{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:44:03Z","timestamp":1792784643743,"version":"4.5.0"},"reference-count":39,"publisher":"American Chemical Society (ACS)","issue":"29","license":[{"start":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T00:00:00Z","timestamp":1751932800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007956","name":"Nanjing University of Chinese Medicine","doi-asserted-by":"publisher","award":["ZYXYL2024-012"],"award-info":[{"award-number":["ZYXYL2024-012"]}],"id":[{"id":"10.13039\/501100007956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2308200"],"award-info":[{"award-number":["2023YFC2308200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20220472"],"award-info":[{"award-number":["BK20220472"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010040","name":"Taishan Scholar Project of Shandong Province","doi-asserted-by":"publisher","award":["tstp20231239"],"award-info":[{"award-number":["tstp20231239"]}],"id":[{"id":"10.13039\/501100010040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002949","name":"Government of Jiangsu Province","doi-asserted-by":"publisher","award":["021093002902"],"award-info":[{"award-number":["021093002902"]}],"id":[{"id":"10.13039\/501100002949","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204292"],"award-info":[{"award-number":["82204292"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Xuzhou Municipal Health Commission","award":["XWKYHT20240002"],"award-info":[{"award-number":["XWKYHT20240002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The ideal treatment for myocardial infarction should address the critical issues of oxygen supply improvement in the infarcted area and prevention of myocardial cell death. Myocardial necrosis is a reversible process, but the challenge lies in mitigating the irreversible pyroptosis of cardiomyocytes, which significantly impedes the recovery of cardiac function. To tackle these complexities, here we have developed MnO2@INN@Alb (MIA) nanoparticles. MIA nanoparticles possess the unique ability to generate oxygen and release glibenclamide (INN) in response to the acidic and H2O2-rich environments present in the infarcted region. MIA plays a dual role by inhibiting the pyroptosis process of cardiomyocytes through the suppression of NLRP3 and by providing vital oxygen to alleviate hypoxia. The results shows that MIA can effectively reverse cardiomyocyte hypoxia, reduce infarct fibrosis, and aid in the reconstruction of myocardial vessels. Moreover, MIA demonstrates high biocompatibility, making it a promising avenue for the future of myocardial infarction improvement. We anticipate that MIA can pave the way for novel solutions and research paradigms in the field.<\/jats:p>","DOI":"10.1021\/acsami.5c01964","type":"journal-article","created":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T11:26:36Z","timestamp":1751973996000},"page":"41626-41636","source":"Crossref","is-referenced-by-count":4,"title":["Ameliorating Myocardial\nInfarction by Concurrent Pyroptosis\nSuppression and On-Demand Oxygen Production via Functionalized Nanocarrier"],"prefix":"10.1021","volume":"17","author":[{"given":"Wenwu","family":"Zhu","sequence":"first","affiliation":[{"name":"Xuzhou Central Hospital , , ,","place":["Xuzhou, China, 221000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Lu","sequence":"additional","affiliation":[{"name":"Xuzhou Central Hospital , , ,","place":["Xuzhou, China, 221000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zong","sequence":"additional","affiliation":[{"name":"Xuzhou Central Hospital , , ,","place":["Xuzhou, China, 221000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Chen","sequence":"additional","affiliation":[{"name":"Nanjing University of Chinese Medicine , , ,","place":["Nanjing, China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Ma","sequence":"additional","affiliation":[{"name":"The Second AffiliatedHospital of Xuzhou Medical University , ,","place":["Xuzhou, China, 221000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1630-4813","authenticated-orcid":true,"given":"Haoran","family":"Wang","sequence":"additional","affiliation":[{"name":"Nanjing University of Chinese Medicine , , ,","place":["Nanjing, China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2044-3074","authenticated-orcid":true,"given":"Peng","family":"Cao","sequence":"additional","affiliation":[{"name":"Nanjing University of Chinese Medicine , , ,","place":["Nanjing, China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1247-9235","authenticated-orcid":true,"given":"Bing","family":"Han","sequence":"additional","affiliation":[{"name":"Xuzhou Central Hospital , , ,","place":["Xuzhou, China, 221000"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,7,8]]},"reference":[{"issue":"1","key":"2026072521091977000_cit1","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1186\/s12872-023-03231-w","article-title":"The global\nprevalence of myocardial infarction: a systematic review and meta-analysis","volume":"23","author":"Salari","year":"2023","journal-title":"BMC cardiovascular disorders"},{"issue":"1","key":"2026072521091977000_cit2","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1038\/s41392-022-00925-z","article-title":"Signaling pathways and targeted