{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:26:35Z","timestamp":1791235595058,"version":"4.1.0"},"reference-count":42,"publisher":"American Chemical Society (ACS)","issue":"29","license":[{"start":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T00:00:00Z","timestamp":1752278400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T00:00:00Z","timestamp":1752278400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T00:00:00Z","timestamp":1752278400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100011204","name":"State Key Laboratory for Modification of Chemical Fibers and Polymer Materials","doi-asserted-by":"publisher","award":["KF2411"],"award-info":[{"award-number":["KF2411"]}],"id":[{"id":"10.13039\/501100011204","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015378","name":"Shanghai University of Medicine and Health Sciences","doi-asserted-by":"publisher","award":["SSF-24-21-03"],"award-info":[{"award-number":["SSF-24-21-03"]}],"id":[{"id":"10.13039\/501100015378","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Innovation 2030 Major Projects","award":["2022ZD0211600"],"award-info":[{"award-number":["2022ZD0211600"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Diabetic wound healing remains a persistent clinical challenge where exudate management and targeted disinfection constitute critical therapeutic priorities. Drawing inspiration from nature\u2019s asymmetric wettability in Janus-structured lotus leaves, we engineered a biomimetic wound dressing system that synergistically integrates directional biofluid transport and photothermal\/photodynamic sterilization. The hierarchically structured PP\/PAN-xCu-TCPP fiber dressing combines a hydrophobic polypropylene (PP) substrate with an electrospun polyacrylonitrile (PAN) nanofibrous matrix incorporating copper-porphyrin metal\u2013organic frameworks (Cu-TCPP MOFs). This Janus architecture orchestrates unidirectional fluid dynamics via surface tension and contact angle differentials from the hydrophobic to the hydrophilic layer, effectively preventing exudate accumulation while maintaining physiologically moist microenvironments. The PP\/PAN-20%Cu-TCPP fiber dressing confers spatiotemporal therapeutic control under near-infrared (NIR) irradiation, generating reactive oxygen species (ROS) and photothermal bactericidal effects. In Staphylococcus aureus-infected diabetic mice models, the dual-laser activated PP\/PAN-20%Cu-TCPP system demonstrates excellent microbial eradication, immunomodulation by suppressing hyperinflammation and directing macrophage polarization toward regenerative M2 phenotypes, and angiogenic potentiation via dual phototherapeutic activation of endothelial cells and stromal remodeling. This multifunctional paradigm effectively bridges the critical gap between infection control and pro-regenerative microenvironment establishment, thereby accelerating wound repair.<\/jats:p>","DOI":"10.1021\/acsami.5c10274","type":"journal-article","created":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T12:58:02Z","timestamp":1752325082000},"page":"41825-41837","source":"Crossref","is-referenced-by-count":8,"title":["Bionic\nJanus Fiber\nEnabling Autonomous Exudate Management\nand Multimodal Sterilization for Diabetic Wounds"],"prefix":"10.1021","volume":"17","author":[{"given":"Qian","family":"Ren","sequence":"first","affiliation":[{"name":"Shanghai University of Medicine & Health Sciences , , ,","place":["Shanghai, China, 201318"]},{"name":"Donghua University , , ,","place":["Shanghai, China, 201620"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dali","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai University of Medicine & Health Sciences , , ,","place":["Shanghai, China, 201318"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Song","sequence":"additional","affiliation":[{"name":"Shanghai University of Medicine & Health Sciences , , ,","place":["Shanghai, China, 201318"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai University of Medicine & Health Sciences , , ,","place":["Shanghai, China, 201318"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4709-7378","authenticated-orcid":true,"given":"Qiwei","family":"Tian","sequence":"additional","affiliation":[{"name":"Donghua