{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T00:39:07Z","timestamp":1768610347335,"version":"3.49.0"},"reference-count":47,"publisher":"American Chemical Society (ACS)","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 114-2221-E-006-077-MY3"],"award-info":[{"award-number":["NSTC 114-2221-E-006-077-MY3"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 114-2622-E-006-026"],"award-info":[{"award-number":["NSTC 114-2622-E-006-026"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Appl. Mater. Interfaces"],"DOI":"10.1021\/acsami.5c20082","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:16:21Z","timestamp":1766189781000},"source":"Crossref","is-referenced-by-count":0,"title":["Augmenting Subunit-Vaccine-Induced Immunity through a Dual Strategy of Gold Nanoparticle Conjugation and Chitosan Microneedle-Mediated Sustained Delivery"],"prefix":"10.1021","author":[{"given":"Zih-Yao","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering","place":["Tainan, Taiwan"]},{"name":"National Cheng Kung University","place":["Tainan, Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Lun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering","place":["Tainan, Taiwan"]},{"name":"National Cheng Kung University","place":["Tainan, Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1331-2092","authenticated-orcid":true,"given":"Cheng-Lin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pathology, National Cheng Kung University Hospital, College of Medicine","place":["Tainan, Taiwan"]},{"name":"National Cheng Kung University","place":["Tainan, Taiwan"]},{"name":"Institute of Clinical Medicine, College of Medicine","place":["Tainan, Taiwan"]},{"name":"National Cheng Kung University","place":["Tainan, Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3524-629X","authenticated-orcid":true,"given":"Yu-Hung","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine","place":["Tainan, Taiwan"]},{"name":"National Cheng Kung University","place":["Tainan, Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2846-7537","authenticated-orcid":true,"given":"Mei-Chin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering","place":["Tainan, Taiwan"]},{"name":"National Cheng Kung University","place":["Tainan, Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.01.017"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.927306"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2023.01.006"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1298721"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.7150\/thno.84443"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2021.124088"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.03.034"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01745-z"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c01384"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-023-02022-x"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c10301"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202008352"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1021\/la9021799"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c05295"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/pj.2014.38"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2024.115481"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.04.024"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2018.03.007"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.05.015"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2024.102443"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13081132"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2023.122583"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120491"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.07.048"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2018.08.011"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2022.112897"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1039\/D3CS00138E"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1039\/C5TB00618J"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.157730"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2024.123051"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-025-01161-7"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpta.2024.100537"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.118050"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.3c01659"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.12.054"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01100"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c04671"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.8b03391"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S64353"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201901255"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2013.11.005"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2019.04.005"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.101653"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.2c00854"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202102180"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.08.054"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.4c01900"}],"container-title":["ACS Applied Materials & Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.5c20082","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.5c20082","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T13:11:51Z","timestamp":1768569111000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsami.5c20082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,19]]},"references-count":47,"alternative-id":["10.1021\/acsami.5c20082"],"URL":"https:\/\/doi.org\/10.1021\/acsami.5c20082","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,19]]},"article-number":"acsami.5c20082"}}