{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T13:13:40Z","timestamp":1792502020347,"version":"4.5.0"},"reference-count":42,"publisher":"American Chemical Society (ACS)","issue":"30","license":[{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"name":"Tianjin Health Research Project","award":["TJWJ2021MS038"],"award-info":[{"award-number":["TJWJ2021MS038"]}]},{"name":"Jinan Clinical Medical Science and Technology Innovation Plan","award":["202225066"],"award-info":[{"award-number":["202225066"]}]},{"name":"Tianjin Research Program of Application Foundation","award":["21JCYBJC01340"],"award-info":[{"award-number":["21JCYBJC01340"]}]},{"name":"Tianjin Research Program of Application Foundation","award":["22JCZXJC00080"],"award-info":[{"award-number":["22JCZXJC00080"]}]},{"name":"Tianjin Research Program of Application Foundation","award":["S22ZDF291"],"award-info":[{"award-number":["S22ZDF291"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Appl. Mater. Interfaces"],"published-print":{"date-parts":[[2025,7,30]]},"DOI":"10.1021\/acsami.5c06750","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T14:36:33Z","timestamp":1752762993000},"page":"42658-42673","source":"Crossref","is-referenced-by-count":12,"title":["Engineered EVs from 3D-Cultured MSCs for Synergistic Modulation of Inflammatory Microenvironment and Cartilage Regeneration in Osteoarthritis"],"prefix":"10.1021","volume":"17","author":[{"given":"Shuang","family":"Fu","sequence":"first","affiliation":[{"name":"Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences","place":["Tianjin, China"]},{"name":"Nankai University","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukang","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences","place":["Tianjin, China"]},{"name":"Nankai University","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences","place":["Tianjin, China"]},{"name":"Nankai University","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences","place":["Tianjin, China"]},{"name":"Nankai University","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinpeng","family":"Wan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences","place":["Tianjin, China"]},{"name":"Nankai University","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Occlusion and Temporomandibular Joint Diseases, Tianjin Stomatological Hospital, School of Medicine","place":["Tianjin, P. R. China"]},{"name":"Nankai University","place":["Tianjin, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences","place":["Tianjin, China"]},{"name":"Nankai University","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Occlusion and Temporomandibular Joint Diseases, Tianjin Stomatological Hospital, School of Medicine","place":["Tianjin, P. R. China"]},{"name":"Nankai University","place":["Tianjin, P. R. China"]},{"name":"Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction","place":["Tianjin, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0335-6024","authenticated-orcid":true,"given":"Shufang","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences","place":["Tianjin, China"]},{"name":"Nankai University","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,7,17]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30417-9"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2017.07.004"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1903768"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2022.11.021"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1039\/D3MH00218G"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c04241"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c00909"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2019.12.007"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.116786"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202005513"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-00523-9"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2021.09.033"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2022.121802"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202107354"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-018-0123-4"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2021.12.004"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202204814"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.10.012"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2016.11.008"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-023-02050-7"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202201384"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aav8521"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2023.120924"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau6977"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.154432"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-021-00991-5"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2024.04.007"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202101479"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2022.102814"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120293"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23158662"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2022.112646"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2018.05.021"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.11.028"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-061616-030146"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.06.110"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1002\/stem.3242"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2020.01.007"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1111\/os.14302"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.120967"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2016.08.068"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.118453"}],"container-title":["ACS Applied Materials &amp; Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.5c06750","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.5c06750","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:16:18Z","timestamp":1753863378000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsami.5c06750"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,17]]},"references-count":42,"journal-issue":{"issue":"30","published-print":{"date-parts":[[2025,7,30]]}},"alternative-id":["10.1021\/acsami.5c06750"],"URL":"https:\/\/doi.org\/10.1021\/acsami.5c06750","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,17]]}}}