{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:25:47Z","timestamp":1790778347506,"version":"4.1.0"},"reference-count":71,"publisher":"American Chemical Society (ACS)","issue":"45","license":[{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32370797"],"award-info":[{"award-number":["32370797"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473195"],"award-info":[{"award-number":["82473195"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LTGY23H160018"],"award-info":[{"award-number":["LTGY23H160018"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Laboratory of Prevention, Diagnosis and Therapy of Upper Gastrointestinal Cancer of Zhejiang Province","award":["2022E10021"],"award-info":[{"award-number":["2022E10021"]}]},{"name":"National Research Center for Translational Medicine at Shanghai Program","award":["NRCTM(SH)-2025-07"],"award-info":[{"award-number":["NRCTM(SH)-2025-07"]}]},{"name":"Zhejiang Medical and Health Science and Technology Program","award":["2024KY789"],"award-info":[{"award-number":["2024KY789"]}]},{"name":"Beijing Science and Technology Innovation Medical Development Foundation","award":["KC2023-JX-0270-07"],"award-info":[{"award-number":["KC2023-JX-0270-07"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Appl. Mater. Interfaces"],"published-print":{"date-parts":[[2025,11,12]]},"DOI":"10.1021\/acsami.5c13198","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T15:04:45Z","timestamp":1761750285000},"page":"61676-61694","source":"Crossref","is-referenced-by-count":9,"title":["Dual-Targeted Biomimetic Nanoparticles for Enhanced Delivery of Polyphyllin B Synergistically Induce Ferroptosis and Immunogenic Cell Death in Gastric Cancer"],"prefix":"10.1021","volume":"17","author":[{"given":"Dan","family":"Zu","sequence":"first","affiliation":[{"name":"School of Life Sciences","place":["Tianjin, China"]},{"name":"Tianjin University","place":["Tianjin, China"]},{"name":"Zhejiang Cancer Hospital","place":["Hangzhou, China"]},{"name":"Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences","place":["Hangzhou, China"]},{"name":"Key Laboratory of Prevention","place":["Hangzhou, China"]},{"name":"Diagnosis and Therapy of Gastrointestinal Cancer of Zhejiang Province","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ultrasound in Medicine and Engineering, School of Basic Medical Sciences, The Second Affiliated Hospital of Chongqing Medical University","place":["Chongqing, China"]},{"name":"Chongqing Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Li","sequence":"additional","affiliation":[{"name":"Zhejiang Cancer Hospital","place":["Hangzhou, China"]},{"name":"Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences","place":["Hangzhou, China"]},{"name":"Key Laboratory of Prevention","place":["Hangzhou, China"]},{"name":"Diagnosis and Therapy of Gastrointestinal Cancer of Zhejiang Province","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixing","family":"Huang","sequence":"additional","affiliation":[{"name":"Zhejiang Cancer Hospital","place":["Hangzhou, China"]},{"name":"Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences","place":["Hangzhou, China"]},{"name":"Zhejiang University School of Medicine","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Hu","sequence":"additional","affiliation":[{"name":"Zhejiang Cancer Hospital","place":["Hangzhou, China"]},{"name":"Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences","place":["Hangzhou, China"]},{"name":"Key Laboratory of Prevention","place":["Hangzhou, China"]},{"name":"Diagnosis and Therapy of Gastrointestinal Cancer of Zhejiang Province","place":["Hangzhou, China"]},{"name":"Zhejiang Provincial Research Centre for Upper Gastrointestinal Tract Cancer","place":["Hangzhou, China"]},{"name":"Zhejiang Cancer Hospital","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingcong","family":"Deng","sequence":"additional","affiliation":[{"name":"Zhejiang Cancer Hospital","place":["Hangzhou, China"]},{"name":"Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qimei","family":"Bao","sequence":"additional","affiliation":[{"name":"Zhejiang Cancer Hospital","place":["Hangzhou, China"]},{"name":"Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Shi","sequence":"additional","affiliation":[{"name":"Zhejiang University School of Medicine","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0846-7548","authenticated-orcid":true,"given":"Zu","family":"Ye","sequence":"additional","affiliation":[{"name":"Zhejiang Cancer Hospital","place":["Hangzhou, China"]},{"name":"Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences","place":["Hangzhou, China"]},{"name":"Key Laboratory of Prevention","place":["Hangzhou, China"]},{"name":"Diagnosis and Therapy of Gastrointestinal Cancer of Zhejiang Province","place":["Hangzhou, China"]},{"name":"Zhejiang Provincial Research Centre for Upper Gastrointestinal Tract Cancer","place":["Hangzhou, China"]},{"name":"Zhejiang Cancer Hospital","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5099-490X","authenticated-orcid":true,"given":"Xiangdong","family":"Cheng","sequence":"additional","affiliation":[{"name":"Zhejiang Cancer Hospital","place":["Hangzhou, China"]},{"name":"Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences","place":["Hangzhou, China"]},{"name":"Key Laboratory of Prevention","place":["Hangzhou, China"]},{"name":"Diagnosis and Therapy of Gastrointestinal Cancer of Zhejiang Province","place":["Hangzhou, China"]},{"name":"Zhejiang Provincial Research Centre for Upper Gastrointestinal Tract Cancer","place":["Hangzhou, China"]},{"name":"Zhejiang Cancer Hospital","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,10,29]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2024.1513426"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-024-05998-8"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1186\/s11658-024-00676-5"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.217412"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1340309"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.134187"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02887-6"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2008.01057.x"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.80324"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S472178"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.12851"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.9088247"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27462"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2020.104637"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c18134"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202107883"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c07973"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c18502"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S167043"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c11516"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.116364"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.08.050"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajps.2024.100993"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.112102"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2022.02.003"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.07.015"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1039\/C6NR01749E"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1007\/s40820-024-01536-9"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.34133\/bmr.0102"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2867-13-89"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25158423"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2024.03.005"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.7b00484"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-023-02118-4"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abl6432"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-023-01773-x"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S442877"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c22434"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-1278-1_17"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1007\/s11051-020-04798-7"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2024.105405"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.04.046"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28196783"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.15252\/msb.20166796"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2024.116731"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1754"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.07.029"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2024.04.012"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-0383-9"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231911890"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-08257-4"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1186\/s12896-024-00837-6"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00343"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.20517\/cdr.2022.136"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S479710"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201901372RR"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.01.201"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c07850"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S406649"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c11546"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1922270117"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.11.021"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.01.007"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-2298-2"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-024-02162-0"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1432520"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25126662"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-020-00462-0"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122869"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c19513"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1186\/s43556-024-00239-2"}],"container-title":["ACS Applied Materials & Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.5c13198","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.5c13198","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T09:50:40Z","timestamp":1762941040000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsami.5c13198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,29]]},"references-count":71,"journal-issue":{"issue":"45","published-print":{"date-parts":[[2025,11,12]]}},"alternative-id":["10.1021\/acsami.5c13198"],"URL":"https:\/\/doi.org\/10.1021\/acsami.5c13198","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,29]]}}}