisher","unstructured":"Pardi, N.; Hogan, M. J.; Weissman, D.Recent advances in mRNA vaccine technology.\n                      Curr. Opin. Immunol.\n                      2020, 65, 14\u20132010.1016\/j.coi.2020.01.008.","DOI":"10.1016\/j.coi.2020.01.008"},{"key":"ref10\/cit10c","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201805097"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201805740"},{"key":"ref12\/cit12a","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202304378"},{"key":"ref12\/cit12b","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202303568"},{"key":"ref13\/cit13a","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.10.015"},{"key":"ref13\/cit13b","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121339"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.01775-23"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202204636"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11050640"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.03.046"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202013927"},{"key":"ref19\/cit19a","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202008082"},{"key":"ref19\/cit19b","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32281-5"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c02706"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-020-0669-6"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2109256118"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202312026"},{"key":"ref24\/cit24a","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27493-0"},{"key":"ref24\/cit24b","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b03640"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-023-01138-9"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-14527-2"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-50093-7"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.1c00544"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c00244"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-021-02441-2"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c00451"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.03.016"},{"key":"ref33\/cit33","unstructured":"<monopoli-et-al-2011-physical-chemical-aspects-of-protein-corona-relevance-to-in-vitro-and-in-vivo-biological-impacts-si.pdf>"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c02704"},{"key":"ref35\/cit35a","doi-asserted-by":"publisher","DOI":"10.1021\/ja107583h"},{"key":"ref35\/cit35b","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2109256118"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202105832"}],"container-title":["ACS Applied Materials &amp; Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.4c14203","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.4c14203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T04:13:33Z","timestamp":1737519213000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsami.4c14203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,13]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,1,22]]}},"alternative-id":["10.1021\/acsami.4c14203"],"URL":"https:\/\/doi.org\/10.1021\/acsami.4c14203","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,13]]}}}