{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T10:21:14Z","timestamp":1765966874325,"version":"3.48.0"},"reference-count":68,"publisher":"American Chemical Society (ACS)","issue":"50","license":[{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100006441","name":"Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta","doi-asserted-by":"publisher","award":["RES0054712"],"award-info":[{"award-number":["RES0054712"]}],"id":[{"id":"10.13039\/501100006441","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Mitacs Elevated Program","award":["FR80630"],"award-info":[{"award-number":["FR80630"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Appl. Mater. Interfaces"],"published-print":{"date-parts":[[2025,12,17]]},"DOI":"10.1021\/acsami.5c20797","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T12:11:29Z","timestamp":1764677489000},"page":"68789-68801","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis and Characterization of Bisphosphonate-Functionalized Gadolinium Oxide Nanoparticles as Nonionizing Contrast Agents to Detect Bone Turnover"],"prefix":"10.1021","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6376-4474","authenticated-orcid":true,"given":"Adibehalsadat","family":"Ghazanfari","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy & Pharmaceutical Sciences","place":["Edmonton, Canada"]},{"name":"University of Alberta","place":["Edmonton, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy & Pharmaceutical Sciences","place":["Edmonton, Canada"]},{"name":"University of Alberta","place":["Edmonton, Canada"]},{"name":"Department of Chemical Engineering and Biochemistry","place":["Colima, Mexico"]},{"name":"Tecnol\u00f3gico Nacional de M\u00e9xico, Campus Colima","place":["Colima, Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Vega-Medina","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy & Pharmaceutical Sciences","place":["Edmonton, Canada"]},{"name":"University of Alberta","place":["Edmonton, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4535-1835","authenticated-orcid":true,"given":"Carlos A.","family":"Vel\u00e1zquez-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy & Pharmaceutical Sciences","place":["Edmonton, Canada"]},{"name":"University of Alberta","place":["Edmonton, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard B.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Faculty of Medicine & Dentistry","place":["Edmonton, Canada"]},{"name":"University of Alberta","place":["Edmonton, Canada"]},{"name":"Department of Radiology & Diagnostic Imaging, Faculty of Medicine & Dentistry","place":["Edmonton, Canada"]},{"name":"University of Alberta","place":["Edmonton, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob L.","family":"Jaremko","sequence":"additional","affiliation":[{"name":"Department of Radiology & Diagnostic Imaging, Faculty of Medicine & Dentistry","place":["Edmonton, Canada"]},{"name":"University of Alberta","place":["Edmonton, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neal M.","family":"Davies","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy & Pharmaceutical Sciences","place":["Edmonton, Canada"]},{"name":"University of Alberta","place":["Edmonton, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R.","family":"Doschak","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy & Pharmaceutical Sciences","place":["Edmonton, Canada"]},{"name":"University of Alberta","place":["Edmonton, Canada"]},{"name":"Department of Biomedical Engineering, Faculty of Medicine & Dentistry","place":["Edmonton, Canada"]},{"name":"University of Alberta","place":["Edmonton, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2025,12,2]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.1c00440"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1002\/EXP.20210089"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1186\/1477-3155-2-3"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2004.11.003"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S13816"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201300081"},{"key":"ref7\/cit7","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-84628-723-7","volume-title":"Fundamentals of Computerized Tomography: Image Reconstruction from Projections","author":"Herman G. T.","year":"2009"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.06.038"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1021\/cr200358s"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-022-02784-0"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1186\/s13244-024-01614-x"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2015.00256"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.bonr.2016.04.002"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2008.0028"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650020617"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1117\/1.JMI.11.6.066001"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-010-1766-x"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.141"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-54313-4"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmater.2025.100074"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-104-8_19"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/am4010495"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2010.10.007"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20807"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1186\/s13550-024-01137-y"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1039\/D3MA00231D"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201200032"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1002\/cmmi.1551"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/ar300150c"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.11.190"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1038\/srep08549"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.2174\/1568026611313040003"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1039\/C9RA08961F"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1039\/D3NA00105A"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.3390\/nano11092449"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1340"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/13169882"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1453"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.32311"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsusc.2017.11.225"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.3390\/polym14061259"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-007-0540-8"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.4065\/83.9.1032"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1039\/C4CP01946F"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2017.12.005"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1039\/C4NR03505D"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201800202"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.4061\/2010\/747852"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1039\/C9NA00401G"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1039\/C5GC00943J"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1080\/10426500307862"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2013.09.043"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2013.192"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1021\/nl0347334"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2019.05.033"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2005.02.089"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1021\/nn3046055"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202417548"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jchemed.3c00293"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.3390\/molecules30122519"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1021\/la0355702"},{"volume-title":"CRC Handbook of Chemistry and Physics: A Ready-Reference Book of Chemical and Physical Data","year":"2017","author":"Haynes W. M.","key":"ref62\/cit62"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1107\/S2052520624005080"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1002\/cmmi.1565"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S23940"},{"issue":"1","key":"ref66\/cit66","first-page":"3","volume":"14","author":"Riyahi-Alam S.","year":"2015","journal-title":"Iran J. Pharm. Res."},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0000000000000132"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.3390\/inorganics7050060"}],"container-title":["ACS Applied Materials &amp; Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.5c20797","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.5c20797","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T10:14:27Z","timestamp":1765966467000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsami.5c20797"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,2]]},"references-count":68,"journal-issue":{"issue":"50","published-print":{"date-parts":[[2025,12,17]]}},"alternative-id":["10.1021\/acsami.5c20797"],"URL":"https:\/\/doi.org\/10.1021\/acsami.5c20797","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"type":"print","value":"1944-8244"},{"type":"electronic","value":"1944-8252"}],"subject":[],"published":{"date-parts":[[2025,12,2]]}}}