{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:23:25Z","timestamp":1791908605404,"version":"4.3.4"},"reference-count":33,"publisher":"American Chemical Society (ACS)","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22274089"],"award-info":[{"award-number":["22274089"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2022YQ10"],"award-info":[{"award-number":["ZR2022YQ10"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2023ZD44"],"award-info":[{"award-number":["ZR2023ZD44"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2024MB022"],"award-info":[{"award-number":["ZR2024MB022"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Project of Shandong Provincial Laboratory","award":["SYS202207"],"award-info":[{"award-number":["SYS202207"]}]},{"name":"Project of Shandong Provincial Center for Fundamental Science Research","award":["YDZX2024150"],"award-info":[{"award-number":["YDZX2024150"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Appl. Mater. Interfaces"],"DOI":"10.1021\/acsami.5c18781","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T09:39:22Z","timestamp":1767001162000},"source":"Crossref","is-referenced-by-count":2,"title":["Dual-Cascade Activated DNAzyme Nanoreactor within a Zn-Based MOF for Mitochondrial Gene Regulation"],"prefix":"10.1021","author":[{"given":"Xiuyan","family":"Wan","sequence":"first","affiliation":[{"name":"College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science","place":["Jinan, P. R. China"]},{"name":"Shandong Normal University","place":["Jinan, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukun","family":"Tao","sequence":"additional","affiliation":[{"name":"College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science","place":["Jinan, P. R. China"]},{"name":"Shandong Normal University","place":["Jinan, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingli","family":"Ge","sequence":"additional","affiliation":[{"name":"College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science","place":["Jinan, P. R. China"]},{"name":"Shandong Normal University","place":["Jinan, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2281-8749","authenticated-orcid":true,"given":"Wei","family":"Pan","sequence":"additional","affiliation":[{"name":"College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science","place":["Jinan, P. R. China"]},{"name":"Shandong Normal University","place":["Jinan, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3993-4778","authenticated-orcid":true,"given":"Peng","family":"Miao","sequence":"additional","affiliation":[{"name":"Shandong Laboratory of Advanced Biomaterials and Medical Devices in Weihai","place":["Weihai, P. R. China"]},{"name":"Suzhou Institute of Biomedical Engineering and Technology","place":["Suzhou, P. R. China"]},{"name":"Chinese Academy of Sciences","place":["Suzhou, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0392-6672","authenticated-orcid":true,"given":"Na","family":"Li","sequence":"additional","affiliation":[{"name":"College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science","place":["Jinan, P. R. China"]},{"name":"Shandong Normal University","place":["Jinan, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8712-7025","authenticated-orcid":true,"given":"Bo","family":"Tang","sequence":"additional","affiliation":[{"name":"College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science","place":["Jinan, P. R. China"]},{"name":"Shandong Normal University","place":["Jinan, P. R. China"]},{"name":"Laoshan Laboratory","place":["Qingdao, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,12,29]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.4251\/wjgo.v16.i3.761"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-024-00868-0"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5c05525"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-08668-x"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-024-01021-z"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(24)00247-4"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-024-00780-7"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.4c00332"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01780-w"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c05846"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202212277"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-024-01429-4"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-52968-1"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5c18947"},{"key":"ref15\/cit15","unstructured":"Li, Y. Early responding gene EGR1 mRNA noncoding molecules coordinate mitochondria functions through the hypoxia-mitophagy pathway in hepatocellular carcinoma cells; Ph.D. Thesis; Jilin University: Changchun, China, 2021."},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-021-00696-0"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1039\/D5TB00747J"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202409936"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202302495"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1039\/D4CC03774J"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.165386"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-2474"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2025.216720"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.3390\/molecules30051025"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.31635\/ccschem.021.202101418"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1039\/D3CS00386H"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c09536"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1039\/D3NR05776C"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1002\/cnma.202100389"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/ja805222x"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b01229"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2021.126255"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.7150\/thno.59593"}],"container-title":["ACS Applied Materials &amp; Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.5c18781","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.5c18781","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:59:02Z","timestamp":1768568342000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsami.5c18781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,29]]},"references-count":33,"alternative-id":["10.1021\/acsami.5c18781"],"URL":"https:\/\/doi.org\/10.1021\/acsami.5c18781","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,29]]},"article-number":"acsami.5c18781"}}