{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:15:14Z","timestamp":1791818114548,"version":"4.3.4"},"reference-count":59,"publisher":"American Chemical Society (ACS)","issue":"43","license":[{"start":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T00:00:00Z","timestamp":1729036800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T00:00:00Z","timestamp":1729036800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T00:00:00Z","timestamp":1729036800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100004703","name":"Guangxi University for Nationalities","doi-asserted-by":"publisher","award":["2022KJQD13"],"award-info":[{"award-number":["2022KJQD13"]}],"id":[{"id":"10.13039\/501100004703","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004703","name":"Guangxi University for Nationalities","doi-asserted-by":"publisher","award":["2023MDSY013"],"award-info":[{"award-number":["2023MDSY013"]}],"id":[{"id":"10.13039\/501100004703","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011827","name":"Guangxi Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011827","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017691","name":"Guangxi Key Research and Development Program","doi-asserted-by":"publisher","award":["AB23026137"],"award-info":[{"award-number":["AB23026137"]}],"id":[{"id":"10.13039\/501100017691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018571","name":"Specific Research Project of Guangxi for Research Bases and Talents","doi-asserted-by":"publisher","award":["AD23026052"],"award-info":[{"award-number":["AD23026052"]}],"id":[{"id":"10.13039\/501100018571","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012547","name":"Natural Science Foundation of Guangxi Zhuang Autonomous Region","doi-asserted-by":"publisher","award":["2023GXNSFBA026191"],"award-info":[{"award-number":["2023GXNSFBA026191"]}],"id":[{"id":"10.13039\/100012547","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017596","name":"Natural Science Basic Research Program of Shaanxi Province","doi-asserted-by":"publisher","award":["2023-JC-QN-0378"],"award-info":[{"award-number":["2023-JC-QN-0378"]}],"id":[{"id":"10.13039\/501100017596","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82360367"],"award-info":[{"award-number":["82360367"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82360793"],"award-info":[{"award-number":["82360793"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012543","name":"Youth Science Foundation of Guangxi Medical University","doi-asserted-by":"publisher","award":["GXMUYSF202204"],"award-info":[{"award-number":["GXMUYSF202204"]}],"id":[{"id":"10.13039\/501100012543","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guangxi Science and technology project","award":["FANGKE ZY20221502"],"award-info":[{"award-number":["FANGKE ZY20221502"]}]},{"name":"Guangxi Province University Young and Middle-aged Teachers Research Basic Research Capacity Improvement Project","award":["2023KY0144"],"award-info":[{"award-number":["2023KY0144"]}]},{"name":"Guangxi Province University Young and Middle-aged Teachers Research Basic Research Capacity Improvement Project","award":["2023KY0179"],"award-info":[{"award-number":["2023KY0179"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Appl. Mater. Interfaces"],"published-print":{"date-parts":[[2024,10,30]]},"DOI":"10.1021\/acsami.4c15320","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T12:45:18Z","timestamp":1729082718000},"page":"58489-58505","source":"Crossref","is-referenced-by-count":24,"title":["Precision Delivery of Binary Cooperative Nanodrugs Self-Assembled by Berberine Glycyrrhetinic Acid Salts for Hepatocellular Carcinoma Treatment"],"prefix":"10.1021","volume":"16","author":[{"given":"Yang","family":"Xiao","sequence":"first","affiliation":[{"name":"Guangxi Key Laboratory of Bioactive Molecules Research and Evaluation, Pharmaceutical College, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, P. R. China"},{"name":"Key Laboratory of Longevity and Aging-related Diseases of Chinese Ministry of Education, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alu","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Bioactive Molecules Research and Evaluation, Pharmaceutical College, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Fan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Chemistry and Engineering of Forest Products, State Ethnic Affairs Commission, Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products, School of Chemistry and Chemical Engineering","place":["Nanning, P. R. China"]},{"name":"Guangxi Minzu University","place":["Nanning, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Qin","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Bioactive Molecules Research and Evaluation, Pharmaceutical College, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Li","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Bioactive Molecules Research and Evaluation, Pharmaceutical College, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixin","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Bioactive Molecules Research and Evaluation, Pharmaceutical College, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingyun","family":"Yuan","sequence":"additional","affiliation":[{"name":"Shaanxi Key Laboratory of Biomedical Metal Materials","place":["Xi\u2019an, P. R. China"]},{"name":"Northwest Institute for Nonferrous Metal Research","place":["Xi\u2019an, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejing","family":"Huang","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Bioactive Molecules Research and Evaluation, Pharmaceutical College, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Hao","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Bioactive Molecules Research and Evaluation, Pharmaceutical College, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, P. R. China"},{"name":"Key Laboratory of Longevity and Aging-related Diseases of Chinese Ministry of Education, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5985-8533","authenticated-orcid":true,"given":"Hongyan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmacy","place":["Nantong, P. R. China"]},{"name":"Nantong University","place":["Nantong, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuju","family":"Huang","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Bioactive Molecules Research and Evaluation, Pharmaceutical College, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Guo","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Bioactive Molecules Research and Evaluation, Pharmaceutical College, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, P. R. China"},{"name":"Key Laboratory of Longevity and Aging-related Diseases of Chinese Ministry of Education, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7445-5188","authenticated-orcid":true,"given":"Ronghua","family":"Jin","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Bioactive Molecules Research and Evaluation, Pharmaceutical College, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,10,16]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.5582\/bst.2022.01061"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2019-IO-S1-s01"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202307242"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-00240-3"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00264-x"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2018.10.040"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2013.07.030"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.9b01285"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.7150\/thno.18290"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2016.125"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109794"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.livres.2022.08.003"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2020.06.014"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2012.07.018"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154217"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.111951"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/s42004-023-00821-9"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2024.108593"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2014.03.017"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.02.066"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1080\/03602532.2017.1306544"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b17722"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2019.12.014"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c06968"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b01346"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c22900"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S153944"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2018.04.052"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.02.042"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.5b00677"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2020.124915"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2018.09.012"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201801961"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.8b00427"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2021.03.084"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1039\/C9BM01992H"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmt.2020.100883"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/acsanm.7b00152"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.10.016"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmt.2024.102102"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.891829"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1038\/s44222-023-00138-1"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28248038"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109002"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1039\/C8CC05175E"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2017.08.064"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jced.8b00258"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.9b01007"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202301183"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-02449-y"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1186\/s13020-021-00507-1"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.07.006"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2010.01.033"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1039\/D1FO02783B"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19020327"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.122409"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2018.11.035"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3629"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2013.69"}],"container-title":["ACS Applied Materials & Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.4c15320","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.4c15320","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T09:10:18Z","timestamp":1740474618000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsami.4c15320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,16]]},"references-count":59,"journal-issue":{"issue":"43","published-print":{"date-parts":[[2024,10,30]]}},"alternative-id":["10.1021\/acsami.4c15320"],"URL":"https:\/\/doi.org\/10.1021\/acsami.4c15320","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,16]]}}}