therapy for myocardial\ninfarction","volume":"7","author":"Zhang","year":"2022","journal-title":"Signal transduction and targeted\ntherapy"},{"key":"2026072521091977000_cit3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s44222-025-00293-7","article-title":"Mechanisms and strategies\nfor organ recovery","author":"Andrijevic","year":"2025","journal-title":"Nature Reviews Bioengineering"},{"key":"2026072521091977000_cit4","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.750510","article-title":"Cardiomyocytes cellular\nphenotypes after myocardial\ninfarction","volume":"8","author":"Lodrini","year":"2021","journal-title":"Frontiers in cardiovascular medicine"},{"issue":"2","key":"2026072521091977000_cit5","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.3390\/ijms25021082","article-title":"The role of pro-inflammatory\ncytokines in the pathogenesis\nof cardiovascular disease","volume":"25","author":"Zhang","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"2026072521091977000_cit6","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2023.2298514","article-title":"Multiple delivery\nstrategies of nanocarriers\nfor myocardial ischemia-reperfusion injury: Current strategies and\nfuture prospective","volume":"31","author":"Li","year":"2024","journal-title":"Drug delivery"},{"issue":"1","key":"2026072521091977000_cit7","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1186\/s12967-022-03642-x","article-title":"Omentin1 ameliorates\nmyocardial ischemia-induced heart failure via SIRT3\/FOXO3a-dependent\nmitochondrial dynamical homeostasis and mitophagy","volume":"20","author":"Hu","year":"2022","journal-title":"Journal of translational medicine"},{"key":"2026072521091977000_cit8","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.1085432","article-title":"Oxygen switches: Refueling\nfor cancer\nradiotherapy","volume":"12","author":"Li","year":"2023","journal-title":"Frontiers in Oncology"},{"key":"2026072521091977000_cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120621","article-title":"Light-controlled oxygen production\nand collection for sustainable photodynamic therapy in tumor hypoxia","volume":"269","author":"Wang","year":"2021","journal-title":"Biomaterials"},{"issue":"3","key":"2026072521091977000_cit10","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1097\/HM9.0000000000000129","article-title":"The mechanism and treatment\nstrategies of GSDMD-mediated pyroptosis in myocardial infarction","volume":"4","author":"Li","year":"2024","journal-title":"Acupuncture and Herbal Medicine"},{"issue":"1","key":"2026072521091977000_cit11","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.apsb.2022.08.007","article-title":"Gasdermin D-mediated pyroptosis in\nmyocardial ischemia and reperfusion injury: Cumulative evidence for\nfuture cardioprotective strategies","volume":"13","author":"Yanpiset","year":"2023","journal-title":"Acta Pharmaceutica\nSinica B"},{"issue":"29","key":"2026072521091977000_cit12","doi-asserted-by":"publisher","first-page":"33756","DOI":"10.1021\/acsami.1c03421","article-title":"Engineered biomimetic\nnanoplatform\nprotects the myocardium against ischemia\/reperfusion injury by inhibiting\npyroptosis","volume":"13","author":"Wei","year":"2021","journal-title":"ACS Appl. Mater. 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Drug Discovery"},{"issue":"3","key":"2026072521091977000_cit21","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1097\/HM9.0000000000000109","article-title":"Ferulic acid\nreduces inflammatory\nresponse induced by radiation through Sirt1-NLRP3 pathway","volume":"4","author":"Nie","year":"2024","journal-title":"Acupuncture and Herbal Medicine"},{"issue":"10","key":"2026072521091977000_cit22","doi-asserted-by":"publisher","first-page":"6590","DOI":"10.1007\/s12035-022-02998-x","article-title":"Glibenclamide directly prevents neuroinflammation by targeting SUR1-TRPM4-mediated\nNLRP3 inflammasome activation in microglia","volume":"59","author":"He","year":"2022","journal-title":"Molecular Neurobiology"},{"issue":"1","key":"2026072521091977000_cit23","doi-asserted-by":"publisher","first-page":"37","DOI":"10.2174\/1568026620666191224141617","article-title":"Mechanisms and characteristics\nof sulfonylureas and glinides","volume":"20","author":"Lv","year":"2020","journal-title":"Current topics\nin medicinal chemistry"},{"key":"2026072521091977000_cit24","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.bioactmat.2021.10.028","article-title":"Photosynthetic microorganisms coupled\nphotodynamic therapy for enhanced\nantitumor immune effect","volume":"12","author":"Wang","year":"2022","journal-title":"Bioactive Materials"},{"issue":"2","key":"2026072521091977000_cit25","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202308477","article-title":"A Cardiac-Targeted\nNanozyme Interrupts the Inflammation-Free Radical Cycle in Myocardial\nInfarction","volume":"36","author":"Liu","year":"2024","journal-title":"Adv. Mater."