University , , ,","place":["Shanghai, China, 201620"]},{"name":"Shanghai University of Medicine & Health Sciences , , ,","place":["Shanghai, China, 201318"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wu","sequence":"additional","affiliation":[{"name":"Shanghai University of Medicine & Health Sciences , , ,","place":["Shanghai, China, 201318"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7459-2705","authenticated-orcid":true,"given":"Weidong","family":"Le","sequence":"additional","affiliation":[{"name":"Shanghai University of Medicine & Health Sciences , , ,","place":["Shanghai, China, 201318"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,7,12]]},"reference":[{"key":"2026072521082671500_cit1","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1007\/s42765-022-00239-3","article-title":"Trilayered Fibrous Dressing with Wettability Gradient\nfor Spontaneous and Directional Transport of Massive Exudate and Wound\nHealing Promotion","volume":"5","author":"Liu","year":"2023","journal-title":"Adv. Fiber Mater."},{"key":"2026072521082671500_cit2","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1007\/s42765-022-00141-y","article-title":"Batch Preparation\nand Characterization of Electrospun\nPorous Polylactic Acid-based Nanofiber Membranes for Antibacterial\nWound Dressing","volume":"4","author":"Yin","year":"2022","journal-title":"Adv. Fiber Mater."},{"key":"2026072521082671500_cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121040","article-title":"Nanofibrous\nComposite Aerogel with Multi-bioactive\nand Fluid Gating Characteristics for Promoting Diabetic Wound Healing","volume":"276","author":"Zhang","year":"2021","journal-title":"Biomaterials"},{"key":"2026072521082671500_cit4","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.681710","article-title":"Macrophage Related\nChronic Inflammation in Non-healing Wounds","volume":"12","author":"Li","year":"2021","journal-title":"Front. Immunol."},{"key":"2026072521082671500_cit5","doi-asserted-by":"publisher","first-page":"2720","DOI":"10.1182\/blood-2005-08-3140","article-title":"The Extracellular Adherence\nProtein (Eap) of Staphylococcus Aureus Inhibits Wound\nHealing by Interfering with Host Defense and Repair Mechanisms","volume":"107","author":"Athanasopoulos","year":"2006","journal-title":"Blood"},{"key":"2026072521082671500_cit6","doi-asserted-by":"publisher","first-page":"125","DOI":"10.12968\/jowc.2003.12.4.26484","article-title":"Importance\nof\nMoisture Balance at the Wound-dressing Interface","volume":"12","author":"Bishop","year":"2003","journal-title":"J. Wound Care"},{"key":"2026072521082671500_cit7","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202214089","article-title":"Multiple Stimuli-responsive\nNanozyme-based Cryogels with Controlled NO Release as Self-adaptive\nWound Dressing for Infected Wound Healing","volume":"33","author":"Yang","year":"2023","journal-title":"Adv.\nFunct. Mater."},{"key":"2026072521082671500_cit8","doi-asserted-by":"publisher","first-page":"2670","DOI":"10.1002\/pmic.201200502","article-title":"Proteome Analysis\nReveals Antiangiogenic Environments\nin Chronic Wounds of Diabetes Mellitus Type 2 Patients","volume":"13","author":"Krisp","year":"2013","journal-title":"Proteomics"},{"key":"2026072521082671500_cit9","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1038\/nature07201","article-title":"Origin and\nPhysiological Roles of Inflammation","volume":"454","author":"Medzhitov","year":"2008","journal-title":"Nature"},{"key":"2026072521082671500_cit10","doi-asserted-by":"publisher","first-page":"9984","DOI":"10.1002\/anie.201604827","article-title":"On-demand\nDissolution of a Dendritic Hydrogel-based\nDressing for Second-degree Burn Wounds through Thiol-thioester Exchange\nReaction","volume":"55","author":"Konieczynska","year":"2016","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026072521082671500_cit11","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202200799","article-title":"Secretory\nFluid-Aggregated Janus\nElectrospun Short Fiber Scaffold for Wound Healing","volume":"18","author":"Qian","year":"2022","journal-title":"Small"},{"key":"2026072521082671500_cit12","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202315020","article-title":"Janus Nanofiber\nMembranes with Photothermal-enhanced\nBiofluid Drainage and Sterilization for Diabetic Wounds","volume":"34","author":"Zhang","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"2026072521082671500_cit13","doi-asserted-by":"publisher","first-page":"12984","DOI":"10.1021\/acsami.1c22629","article-title":"A Multifunctional Janus Electrospun\nNanofiber Dressing with Biofluid Draining, Monitoring, and Antibacterial\nProperties for Wound Healing","volume":"14","author":"Zhang","year":"2022","journal-title":"ACS Appl. Mater.