{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T15:12:10Z","timestamp":1792336330351,"version":"4.4.0"},"reference-count":63,"publisher":"American Chemical Society (ACS)","issue":"24","license":[{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL098217"],"award-info":[{"award-number":["HL098217"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-22-1-0931"],"award-info":[{"award-number":["W81XWH-22-1-0931"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001422","name":"American Society of Hematology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001422","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011597","name":"Penn State Hershey Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011597","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Appl. Mater. Interfaces"],"published-print":{"date-parts":[[2025,6,18]]},"DOI":"10.1021\/acsami.5c02984","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T19:36:57Z","timestamp":1749065817000},"page":"35056-35065","source":"Crossref","is-referenced-by-count":2,"title":["Differentiating Aggressive from Nonaggressive Prostate Cancer Using Unconjugated Contrast Agents"],"prefix":"10.1021","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4453-488X","authenticated-orcid":true,"given":"Bhawna","family":"Saini","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering","place":["University Park, United States"]},{"name":"Pennsylvania State University","place":["University Park, United States"]},{"name":"College of Medicine, Department of Biochemistry and Molecular Biology","place":["Hershey, United States"]},{"name":"Pennsylvania State University","place":["Hershey, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6472-4070","authenticated-orcid":true,"given":"Aayushi","family":"Laliwala","sequence":"additional","affiliation":[{"name":"Department of Radiology","place":["Cleveland, United States"]},{"name":"Case Western Reserve University","place":["Cleveland, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishika","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering","place":["University Park, United States"]},{"name":"Pennsylvania State University","place":["University Park, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3913-7066","authenticated-orcid":true,"given":"Agata A.","family":"Exner","sequence":"additional","affiliation":[{"name":"Department of Radiology","place":["Cleveland, United States"]},{"name":"Case Western Reserve University","place":["Cleveland, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8613-8649","authenticated-orcid":true,"given":"Gail","family":"Matters","sequence":"additional","affiliation":[{"name":"College of Medicine, Department of Biochemistry and Molecular Biology","place":["Hershey, United States"]},{"name":"Pennsylvania State University","place":["Hershey, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1977-1046","authenticated-orcid":true,"given":"Xu","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Pharmacology","place":["Cleveland, United States"]},{"name":"Case Western Reserve University","place":["Cleveland, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2602-023X","authenticated-orcid":true,"given":"Marvin T.","family":"Nieman","sequence":"additional","affiliation":[{"name":"Department of Pharmacology","place":["Cleveland, United States"]},{"name":"Case Western Reserve University","place":["Cleveland, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sri-Rajasekhar","family":"Kothapalli","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering","place":["University Park, United States"]},{"name":"Pennsylvania State University","place":["University Park, United States"]},{"name":"Penn State Cancer Institute","place":["Hershey, United States"]},{"name":"Pennsylvania State University","place":["Hershey, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,6,4]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21871"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12041526"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/s41585-020-00400-w"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01042-7"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16030523"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15205047"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.20517\/cdr.2022.15"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13020487"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.05.049"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13132283"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.32074\/1591-951X-925"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.omto.2021.06.007"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.16151414"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1976.40.4.575"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/940585"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42712-6"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-023-01105-2"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1718917115"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1039\/D4NR00283K"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2016.04.001"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-47063-4"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aav2169"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aad1278"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-022-00615-3"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3929"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.4c00651"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1007\/BF03353743"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25452-3"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10081"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.7150\/thno.22872"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32837-5"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/nn403527r"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2018180666"},{"key":"ref34\/cit34","first-page":"S817","volume":"18","author":"Kothapalli S. R.","year":"2016","journal-title":"Mol. Imaging Biol."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","unstructured":"Qin, R.; Xu, J.; Xu, R.; Kim, C.; Wang, L. V. Fabricating Multifunctional Microbubbles and Nanobubbles for Concurrent Ultrasound and Photoacoustic Imaging; Nordstrom, R. J., Ed. San Francisco, CA, 2010; p 75670L.","DOI":"10.1117\/12.841281"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S243548"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.1102651"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-014-0088-9"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1038\/s41427-018-0066-x"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.06.008"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-91252-w"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.111.099754"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-84072-5"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2020.102213"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-021-00394-5"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.4c00137"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.9b00462"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1039\/C9NR04828F"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2089"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14081740"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1039\/c8pp00064f"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1166\/jnn.2021.19514"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-020-00603-8"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.2007"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2015.07.024"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00644"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-020-00650-1"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/606415"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16327-z"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1038\/srep10420"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1039\/C6CS00636A"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-021-00858-8"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.7150\/thno.19841"}],"container-title":["ACS Applied Materials & Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.5c02984","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.5c02984","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T08:25:48Z","timestamp":1750235148000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsami.5c02984"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,4]]},"references-count":63,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2025,6,18]]}},"alternative-id":["10.1021\/acsami.5c02984"],"URL":"https:\/\/doi.org\/10.1021\/acsami.5c02984","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,4]]}}}