{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:13:46Z","timestamp":1790266426873,"version":"4.1.0"},"reference-count":56,"publisher":"American Chemical Society (ACS)","issue":"46","license":[{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100021856","name":"Ministero dell'Universit? e della Ricerca","doi-asserted-by":"publisher","award":["CUP I53C22000780001"],"award-info":[{"award-number":["CUP I53C22000780001"]}],"id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Appl. Mater. Interfaces"],"published-print":{"date-parts":[[2025,11,19]]},"DOI":"10.1021\/acsami.5c19638","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T18:45:24Z","timestamp":1762541124000},"page":"63286-63295","source":"Crossref","is-referenced-by-count":6,"title":["FLASH Radiotherapy Enhances the Therapeutic Ratio in an Embryonic In Vivo Model of Pancreatic Carcinoma"],"prefix":"10.1021","volume":"17","author":[{"given":"Noemi","family":"Giannini","sequence":"first","affiliation":[{"name":"Center for Nanotechnology Innovation@NEST\u2212Istituto Italiano di Tecnologia, Piazza San Silvestro 12, 56127 Pisa, Italy"},{"name":"Radiation Oncology Unit, Pisa University Hospital \u201cAzienda Ospedaliero-Universitaria Pisana\u201d, Via Roma 67, Pisa 56126, Italy"},{"name":"Department of Translational Research and New Technologies in Medicine and Surgery","place":["Pisa, Italy"]},{"name":"University of Pisa","place":["Pisa, Italy"]},{"name":"Centro Pisano Multidisciplinare Sulla Ricerca e Implementazione Clinica Della Flash Radiotherapy (CPFR)","place":["Pisa, Italy"]},{"name":"University of Pisa","place":["Pisa, Italy"]},{"name":"Center for Instrument Sharing of the University of Pisa (CISUP)","place":["Pisa, Italy"]},{"name":"University of Pisa","place":["Pisa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Gonnelli","sequence":"additional","affiliation":[{"name":"Center for Nanotechnology Innovation@NEST\u2212Istituto Italiano di Tecnologia, Piazza San Silvestro 12, 56127 Pisa, Italy"},{"name":"Radiation Oncology Unit, Pisa University Hospital \u201cAzienda Ospedaliero-Universitaria Pisana\u201d, Via Roma 67, Pisa 56126, Italy"},{"name":"Centro Pisano Multidisciplinare Sulla Ricerca e Implementazione Clinica Della Flash Radiotherapy (CPFR)","place":["Pisa, Italy"]},{"name":"University of Pisa","place":["Pisa, Italy"]},{"name":"Center for Instrument Sharing of the University of Pisa (CISUP)","place":["Pisa, Italy"]},{"name":"University of Pisa","place":["Pisa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Gadducci","sequence":"additional","affiliation":[{"name":"Center for Nanotechnology Innovation@NEST\u2212Istituto Italiano di Tecnologia, Piazza San Silvestro 12, 56127 Pisa, Italy"},{"name":"Radiation Oncology Unit, Pisa University Hospital \u201cAzienda Ospedaliero-Universitaria Pisana\u201d, Via Roma 67, Pisa 56126, Italy"},{"name":"Department of Translational Research and New Technologies in Medicine and Surgery","place":["Pisa, Italy"]},{"name":"University of Pisa","place":["Pisa, Italy"]},{"name":"Centro Pisano Multidisciplinare Sulla Ricerca e Implementazione Clinica Della Flash Radiotherapy (CPFR)","place":["Pisa, Italy"]},{"name":"University of Pisa","place":["Pisa, Italy"]},{"name":"Center for Instrument Sharing of the University of Pisa (CISUP)","place":["Pisa, Italy"]},{"name":"University of Pisa","place":["Pisa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Puccini","sequence":"additional","affiliation":[{"name":"Center for Nanotechnology Innovation@NEST\u2212Istituto Italiano di Tecnologia, Piazza San Silvestro 12, 56127 Pisa, Italy"},{"name":"Radiation Oncology Unit, Pisa University Hospital \u201cAzienda Ospedaliero-Universitaria Pisana\u201d, Via Roma 67, Pisa 56126, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Cavalieri","sequence":"additional","affiliation":[{"name":"Centro Pisano Multidisciplinare Sulla Ricerca e Implementazione Clinica Della Flash Radiotherapy (CPFR)","place":["Pisa, Italy"]},{"name":"University of Pisa","place":["Pisa, Italy"]},{"name":"Center for Instrument Sharing of the University of Pisa (CISUP)","place":["Pisa, Italy"]},{"name":"University of Pisa","place":["Pisa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Masturzo","sequence":"additional","affiliation":[{"name":"Centro Pisano Multidisciplinare Sulla Ricerca e Implementazione Clinica Della Flash Radiotherapy (CPFR)","place":["Pisa, Italy"]},{"name":"University of Pisa","place":["Pisa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jake Harold","family":"Pensavalle","sequence":"additional","affiliation":[{"name":"Centro Pisano Multidisciplinare Sulla Ricerca e Implementazione Clinica Della Flash Radiotherapy (CPFR)","place":["Pisa, Italy"]},{"name":"University of Pisa","place":["Pisa, Italy"]},{"name":"Sordina IORT Technologies S.p.A., Research and development","place":["Aprilia, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariagrazia","family":"Celentano","sequence":"additional","affiliation":[{"name":"Centro Pisano Multidisciplinare Sulla Ricerca e Implementazione Clinica Della Flash Radiotherapy (CPFR)","place":["Pisa, Italy"]},{"name":"University of Pisa","place":["Pisa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Di Martino","sequence":"additional","affiliation":[{"name":"Centro Pisano Multidisciplinare Sulla Ricerca e Implementazione Clinica Della Flash Radiotherapy (CPFR)","place":["Pisa, Italy"]},{"name":"University of Pisa","place":["Pisa, Italy"]},{"name":"Center for Instrument Sharing of the University of Pisa (CISUP)","place":["Pisa, Italy"]},{"name":"University of Pisa","place":["Pisa, Italy"]},{"name":"Unit of Medical Physics, Pisa University Hospital \u201cAzienda Ospedaliero-Universitaria Pisana\u201d, via Roma 67, Pisa 56126, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Di Cocco","sequence":"additional","affiliation":[{"name":"Division of Pathology, Department of Translational Research and New Technologies in Medicine and Surgery","place":["Pisa, Italy"]},{"name":"University of Pisa","place":["Pisa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Scatena","sequence":"additional","affiliation":[{"name":"Division of Pathology, Department of Translational Research and New Technologies in Medicine and Surgery","place":["Pisa, Italy"]},{"name":"University of Pisa","place":["Pisa, Italy"]},{"name":"Department of Oncology","place":["Pisa, Italy"]},{"name":"Pisa University Hospital","place":["Pisa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Giuseppe","family":"Naccarato","sequence":"additional","affiliation":[{"name":"Division of Pathology, Department of Translational Research and New Technologies in Medicine and Surgery","place":["Pisa, Italy"]},{"name":"University of Pisa","place":["Pisa, Italy"]},{"name":"Department of Oncology","place":["Pisa, Italy"]},{"name":"Pisa University Hospital","place":["Pisa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Menicagli","sequence":"additional","affiliation":[{"name":"Fondazione Pisana per la Scienza ONLUS, via Ferruccio Giovannini 13, S. Giuliano Terme, 56017 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Sarogni","sequence":"additional","affiliation":[{"name":"Center for Nanotechnology Innovation@NEST\u2212Istituto Italiano di Tecnologia, Piazza San Silvestro 12, 56127 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Frusca","sequence":"additional","affiliation":[{"name":"Center for Nanotechnology Innovation@NEST\u2212Istituto Italiano di Tecnologia, Piazza San Silvestro 12, 56127 Pisa, Italy"},{"name":"Scuola Superiore Sant\u2019Anna, Piazza Martiri della Libert\u00e0, 33, Pisa 56127, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dania","family":"Cioni","sequence":"additional","affiliation":[{"name":"Unit of Radiology, Pisa University Hospital \u201cAzienda Ospedaliero-Universitaria Pisana\u201d, via Roma 67, Pisa 56126, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni Donato","family":"Aquaro","sequence":"additional","affiliation":[{"name":"Unit of Radiology, Pisa University Hospital \u201cAzienda Ospedaliero-Universitaria Pisana\u201d, via Roma 67, Pisa 56126, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1311-3349","authenticated-orcid":true,"given":"Valerio","family":"Voliani","sequence":"additional","affiliation":[{"name":"Center for Nanotechnology Innovation@NEST\u2212Istituto Italiano di Tecnologia, Piazza San Silvestro 12, 56127 Pisa, Italy"},{"name":"Department of Pharmacy, School of Medical and Pharmaceutical Sciences, University of Genoa, Viale Cembrano 4, Genoa 16148, Italy"},{"name":"Centro 3R- Centro Interuniversitario per la promozione dei principi delle 3R nella didattica e nella ricerca","place":["Turin, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiola","family":"Paiar","sequence":"additional","affiliation":[{"name":"Radiation Oncology Unit, Pisa University Hospital \u201cAzienda Ospedaliero-Universitaria Pisana\u201d, Via Roma 67, Pisa 56126, Italy"},{"name":"Department of Translational Research and New Technologies in Medicine and Surgery","place":["Pisa, Italy"]},{"name":"University of Pisa","place":["Pisa, Italy"]},{"name":"Centro Pisano Multidisciplinare Sulla Ricerca e Implementazione Clinica Della Flash Radiotherapy (CPFR)","place":["Pisa, Italy"]},{"name":"University of Pisa","place":["Pisa, Italy"]},{"name":"Center for Instrument Sharing of the University of Pisa (CISUP)","place":["Pisa, Italy"]},{"name":"University of Pisa","place":["Pisa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,11,7]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.07.1754"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20180008"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2012.203"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.02.054"},{"key":"ref5\/cit5","unstructured":"World Cancer Research Fund. Pancreatic Cancer Statistics. https:\/\/www.wcrf.org\/preventing-cancer\/cancer-statistics\/pancreatic-cancer-statistics\/. (Accessed January 15, 2025)."