\nInterfaces"},{"key":"2026072521082671500_cit14","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202005422","article-title":"Bioactive Self-pumping Composite Wound Dressings with\nMicropore Array Modified Janus Membrane for Enhanced Diabetic Wound\nHealing","volume":"30","author":"Bao","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"2026072521082671500_cit15","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201801495","article-title":"Janus Membranes: Creating Asymmetry for Energy Efficiency","volume":"30","author":"Yang","year":"2018","journal-title":"Adv. Mater."},{"key":"2026072521082671500_cit16","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1007\/s42765-020-00034-y","article-title":"Electrospun\nNanofibrous Materials\nfor Wound Healing","volume":"2","author":"Dong","year":"2020","journal-title":"Adv. Fiber Mater."},{"key":"2026072521082671500_cit17","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.bioactmat.2022.01.045","article-title":"Graphene-based\nNanomaterials for Cancer Therapy and Anti-infections","volume":"14","author":"Wang","year":"2022","journal-title":"Bioact. 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Hazard. 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Eng. J."},{"key":"2026072521082671500_cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.150945","article-title":"Light-responsive\nAu@Zn-TCPP Nanozyme\nFunctionalized with Cell-penetrating Peptide and Antisense Oligonucleotide\nfor Sensing Living Bacteria and Synergistic Therapy of Diabetic Wounds","volume":"488","author":"Zhang","year":"2024","journal-title":"Chem. Eng. J."},{"key":"2026072521082671500_cit27","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/j.jcis.2024.03.176","article-title":"Copper Selenide\nNanosheets with Photothermal Therapy-related\nProperties and Multienzyme Activity for Highly Effective Eradication\nof Drug Resistance","volume":"666","author":"Li","year":"2024","journal-title":"J. Colloid Interface Sci."},{"key":"2026072521082671500_cit28","doi-asserted-by":"publisher","first-page":"4086","DOI":"10.7150\/thno.25433","article-title":"Ultrathin\nCu-TCPP MOF Nanosheets:\nA New Theragnostic Nanoplatform with Magnetic Resonance\/Near-infrared\nThermal Imaging for Synergistic Phototherapy of Cancers","volume":"8","author":"Li","year":"2018","journal-title":"Theranostics"},{"key":"2026072521082671500_cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2022.102686","article-title":"Copper-based Metal-organic Frameworks for Biomedical Applications","volume":"305","author":"Cun","year":"2022","journal-title":"Adv. Colloid Interface Sci."},{"key":"2026072521082671500_cit30","doi-asserted-by":"publisher","first-page":"32799","DOI":"10.1021\/acsami.2c04323","article-title":"Biomimetic Asymmetric Composite Dressing\nby Electrospinning with Aligned Nanofibrous and Micropatterned Structures\nfor Severe Burn Wound Healing","volume":"14","author":"He","year":"2022","journal-title":"ACS Appl. Mater.\nInterfaces"},{"key":"2026072521082671500_cit31","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202000872","article-title":"Biodegradable and Electroactive\nRegenerated Bacterial Cellulose\/MXene (Ti3C2Tx) Composite Hydrogel as Wound Dressing for Accelerating\nSkin Wound Healing under Electrical Stimulation","volume":"9","author":"Mao","year":"2020","journal-title":"Adv. Healthcare Mater."