{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:10:13Z","timestamp":1789585813220,"version":"build-2803163510"},"reference-count":46,"publisher":"American Chemical Society (ACS)","issue":"50","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Special Project for Clinical and Basic Sci&Tech Innovation of Guangdong Medical University","award":["GDMULCJC2024115"],"award-info":[{"award-number":["GDMULCJC2024115"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Appl. Mater. Interfaces"],"published-print":{"date-parts":[[2025,12,17]]},"DOI":"10.1021\/acsami.5c17806","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T18:44:44Z","timestamp":1764960284000},"page":"67581-67594","source":"Crossref","is-referenced-by-count":1,"title":["Oral Icariin Nanoparticles Ameliorate Nonalcoholic Fatty Liver Disease by Alleviating Oxidative Stress"],"prefix":"10.1021","volume":"17","author":[{"given":"Shilong","family":"Fan","sequence":"first","affiliation":[{"name":"The Affiliated Dongguan Songshan Lake Central Hospital","place":["Dongguan, PR China"]},{"name":"Guangdong Medical University","place":["Dongguan, PR China"]},{"name":"Key Laboratory of Human Microbiome and Chronic Diseases (Sun Yat-sen University)","place":["Guangzhou, PR China"]},{"name":"Ministry of Education","place":["Guangzhou, PR China"]},{"name":"Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital","place":["Guangzhou, PR China"]},{"name":"Sun Yat-sen University","place":["Guangzhou, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Ma","sequence":"additional","affiliation":[{"name":"Changji Vocational and Technical College","place":["Changji, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Li","sequence":"additional","affiliation":[{"name":"The Affiliated Dongguan Songshan Lake Central Hospital","place":["Dongguan, PR China"]},{"name":"Guangdong Medical University","place":["Dongguan, PR China"]},{"name":"School of Pharmacy","place":["Dongguan, PR China"]},{"name":"Guangdong Medical University","place":["Dongguan, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingqing","family":"Wang","sequence":"additional","affiliation":[{"name":"The Affiliated Dongguan Songshan Lake Central Hospital","place":["Dongguan, PR China"]},{"name":"Guangdong Medical University","place":["Dongguan, PR China"]},{"name":"School of Pharmacy","place":["Dongguan, PR China"]},{"name":"Guangdong Medical University","place":["Dongguan, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Pharmacy","place":["Dongguan, PR China"]},{"name":"Guangdong Medical University","place":["Dongguan, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinlian","family":"Yao","sequence":"additional","affiliation":[{"name":"School of Pharmacy","place":["Dongguan, PR China"]},{"name":"Guangdong Medical University","place":["Dongguan, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingxing","family":"Chai","sequence":"additional","affiliation":[{"name":"School of Pharmacy","place":["Dongguan, PR China"]},{"name":"Guangdong Medical University","place":["Dongguan, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9697-5897","authenticated-orcid":true,"given":"Zhikun","family":"Zhou","sequence":"additional","affiliation":[{"name":"The Affiliated Dongguan Songshan Lake Central Hospital","place":["Dongguan, PR China"]},{"name":"Guangdong Medical University","place":["Dongguan, PR China"]},{"name":"Changji Vocational and Technical College","place":["Changji, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,12,5]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-022-00980-1"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.50159"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13531"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10020174"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.595371"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.3390\/jfb14010044"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/bs.apha.2019.10.004"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23147519"},{"key":"ref9\/cit9","unstructured":"Development and Evaluation\nof Icariin-Loaded PLGA-PEG Nanoparticles\nfor Potentiation the Proapoptotic Activity in Pancreatic Cancer Cells\n- PubMed.\n                      . https:\/\/pubmed.ncbi.nlm.nih.gov\/34668089\/ (accessed 2025-10-29)."},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/4041415"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1007\/s12274-017-1918-3"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.3390\/polym13132208"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25031370"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12060590"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20701"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.01.194"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2018.10.006"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2021.1955550"},{"key":"ref19\/cit19","unstructured":"FTIR image showing PLGA \u2013 PEG \u2013 CD14\nencapsulation\nof miltefosine. | Download Scientific Diagram\n                      . https:\/\/www.researchgate.net\/figure\/FTIR-image-showing-PLGA-PEG-CD14-encapsulation-of-miltefosine_fig 1_283356783 (accessed 2025-10-29)."},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.03.026"},{"key":"ref21\/cit21","unstructured":"Infrared spectroscopy of flavones and flavonols.\nReexamination of\nthe hydroxyl and carbonyl vibrations in relation to the interactions\nof flavonoids with membrane lipids - ScienceDirect\n                      . https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S1386142517309678 (accessed 2025-10-29)."},{"key":"ref22\/cit22","doi-asserted-by":"publisher","unstructured":"D\u2019Souza, S. A Review of In Vitro Drug Release Test Methods for Nano-Sized Dosage Forms\n                      Advances in Pharmaceutics\n                      2014 10.1155\/2014\/304757","DOI":"10.1155\/2014\/304757"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241512510"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1039\/D3BM00802A"},{"key":"ref25\/cit25","doi-asserted-by":"crossref","unstructured":"Icariin Alleviates Nonalcoholic Fatty Liver Disease\nin Polycystic\nOvary Syndrome by Improving Liver Fatty Acid Oxidation and Inhibiting\nLipid Accumulation\n                      . https:\/\/www.mdpi.com\/1420-3049\/28\/2\/517 (accessed 2025-11-20).","DOI":"10.3390\/molecules28020517"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2025.113680"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1002\/mba2.65"},{"key":"ref28\/cit28","unstructured":"Thirty\nyears of NRF2: advances and therapeutic challenges - PubMed\n                      . https:\/\/pubmed.ncbi.nlm.nih.gov\/40038406\/ (accessed 2025-11-20)."},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12020403"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1134\/S0006297921110055"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2023.113841"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28020517"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1186\/s40779-022-00433-9"},{"key":"ref34\/cit34","unstructured":"Orally Deliverable Sequence-Targeted Fucoxanthin-Loaded Biomimetic\nExtracellular Vesicles for Alleviation of Nonalcoholic Fatty Liver\nDisease | ACS Applied Materials & Interfaces\n                      . https:\/\/pubs.acs.org\/doi\/10.1021\/acsami.3c18029 (accessed 2025-10-29)."},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b04315"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.06.016"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201807748"},{"key":"ref38\/cit38","unstructured":"Quantitative Structure\u2013Activity Relationship Enables the Rational\nDesign of Lipid Droplet-Targeting Carbon Dots for Visualizing Bisphenol\nA-Induced Nonalcoholic Fatty Liver Disease-like Changes | ACS Applied\nMaterials & Interfaces\n                      . https:\/\/pubs.acs.org\/doi\/10.1021\/acsami.1c13157 (accessed 2025-10-29)."},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c08240"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2020.108805"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c14674"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13070797"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2020.02.025"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13070797"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-804274-8.00028-X"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.156472"}],"container-title":["ACS Applied Materials & Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.5c17806","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.5c17806","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T10:14:04Z","timestamp":1765966444000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsami.5c17806"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,5]]},"references-count":46,"journal-issue":{"issue":"50","published-print":{"date-parts":[[2025,12,17]]}},"alternative-id":["10.1021\/acsami.5c17806"],"URL":"https:\/\/doi.org\/10.1021\/acsami.5c17806","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,5]]}}}