{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:57:42Z","timestamp":1787000262625,"version":"build-2736575974"},"reference-count":69,"publisher":"American Chemical Society (ACS)","license":[{"start":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:00Z","timestamp":1767139200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:00Z","timestamp":1767139200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:00Z","timestamp":1767139200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000928","name":"Welch Foundation","doi-asserted-by":"publisher","award":["C-2144"],"award-info":[{"award-number":["C-2144"]}],"id":[{"id":"10.13039\/100000928","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","award":["1R01AG077016"],"award-info":[{"award-number":["1R01AG077016"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000148","name":"National Science Foundation","doi-asserted-by":"publisher","award":["ECCS-1934977"],"award-info":[{"award-number":["ECCS-1934977"]}],"id":[{"id":"10.13039\/100000148","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000148","name":"National Science Foundation","doi-asserted-by":"publisher","award":["ECCS-2246564"],"award-info":[{"award-number":["ECCS-2246564"]}],"id":[{"id":"10.13039\/100000148","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Appl. Mater. Interfaces"],"DOI":"10.1021\/acsami.5c22623","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T10:51:16Z","timestamp":1767178276000},"source":"Crossref","is-referenced-by-count":1,"title":["Machine Learning-Enhanced Hyperspectral Raman Imaging for Label-Free Molecular Atlas of Alzheimer\u2019s Brain"],"prefix":"10.1021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1368-4539","authenticated-orcid":true,"given":"Ziyang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Electrical and Computer Engineering","place":["Houston, United States"]},{"name":"Rice University","place":["Houston, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeewan C.","family":"Ranasinghe","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering","place":["Houston, United States"]},{"name":"Rice University","place":["Houston, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis C. Y.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering","place":["University Park, United States"]},{"name":"The Pennsylvania State University","place":["University Park, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Gomm","sequence":"additional","affiliation":[{"name":"Genetics and Aging Research Unit, McCance Center for Brain Health, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital","place":["Charlestown, United States"]},{"name":"Harvard Medical School","place":["Charlestown, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolph E.","family":"Tanzi","sequence":"additional","affiliation":[{"name":"Genetics and Aging Research Unit, McCance Center for Brain Health, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital","place":["Charlestown, United States"]},{"name":"Harvard Medical School","place":["Charlestown, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4340-5118","authenticated-orcid":true,"given":"Can","family":"Zhang","sequence":"additional","affiliation":[{"name":"Genetics and Aging Research Unit, McCance Center for Brain Health, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital","place":["Charlestown, United States"]},{"name":"Harvard Medical School","place":["Charlestown, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanyin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering","place":["University Park, United States"]},{"name":"The Pennsylvania State University","place":["University Park, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3618-9074","authenticated-orcid":true,"given":"Shengxi","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering","place":["Houston, United States"]},{"name":"Rice University","place":["Houston, United States"]},{"name":"The Rice Advanced Materials Institute","place":["Houston, United States"]},{"name":"Rice University","place":["Houston, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,12,31]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abb3446"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-023-01112-y"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2023.09.006"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-024-07034-3"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32205-4"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.56"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)00070-3"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-020-00840-3"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.matchemphys.2024.129281"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1039\/d4nr01413h"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.3390\/bios13010027"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25235547"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c00538"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.8b00198"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1117\/12.552869"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.3390\/bios11100365"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2020.119188"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c16037"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2118836119"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/acsphotonics.2c00456"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","unstructured":"Jin, P.; Yeh, Y. T.; Ye, J.; Wang, Z.; Xue, Y.; Zhang, N.; Huang, S. X. S.; Ghedin, E.; Lu, H.; Schmitt, A.; Huang, S. X. S.; Terrones, M.\n                      Strain-Level Identification and Analysis of Avian Coronavirus Using Raman Spectroscopy and Interpretable Machine Learning\n                      , Proceedings - International Symposium on Biomedical Imaging, April 2023; pp 1\u20135 10.1109\/ISBI53787.2023.10230416.","DOI":"10.1109\/ISBI53787.2023.10230416"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-41417-0"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-024-02342-9"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-35696-2"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.7b00413"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.1c00289"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.3c00607"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1080\/05704928.2014.923902"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.17879\/freeneuropathology-2022-4210"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-210461"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1039\/D1AN01078F"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","unstructured":"Du, Z.; Nam, E.; Lin, Y.; Hong, M.; Moln\u00e1r, T.; Kondo, I.; Ishimori, K.; Baik, M.H.; Lee, Y.H.; Lim, M. H.Cytochrome c as a Distinct Modulator of Amyloid-b Amyloidogenesis in a Peroxide-Dependent Manner\n                      ChemRxiv\n                      2022, pp 1\u201320 10.26434\/chemrxiv-2022-3h55t.","DOI":"10.26434\/chemrxiv-2022-3h55t"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0042344"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00179"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-41645-4"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.107976"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.08.005"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1007\/s13205-022-03123-4"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-021-01249-0"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01484-7"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1002\/psc.2789"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13901-z"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.964336"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12202"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.4.1550"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12764"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.81475"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-022-00390-4"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008081"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25021173"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-015-1386-3"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt226"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16002-3"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1249018"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-019-0333-5"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12690"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-021-01599-x"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-02074-w"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-023-01314-6"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","unstructured":"Ibanez, L.; Liu, M.; Beric, A.; Timsina, J.; Kholfeld, P.; Bergmann, K.; Lowery, J.; Sykora, N.; Sanchez-Montejo, B.; Brock, W.; Budde, J. P.; Bateman, R. J.; Barthelemy, N.; Schindler, S. E.; Holtzman, D. M.; Benzinger, T. L. S.; Xiong, C.; Tarawneh, R.; Moulder, K.; Morris, J. C.; Sung, Y. J.; Cruchaga, C.Benchmarking of a Multi-Biomarker Low-Volume Panel for Alzheimer\u2019s Disease and Related Dementia Research\n                      medRxiv\n                      2024 10.1101\/2024.06.13.24308895.","DOI":"10.1101\/2024.06.13.24308895"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13164661"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-024-01273-4"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1038\/s41514-021-00064-9"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.690372"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.01176"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1126\/science.abm6131"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23179540"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-020-02441-x"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c05510"}],"container-title":["ACS Applied Materials &amp; Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.5c22623","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.5c22623","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:57:02Z","timestamp":1768568222000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsami.5c22623"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,31]]},"references-count":69,"alternative-id":["10.1021\/acsami.5c22623"],"URL":"https:\/\/doi.org\/10.1021\/acsami.5c22623","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,31]]},"article-number":"acsami.5c22623"}}