},{"key":"2026072521082671500_cit32","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1007\/s10544-012-9651-x","article-title":"Concentration-dependent\nCytotoxicity of Copper Ions on Mouse Fibroblasts in Vitro: Effects of Copper Ion Release from TCu380A vs TCu220C Intra-uterine\nDevices","volume":"14","author":"Cao","year":"2012","journal-title":"Biomed. Microdevices"},{"key":"2026072521082671500_cit33","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.biomaterials.2018.01.048","article-title":"Lysosomal Deposition\nof Copper Oxide Nanoparticles Triggers HUVEC Cells Death","volume":"161","author":"Zhang","year":"2018","journal-title":"Biomaterials"},{"key":"2026072521082671500_cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.130838","article-title":"Study on Synergistic\nMechanism of Molybdenum Disulfide\/Sodium Carboxymethyl Cellulose Composite\nNanofiber Mats for Photothermal\/Photodynamic Antibacterial Treatment","volume":"266","author":"Xu","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"2026072521082671500_cit35","doi-asserted-by":"publisher","first-page":"8459","DOI":"10.1021\/acsami.3c17955","article-title":"Postsynthetic Modification\nof Thermo-treated Metal-organic Framework\nfor Combined Photothermal\/Photodynamic Antibacterial Therapy","volume":"16","author":"Li","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"2026072521082671500_cit36","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1016\/j.jcis.2024.10.137","article-title":"Multifunctional Janus Nanofibrous Membrane with Unidirectional\nWater Transport and pH-Responsive Color-changing for Wound Dressing","volume":"679","author":"Guo","year":"2025","journal-title":"J. Colloid Interface Sci."},{"key":"2026072521082671500_cit37","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202107300","article-title":"Photosensitizer Nanodot\nEliciting Immunogenicity for Photo-immunologic\nTherapy of Postoperative Methicillin-resistant Staphylococcus Aureus Infection and Secondary Recurrence","volume":"34","author":"Tang","year":"2022","journal-title":"Adv. Mater."},{"key":"2026072521082671500_cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.150002","article-title":"Glu and GSH\nDouble-unlocked Immunomodulatory Tri-cascade Nanoreactor for Biofilm-infected\nDiabetic Wounds Healing","volume":"485","author":"Zhao","year":"2024","journal-title":"Chem. Eng. J."},{"key":"2026072521082671500_cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2022.102816","article-title":"Effects of\nALA-PDT on the Macrophages in Wound Healing\nand its Related Mechanisms in Vivo and in Vitro","volume":"38","author":"Li","year":"2022","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"2026072521082671500_cit40","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202202691","article-title":"Regulation of Macrophage\nPolarization Through Periodic Photo-thermal Treatment to Facilitate\nOsteogenesis","volume":"18","author":"Li","year":"2022","journal-title":"Small"},{"key":"2026072521082671500_cit41","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202400003","article-title":"An Immune-regulating\nPolysaccharide Hybrid Hydrogel with Mild Photothermal Effect and Anti-inflammatory\nfor Accelerating Infected Wound Healing","author":"Zhou","year":"2024","journal-title":"Adv.\nHealthcare Mater."},{"key":"2026072521082671500_cit42","doi-asserted-by":"publisher","first-page":"6581","DOI":"10.1021\/acsnano.9b00489","article-title":"A Biomimetic Hierarchical\nNanointerface Orchestrates Macrophage Polarization and Mesenchymal\nStem Cell Recruitment To Promote Endogenous Bone Regeneration","volume":"13","author":"Jin","year":"2019","journal-title":"ACS Nano"}],"container-title":["ACS Applied Materials &amp;\nInterfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.5c10274","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/aamick\/article-pdf\/17\/29\/41825\/66266563\/acsami.5c10274.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/aamick\/article-pdf\/17\/29\/41825\/66266563\/acsami.5c10274.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T13:40:41Z","timestamp":1785073241000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/aamick\/article\/17\/29\/41825\/3638571\/Bionic-Janus-Fiber-Enabling-Autonomous-Exudate"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,12]]},"references-count":42,"journal-issue":{"issue":"29","published-online":{"date-parts":[[2025,7,12]]},"published-print":{"date-parts":[[2025,7,23]]}},"URL":"https:\/\/doi.org\/10.1021\/acsami.5c10274","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,12]]}}}