},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i2.185"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.21037\/jgo.2015.10.01"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15133382"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.3390\/toxics11121011"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-015-0489-2"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1002\/mp.15442"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1373453"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3008973"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.3390\/cells13100835"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1901777116"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/S0146-6453(03)00021-6"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e14557"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1080\/21691401.2024.2309233"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/acsanm.3c05299"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c02567"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2021.1879047"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1002\/adbi.202200229"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.3389\/fphy.2023.1268310"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.3390\/ma17133355"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1002\/mp.15782"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmp.2022.08.010"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmp.2022.11.001"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.3389\/fphy.2020.570697"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.3389\/fphy.2025.1474416"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmp.2024.103360"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1002\/mp.17172"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1002\/mp.15668"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.sna.2025.116539"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.3390\/app13052986"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0155093"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1080\/00071660701261294"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1242\/dev.50.1.175"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1038\/nature08117"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401510208"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1177\/1536012118809585"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1007\/s10334-006-0062-y"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.12582"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199909000-00001"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.37429"},{"issue":"7","key":"ref45\/cit45","first-page":"869","volume":"46","author":"Wolpert L.","year":"2002","journal-title":"Int. J. Dev. Biol."},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-22-0262"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21626"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2020.1742931"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2008.03.004"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.02274"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16244260"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000000968"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-007-0277-z"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3131"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.8.2419"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.3389\/fphy.2020.570697"}],"container-title":["ACS Applied Materials &amp; Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.5c19638","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.5c19638","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T09:43:28Z","timestamp":1763545408000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsami.5c19638"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,7]]},"references-count":56,"journal-issue":{"issue":"46","published-print":{"date-parts":[[2025,11,19]]}},"alternative-id":["10.1021\/acsami.5c19638"],"URL":"https:\/\/doi.org\/10.1021\/acsami.5c19638","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,7]]}}}