{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:21:11Z","timestamp":1791937271654,"version":"4.3.4"},"reference-count":37,"publisher":"American Chemical Society (ACS)","issue":"26","license":[{"start":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100016319","name":"China National Biotec Group Company","doi-asserted-by":"publisher","award":["CNBG-FNJ-003"],"award-info":[{"award-number":["CNBG-FNJ-003"]}],"id":[{"id":"10.13039\/501100016319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Appl. Mater. Interfaces"],"published-print":{"date-parts":[[2025,7,2]]},"DOI":"10.1021\/acsami.5c08444","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T12:15:14Z","timestamp":1750248914000},"page":"37763-37773","source":"Crossref","is-referenced-by-count":15,"title":["Lipid Nanoparticles Consisting of Sterol-Conjugated Ionizable Lipids Enable Prolonged and Safe mRNA Delivery"],"prefix":"10.1021","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9547-0659","authenticated-orcid":true,"given":"Chenglong","family":"Wang","sequence":"first","affiliation":[{"name":"CNBG-Virogin Biotech (Shanghai) Co., Ltd.","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Zhou","sequence":"additional","affiliation":[{"name":"CNBG-Virogin Biotech (Shanghai) Co., Ltd.","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxia","family":"Gao","sequence":"additional","affiliation":[{"name":"CNBG-Virogin Biotech (Shanghai) Co., Ltd.","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinping","family":"Pan","sequence":"additional","affiliation":[{"name":"CNBG-Virogin Biotech (Shanghai) Co., Ltd.","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Jia","sequence":"additional","affiliation":[{"name":"CNBG-Virogin Biotech (Shanghai) Co., Ltd.","place":["Shanghai, China"]},{"name":"Shanghai-Virogin Biotech Co., Ltd.","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4189-4469","authenticated-orcid":true,"given":"Tengjie","family":"Wu","sequence":"additional","affiliation":[{"name":"CNBG-Virogin Biotech (Shanghai) Co., Ltd.","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuntao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Sinopharm Group China National Biotech Group (CNBG) Co., Ltd.","place":["Beijing, China"]},{"name":"State key Laboratory of Novel Vaccines for Emerging Infectious Diseases","place":["Beijing, China"]},{"name":"China National Biotech Group (CNBG) Co., Ltd.","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,6,18]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-022-01294-2"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-022-01491-z"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-023-00811-9"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2023.105668"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-021-00358-0"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c00244"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1002\/EXP.20230147"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-021-00439-4"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2022.114416"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1002\/bmm2.12116"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2022.04.011"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","unstructured":"Liu, Y.; Liu, Q.; Zhang, B.Generation of tolerogenic antigen-presenting cells in vivo via the delivery of mRNA encoding PDL1 within lipid nanoparticles Nat. Biomed. Eng. 2025 10.1038\/s41551-025-01373-0.","DOI":"10.1038\/s41551-025-01373-0"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2018.03.010"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1126\/science.ads4539"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-08758-w"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2020.12.006"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.01.008"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2020.01.008"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2021.09.016"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1039\/D3TB00649B"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.10.028"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202303261"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-02061-1"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1894"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c14203"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-14527-2"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c21289"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.2554"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2024.2392661"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.11.073"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202013927"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.0c01386"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-023-01679-x"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c20077"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2021.123015"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-018-0943-8"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c07822"}],"container-title":["ACS Applied Materials & Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.5c08444","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.5c08444","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T08:14:42Z","timestamp":1751444082000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsami.5c08444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,18]]},"references-count":37,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2025,7,2]]}},"alternative-id":["10.1021\/acsami.5c08444"],"URL":"https:\/\/doi.org\/10.1021\/acsami.5c08444","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,18]]}}}