{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:25:56Z","timestamp":1790699156380,"version":"4.1.0"},"reference-count":76,"publisher":"American Chemical Society (ACS)","issue":"32","license":[{"start":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T00:00:00Z","timestamp":1751932800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci?n y Universidades","doi-asserted-by":"publisher","award":["PID2021-127847OB-I00"],"award-info":[{"award-number":["PID2021-127847OB-I00"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci?n y Universidades","doi-asserted-by":"publisher","award":["RTI2018-096172-B-C33"],"award-info":[{"award-number":["RTI2018-096172-B-C33"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci?n","doi-asserted-by":"publisher","award":["CEX2023- 001286-S"],"award-info":[{"award-number":["CEX2023- 001286-S"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Appl. Mater. Interfaces"],"published-print":{"date-parts":[[2025,8,13]]},"DOI":"10.1021\/acsami.5c10402","type":"journal-article","created":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T07:19:03Z","timestamp":1751959143000},"page":"45538-45554","source":"Crossref","is-referenced-by-count":4,"title":["Biomimetic Apatite Nanoparticles and Microcrystalline Tyrosine as Biocompatible Vaccine Adjuvants: Performance in a Bluetongue Virus Sheep Model"],"prefix":"10.1021","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0844-6026","authenticated-orcid":true,"given":"Estela","family":"P\u00e9rez","sequence":"first","affiliation":[{"name":"Department of Animal Pathology, University of Zaragoza, 177 Miguel Servet Street, Zaragoza 50013, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00edctor","family":"Sebasti\u00e1n","sequence":"additional","affiliation":[{"name":"Institute of Nanoscience and Materials of Aragon (INMA), CSIC-University of Zaragoza, Mariano Esquillor G\u00f3mez Street I+D+i building, Zaragoza 50018, Spain"},{"name":"Department of Chemical and Environmental Engineering, University of Zaragoza, Mar\u00eda de Luna 3 Street, Zaragoza 50018, Spain"},{"name":"Advanced Microscopy Laboratory, University of Zaragoza, Mariano Esquillor G\u00f3mez Street I+D+i building, Zaragoza 50018, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Rodr\u00edguez-Largo","sequence":"additional","affiliation":[{"name":"Department of Animal Pathology, University of Zaragoza, 177 Miguel Servet Street, Zaragoza 50013, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"de Miguel","sequence":"additional","affiliation":[{"name":"Department of Animal Pathology, University of Zaragoza, 177 Miguel Servet Street, Zaragoza 50013, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lex","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Department of Animal Pathology, University of Zaragoza, 177 Miguel Servet Street, Zaragoza 50013, Spain"},{"name":"Agri-Food Institute of Aragon (IA2), University of Zaragoza, 177 Miguel Servet Street, Zaragoza 50013, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias F.","family":"Kramer","sequence":"additional","affiliation":[{"name":"Bencard Adjuvant Systems, Allergy Therapeutics PLC, Dominion Way Street, Worthing BN14 8SA, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Graessel","sequence":"additional","affiliation":[{"name":"Bencard Adjuvant Systems, Allergy Therapeutics PLC, Dominion Way Street, Worthing BN14 8SA, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bel\u00e9n","family":"Parra-Torrej\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Inorganic Chemistry, University of Granada, Fuentenueva avenue, Granada 18071, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Manuel","family":"Delgado-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Department of Inorganic Chemistry, University of Granada, Fuentenueva avenue, Granada 18071, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Utrilla-Trigo","sequence":"additional","affiliation":[{"name":"Center of Research in Animal Health (CISA-INIA, CSIC), Algete-El Casar road, km. 8.1, Madrid 28130, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Jim\u00e9nez-Cabello","sequence":"additional","affiliation":[{"name":"Center of Research in Animal Health (CISA-INIA, CSIC), Algete-El Casar road, km. 8.1, Madrid 28130, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Ortego","sequence":"additional","affiliation":[{"name":"Center of Research in Animal Health (CISA-INIA, CSIC), Algete-El Casar road, km. 8.1, Madrid 28130, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1204-4356","authenticated-orcid":true,"given":"Ignacio","family":"de Blas","sequence":"additional","affiliation":[{"name":"Agri-Food Institute of Aragon (IA2), University of Zaragoza, 177 Miguel Servet Street, Zaragoza 50013, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rams\u00e9s","family":"Reina","sequence":"additional","affiliation":[{"name":"Institute of Agrobiotechnology, CSIC-Government of Navarra, Avenue of Pamplona, Mutilva 31192, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Agri-Food Institute of Aragon (IA2), University of Zaragoza, 177 Miguel Servet Street, Zaragoza 50013, Spain"},{"name":"Department of Anatomy, Embryology and Genetics, University of Zaragoza, 177 Miguel Servet Street, Zaragoza 50013, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2053-9842","authenticated-orcid":true,"given":"Llu\u00eds","family":"Luj\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Animal Pathology, University of Zaragoza, 177 Miguel Servet Street, Zaragoza 50013, Spain"},{"name":"Agri-Food Institute of Aragon (IA2), University of Zaragoza, 177 Miguel Servet Street, Zaragoza 