},{"key":"2026072521091977000_cit26","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1016\/j.actbio.2022.10.002","article-title":"A tumor pH-responsive\nautocatalytic nanoreactor as a H2O2 and O2 self-supplying depot for\nenhanced ROS-based chemo\/photodynamic therapy","volume":"154","author":"Liu","year":"2022","journal-title":"Acta Biomaterialia"},{"issue":"6","key":"2026072521091977000_cit27","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1039\/D2NA00530A","article-title":"Functional nano-systems for transdermal drug delivery and skin therapy","volume":"5","author":"Liu","year":"2023","journal-title":"Nanoscale Advances"},{"key":"2026072521091977000_cit28","doi-asserted-by":"publisher","first-page":"5971","DOI":"10.2147\/JIR.S436560","article-title":"Macrophage heterogeneity\nand its impact on myocardial ischemia-reperfusion injury: an integrative\nreview","volume":"16","author":"Xu","year":"2023","journal-title":"Journal of Inflammation Research"},{"issue":"2","key":"2026072521091977000_cit29","doi-asserted-by":"publisher","first-page":"300","DOI":"10.3390\/biology11020300","article-title":"The interplay of hypoxia signaling\non mitochondrial dysfunction and inflammation in cardiovascular diseases\nand cancer: from molecular mechanisms to therapeutic approaches","volume":"11","author":"Bouhamida","year":"2022","journal-title":"Biology"},{"key":"2026072521091977000_cit30","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.738325","article-title":"The role of the VEGF family in coronary heart disease","volume":"8","author":"Zhou","year":"2021","journal-title":"Frontiers in cardiovascular medicine"},{"issue":"1","key":"2026072521091977000_cit31","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1161\/CIRCULATIONAHA.120.050635","article-title":"VEGF-B promotes endocardium-derived\ncoronary vessel\ndevelopment and cardiac regeneration","volume":"143","author":"Rasanen","year":"2021","journal-title":"Circulation"},{"issue":"11","key":"2026072521091977000_cit32","doi-asserted-by":"publisher","first-page":"3465","DOI":"10.1161\/STROKEAHA.122.039961","article-title":"Differentiation\nof fibroblasts into myofibroblasts in the arachnoid membrane of moyamoya\ndisease","volume":"53","author":"Yamamoto","year":"2022","journal-title":"Stroke"},{"issue":"1","key":"2026072521091977000_cit33","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-01304-4","article-title":"A deep\nlearning approach to identify\nand segment alpha-smooth muscle actin stress fiber positive cells","volume":"11","author":"Hillsley","year":"2021","journal-title":"Sci. Rep-Uk"},{"key":"2026072521091977000_cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.141415","article-title":"Oxygen vacancies-rich\n\u03b1@ \u03b4-MnO2 mediated\nactivation of peroxymonosulfate for the degradation of CIP: The role\nof electron transfer process on the surface","volume":"458","author":"Zhu","year":"2023","journal-title":"Chemical engineering journal"},{"issue":"2","key":"2026072521091977000_cit35","doi-asserted-by":"publisher","first-page":"154","DOI":"10.3390\/bioengineering12020154","article-title":"Cardiomyocytes in\nHypoxia: Cellular\nResponses and Implications for Cell-Based Cardiac Regenerative Therapies","volume":"12","author":"Dwyer","year":"2025","journal-title":"Bioengineering"},{"key":"2026072521091977000_cit36","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/s12012-021-09696-5","article-title":"Oxygen delivery\napproaches to augment cell survival after myocardial infarction: progress\nand challenges","volume":"22","author":"Jenabi","year":"2022","journal-title":"Cardiovascular Toxicology"},{"issue":"5","key":"2026072521091977000_cit37","doi-asserted-by":"publisher","first-page":"5945","DOI":"10.1021\/acsami.0c19633","article-title":"Catalase-loaded\nsilica nanoparticles formulated via direct surface modification as\npotential oxygen generators for hypoxia relief","volume":"13","author":"Heble","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"1","key":"2026072521091977000_cit38","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s12951-024-03060-9","article-title":"Therapeutic delivery\nof oxygen using artificial oxygen carriers demonstrates the possibility\nof treating a wide range of diseases","volume":"23","author":"Mohanto","year":"2025","journal-title":"J. Nanobiotechnol."},{"issue":"17","key":"2026072521091977000_cit39","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202308235","article-title":"Hybrid ginseng-derived\nextracellular vesicles-like particles with\nautologous tumor cell membrane for personalized vaccination to inhibit\ntumor recurrence and metastasis","volume":"11","author":"Wang","year":"2024","journal-title":"Advanced science"}],"container-title":["ACS Applied Materials &amp;\nInterfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.5c01964","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/aamick\/article-pdf\/17\/29\/41626\/66267025\/acsami.5c01964.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/aamick\/article-pdf\/17\/29\/41626\/66267025\/acsami.5c01964.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T13:41:54Z","timestamp":1785073314000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/aamick\/article\/17\/29\/41626\/3638459\/Ameliorating-Myocardial-Infarction-by-Concurrent"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,8]]},"references-count":39,"journal-issue":{"issue":"29","published-online":{"date-parts":[[2025,7,8]]},"published-print":{"date-parts":[[2025,7,23]]}},"URL":"https:\/\/doi.org\/10.1021\/acsami.5c01964","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,8]]}}}