{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T04:59:34Z","timestamp":1792558774227,"version":"4.5.0"},"reference-count":43,"publisher":"American Chemical Society (ACS)","issue":"3","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"the Research Foundation of Peking University School and Hospital of Stomatology","award":["PKUSS202501012"],"award-info":[{"award-number":["PKUSS202501012"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Appl. Mater. Interfaces"],"published-print":{"date-parts":[[2026,1,28]]},"DOI":"10.1021\/acsami.5c23172","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T09:42:36Z","timestamp":1768556556000},"page":"5998-6017","source":"Crossref","is-referenced-by-count":5,"title":["IL-4\/Nanohydroxyapatite Codelivery in a Dual-Bionic Scaffold: Design and Immunomodulatory Endogenous Osteogenesis Mechanism"],"prefix":"10.1021","volume":"18","author":[{"given":"Feng-Ze","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery","place":["Beijing, P. R. China"]},{"name":"Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials","place":["Beijing, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery","place":["Beijing, P. R. China"]},{"name":"Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials","place":["Beijing, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Yuh","family":"Soh","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Faculty of Dentistry","place":["Kuala Lumpur, Malaysia"]},{"name":"University Kebangsaan Malaysia","place":["Kuala Lumpur, Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery","place":["Beijing, P. R. China"]},{"name":"Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials","place":["Beijing, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei-Hao","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of General Dentistry","place":["Beijing, P. R. China"]},{"name":"Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials","place":["Beijing, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zu-Nan","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery","place":["Beijing, P. R. China"]},{"name":"Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials","place":["Beijing, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Bo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery","place":["Beijing, P. R. China"]},{"name":"Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials","place":["Beijing, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8535-1771","authenticated-orcid":true,"given":"Xin","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery","place":["Beijing, P. R. China"]},{"name":"Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials","place":["Beijing, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,1,16]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.3390\/polym17070858"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202302818"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2010.09.010"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00654"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c22671"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.09.012"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.03.010"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201700801"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121538"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1039\/D3RA01700A"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121114"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-47189-5"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c17005"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2023.03.027"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123261"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c08996"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12907"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.201900123"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.3390\/polym14040669"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.168177"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2023.116956"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201801106"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202207089"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2022.120127"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2021.110109"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202403681"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201604617"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2025.06.001"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202414278"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202102236"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1038\/nri2395"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122992"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.xinn.2023.100542"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.130961"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202302539"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202507082"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231911025"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1007\/s42765-025-00596-9"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2023.02.025"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.4c01584"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.compositesa.2025.109205"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.05.007"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2025.117484"}],"container-title":["ACS Applied Materials & Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.5c23172","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.5c23172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T10:29:17Z","timestamp":1769596157000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsami.5c23172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,16]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,1,28]]}},"alternative-id":["10.1021\/acsami.5c23172"],"URL":"https:\/\/doi.org\/10.1021\/acsami.5c23172","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,16]]}}}