{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:36:51Z","timestamp":1791923811393,"version":"4.3.4"},"reference-count":45,"publisher":"American Chemical Society (ACS)","license":[{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100012175","name":"Zhejiang Traditional Chinese Medicine Administration","doi-asserted-by":"publisher","award":["2023ZR001"],"award-info":[{"award-number":["2023ZR001"]}],"id":[{"id":"10.13039\/501100012175","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022963","name":"Key Research and Development Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2019C03024"],"award-info":[{"award-number":["2019C03024"]}],"id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014996","name":"Health Commission of Zhejiang Province","doi-asserted-by":"publisher","award":["2023RC130"],"award-info":[{"award-number":["2023RC130"]}],"id":[{"id":"10.13039\/501100014996","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014996","name":"Health Commission of Zhejiang Province","doi-asserted-by":"publisher","award":["WKJ-ZJ-1811"],"award-info":[{"award-number":["WKJ-ZJ-1811"]}],"id":[{"id":"10.13039\/501100014996","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Zhejiang Provincial People?s Hospital"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Appl. Mater. Interfaces"],"DOI":"10.1021\/acsami.5c22485","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T14:18:18Z","timestamp":1766499498000},"source":"Crossref","is-referenced-by-count":6,"title":["Epimedium-Derived Exosome-like Nanovesicles Regulate Lipid Metabolism via the \u201cGut\u2013Kidney Axis\u201d for Multitargeted Inhibition of Sepsis-Associated Acute Kidney Injury"],"prefix":"10.1021","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9186-8848","authenticated-orcid":true,"given":"Lan","family":"Yang","sequence":"first","affiliation":[{"name":"Emergency and Critical Care Center, Intensive Care Unit, Zhejiang Provincial People\u2019s Hospital (Affiliated People\u2019s Hospital)","place":["Hangzhou, China"]},{"name":"Hangzhou Medical College","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Hu","sequence":"additional","affiliation":[{"name":"Emergency and Critical Care Center, Intensive Care Unit, Zhejiang Provincial People\u2019s Hospital (Affiliated People\u2019s Hospital)","place":["Hangzhou, China"]},{"name":"Hangzhou Medical College","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3307-2264","authenticated-orcid":true,"given":"Liqiang","family":"Shao","sequence":"additional","affiliation":[{"name":"Emergency and Critical Care Center, Intensive Care Unit, Zhejiang Provincial People\u2019s Hospital (Affiliated People\u2019s Hospital)","place":["Hangzhou, China"]},{"name":"Hangzhou Medical College","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Tang","sequence":"additional","affiliation":[{"name":"Emergency and Critical Care Center, Intensive Care Unit, Zhejiang Provincial People\u2019s Hospital (Affiliated People\u2019s Hospital)","place":["Hangzhou, China"]},{"name":"Hangzhou Medical College","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangwei","family":"Yan","sequence":"additional","affiliation":[{"name":"Emergency and Critical Care Center, Intensive Care Unit, Zhejiang Provincial People\u2019s Hospital (Affiliated People\u2019s Hospital)","place":["Hangzhou, China"]},{"name":"Hangzhou Medical College","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengdie","family":"Yu","sequence":"additional","affiliation":[{"name":"Emergency and Critical Care Center, Intensive Care Unit, Zhejiang Provincial People\u2019s Hospital (Affiliated People\u2019s Hospital)","place":["Hangzhou, China"]},{"name":"Hangzhou Medical College","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gongning","family":"Chen","sequence":"additional","affiliation":[{"name":"Emergency and Critical Care Center, Intensive Care Unit, Zhejiang Provincial People\u2019s Hospital (Affiliated People\u2019s Hospital)","place":["Hangzhou, China"]},{"name":"Hangzhou Medical College","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6699-1195","authenticated-orcid":true,"given":"Yu","family":"Cai","sequence":"additional","affiliation":[{"name":"Emergency and Critical Care Center, Intensive Care Unit, Zhejiang Provincial People\u2019s Hospital (Affiliated People\u2019s Hospital)","place":["Hangzhou, China"]},{"name":"Hangzhou Medical College","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3234-1737","authenticated-orcid":true,"given":"Xiao-Zhou","family":"Mou","sequence":"additional","affiliation":[{"name":"Emergency and Critical Care Center, Intensive Care Unit, Zhejiang Provincial People\u2019s Hospital (Affiliated People\u2019s Hospital)","place":["Hangzhou, China"]},{"name":"Hangzhou Medical College","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianghong","family":"Yang","sequence":"additional","affiliation":[{"name":"Emergency and Critical Care Center, Intensive Care Unit, Zhejiang Provincial People\u2019s Hospital (Affiliated People\u2019s Hospital)","place":["Hangzhou, China"]},{"name":"Hangzhou Medical College","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,12,23]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-018-0052-0"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32989-7"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-010-2089-9"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2019.05.026"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-017-4755-7"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-023-00683-3"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00850122"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-050214-013407"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1172\/JCI152401"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32563-2"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k4891"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201604-0799OC"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1080\/21688370.2015.1134415"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2010.105"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27238184"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2018.10.001"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c19308"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c08573"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-0348-8012-1_1"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2011.01.001"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28207173"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202400846"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.03.007"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2025.119738"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1159\/000487955"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1002\/iid3.904"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109772"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-018-2363-x"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2022.107663"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-019-01083-1"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.1A0422-211R"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.117958"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.3402\/jev.v4.28713"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2008.01.006"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0165-0"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2025.102685"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-04794-w"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2024.122873"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116543"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2022.2084862"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2019.03.049"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-020-00732-4"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201400347"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119247"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.3390\/nu8040211"}],"container-title":["ACS Applied Materials & Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.5c22485","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.5c22485","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T13:11:24Z","timestamp":1768569084000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsami.5c22485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,23]]},"references-count":45,"alternative-id":["10.1021\/acsami.5c22485"],"URL":"https:\/\/doi.org\/10.1021\/acsami.5c22485","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,23]]},"article-number":"acsami.5c22485"}}