{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T14:39:14Z","timestamp":1776868754591,"version":"3.51.2"},"reference-count":34,"publisher":"American Chemical Society (ACS)","issue":"15","license":[{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100021856","name":"Ministero dell'Universit? e della Ricerca","doi-asserted-by":"publisher","award":["B93C22000920001"],"award-info":[{"award-number":["B93C22000920001"]}],"id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Appl. Mater. Interfaces"],"published-print":{"date-parts":[[2026,4,22]]},"DOI":"10.1021\/acsami.6c01637","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T23:34:17Z","timestamp":1775777657000},"page":"21749-21760","source":"Crossref","is-referenced-by-count":0,"title":["Leveraging MrkA Display on Self-Assembling Protein Nanoparticles for Enhanced Immune Activation"],"prefix":"10.1021","volume":"18","author":[{"given":"Valentina","family":"Monaci","sequence":"first","affiliation":[{"name":"Magnetic Resonance Center - CERM, University of Florence, Via Luigi Sacconi 6, Sesto Fiorentino, Florence 50019, Italy"},{"name":"Department of Chemistry, University of Florence, Via della Lastruccia 3, Sesto Fiorentino, Florence 50019, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Oldrini","sequence":"additional","affiliation":[{"name":"GSK Vaccines Institute for Global Health (GVGH), Via Fiorentina 1, Siena 53100, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiola","family":"Giusti","sequence":"additional","affiliation":[{"name":"GSK, Via Fiorentina 1, Siena 53100, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigia","family":"Cappelli","sequence":"additional","affiliation":[{"name":"GSK, Via Fiorentina 1, Siena 53100, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Cozzi","sequence":"additional","affiliation":[{"name":"GSK, Via Fiorentina 1, Siena 53100, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianina Florentina","family":"Belciug","sequence":"additional","affiliation":[{"name":"GSK Vaccines Institute for Global Health (GVGH), Via Fiorentina 1, Siena 53100, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Carducci","sequence":"additional","affiliation":[{"name":"GSK Vaccines Institute for Global Health (GVGH), Via Fiorentina 1, Siena 53100, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makrina","family":"Totsika","sequence":"additional","affiliation":[{"name":"GSK Vaccines Institute for Global Health (GVGH), Via Fiorentina 1, Siena 53100, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Rossi","sequence":"additional","affiliation":[{"name":"GSK Vaccines Institute for Global Health (GVGH), Via Fiorentina 1, Siena 53100, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Cantini","sequence":"additional","affiliation":[{"name":"Magnetic Resonance Center - CERM, University of Florence, Via Luigi Sacconi 6, Sesto Fiorentino, Florence 50019, Italy"},{"name":"Department of Chemistry, University of Florence, Via della Lastruccia 3, Sesto Fiorentino, Florence 50019, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8243-3181","authenticated-orcid":true,"given":"Francesca","family":"Micoli","sequence":"additional","affiliation":[{"name":"GSK Vaccines Institute for Global Health (GVGH), Via Fiorentina 1, Siena 53100, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5411-7667","authenticated-orcid":true,"given":"Gianmarco","family":"Gasperini","sequence":"additional","affiliation":[{"name":"GSK, Via Fiorentina 1, Siena 53100, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2025.125597"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2015.11.001"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-021-00330-7"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2013.11.069"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.73.10.3671"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.08.001"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-74949-2"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13101621"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1038\/nature12202"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c08379"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2018.05.034"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-69990-0"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1997.0970"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2833-4"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0896(01)00307-8"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2005.12.022"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/nature20108"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b02805"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0273322"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.890622"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/bm501066m"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.634349"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2024.02.072"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1080\/17425247.2023.2176844"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1099\/mgen.0.000800"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw021"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1002\/pro.70343"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2005.04.001"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0170529"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1007\/s12104-024-10185-3"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1039\/D5CB00320B"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-020-0719-0"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c14797"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1093\/bulcsj\/bcsj.20230224"}],"container-title":["ACS Applied Materials & Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.6c01637","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.6c01637","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T13:48:14Z","timestamp":1776865694000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsami.6c01637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,9]]},"references-count":34,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2026,4,22]]}},"alternative-id":["10.1021\/acsami.6c01637"],"URL":"https:\/\/doi.org\/10.1021\/acsami.6c01637","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,9]]}}}