50013, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,7,8]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1080\/10408444.2022.2105688"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-018-0089-x"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2020.126632"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2015.00004"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1177\/0300985818809142"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1007\/s11259-025-10679-y"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2024.11.002"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1984.01650460058020"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2004.06.058"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-013-8404-0"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12358"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2019.00407"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1586\/erv.10.97"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2015.07.018"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-018-9059-7"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2021.126822"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1111\/all.14134"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1080\/14760584.2017.1244484"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2018.07.036"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.3389\/fmats.2021.788373"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-019-1530-9"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.26717\/BJSTR.2020.27.004500"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2012.04.046"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcrysgrow.2012.11.001"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.594911"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1002\/jat.869"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1800035"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2022.06.064"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2016.00048"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1038\/srep31578"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jssc.2015.11.007"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00320-13"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2004.07.050"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00427-07"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1002\/adem.200980084"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.31447"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1039\/C9RA03831K"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1039\/D2MA00546H"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1002\/pen.26501"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2015.08.007"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1126\/science.127.3308.1239"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1100\/2012\/147158"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2013.05.032"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1007\/s11259-006-3313-5"},{"issue":"83","key":"ref45\/cit45","first-page":"55","author":"Stott J. L.","year":"1979","journal-title":"Proc. Annu. Meet. U. S. Anim. Health Assoc."},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1590\/S1516-89132013005000002"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines12121326"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2007.04.017"},{"key":"ref49\/cit49","first-page":"321","volume":"30","author":"Relyveld E. H.","year":"1964","journal-title":"Bull. World Health Organ."},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1007\/s12274-022-4683-x"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2010.09.008"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.2903\/sp.efsa.2017.EN-1182"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2008.06.010"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2014.1698"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2427(97)00084-6"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026666"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2008.05.032"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.3390\/v13081455"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010616504811"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1177\/0192623312448935"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-70794-9"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3330"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5b02624"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2006.02.004"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.11.018"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2019.e01911"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2016.05.007"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-184556"},{"issue":"3","key":"ref69\/cit69","first-page":"156","volume":"45","author":"Seeber S. J.","year":"1991","journal-title":"J. Parenter. Sci. Technol."},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-005-1704-1"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2022.09.007"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1080\/01926230600964722"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-30336-1"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01614-21"},{"key":"ref75\/cit75","first-page":"24","volume-title":"WOAH Terrestrial Manual","author":"World Organisation for Animal Health","year":"2021"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2005.03.001"}],"container-title":["ACS Applied Materials &amp; Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.5c10402","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.5c10402","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T08:13:33Z","timestamp":1755072813000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsami.5c10402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,8]]},"references-count":76,"journal-issue":{"issue":"32","published-print":{"date-parts":[[2025,8,13]]}},"alternative-id":["10.1021\/acsami.5c10402"],"URL":"https:\/\/doi.org\/10.1021\/acsami.5c10402","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,8]]}}}