{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T05:35:02Z","timestamp":1793424902636,"version":"4.5.0"},"reference-count":70,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T00:00:00Z","timestamp":1740960000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T00:00:00Z","timestamp":1740960000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T00:00:00Z","timestamp":1740960000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS125016"],"award-info":[{"award-number":["R01NS125016"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000146","name":"Division of Chemical, Bioengineering, Environmental, and Transport Systems","doi-asserted-by":"publisher","award":["CBET-1917618"],"award-info":[{"award-number":["CBET-1917618"]}],"id":[{"id":"10.13039\/100000146","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Appl. Mater. Interfaces"],"published-print":{"date-parts":[[2025,3,12]]},"DOI":"10.1021\/acsami.4c22692","type":"journal-article","created":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T20:59:16Z","timestamp":1741035556000},"page":"15145-15162","source":"Crossref","is-referenced-by-count":18,"title":["Engineering Extracellular Vesicles Secreted by Human Brain Organoids with Different Regional Identity"],"prefix":"10.1021","volume":"17","author":[{"given":"Chang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering","place":["Tallahassee, United States"]},{"name":"Florida State University","place":["Tallahassee, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingchi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering","place":["Tallahassee, United States"]},{"name":"Florida State University","place":["Tallahassee, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justice","family":"Ene","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering","place":["Tallahassee, United States"]},{"name":"Florida State University","place":["Tallahassee, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Esmonde","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering","place":["Tallahassee, United States"]},{"name":"Florida State University","place":["Tallahassee, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahisa","family":"Kanekiyo","sequence":"additional","affiliation":[{"name":"Mayo Clinic","place":["Jacksonville, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changchun","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Industrial and Manufacturing Engineering, FAMU-FSU College of Engineering","place":["Tallahassee, United States"]},{"name":"Florida State University","place":["Tallahassee, United States"]},{"name":"High Performance Materials Institute","place":["Tallahassee, United States"]},{"name":"Florida State University","place":["Tallahassee, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8228-7487","authenticated-orcid":true,"given":"Li","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering","place":["Tallahassee, United States"]},{"name":"Florida State University","place":["Tallahassee, United States"]},{"name":"Department of Biomedical Sciences, College of Medicine","place":["Tallahassee, United States"]},{"name":"Florida State University","place":["Tallahassee, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5938-8519","authenticated-orcid":true,"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering","place":["Tallahassee, United States"]},{"name":"Florida State University","place":["Tallahassee, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,3,3]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1007\/s13365-023-01133-3"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-020-00643-3"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0106973"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3312"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1111\/aor.13880"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.crmeth.2022.100337"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1242\/dev.166074"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-00730-3"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2022.102536"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.12.051"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2021.06.006"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1242\/dev.170910"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2020.0135"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-16970-1"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1080\/20013078.2020.1809064"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1571-8"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.7150\/thno.56367"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-021-00791-x"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.04.017"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000621"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-023-00711-y"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.3390\/cells9071618"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-021-01255-2"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1002\/bit.27606"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201800948"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10123060"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-022-00460-3"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12235"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.07.004"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1002\/jex2.70002"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1600502"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.11.026"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aay4361"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-023-00551-3"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-39861-4"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adf9016"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1038\/s41536-022-00208-9"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202301112"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2016.08.041"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2017.0153"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1002\/jex2.133"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2016.0400"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2017.0423"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-47444-6"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.bej.2022.108711"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.09.020"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tec.2020.0243"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7253-1_25"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2018.05.022"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.10.003"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.3390\/app12157472"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1159\/000522575"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2013.06.004"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1021\/la4032199"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.05.107"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.7b00950"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001928"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2020.01.030"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.4161\/org.4.2.5852"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2018.07.021"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2012.03.010"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-018-0895-0"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.32.20121"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-1094fje"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2013.05.001"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(00)76295-3"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(00)76294-1"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12024"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1177\/0885328217698062"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2022.0091"}],"container-title":["ACS Applied Materials & Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.4c22692","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.4c22692","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T10:31:06Z","timestamp":1741775466000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsami.4c22692"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,3]]},"references-count":70,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,3,12]]}},"alternative-id":["10.1021\/acsami.4c22692"],"URL":"https:\/\/doi.org\/10.1021\/acsami.4c22692","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,3]]}}}