{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:57:54Z","timestamp":1787000274041,"version":"build-2736575974"},"reference-count":48,"publisher":"American Chemical Society (ACS)","issue":"16","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100004761","name":"Natural Science Foundation of Hainan Province","doi-asserted-by":"publisher","award":["SQ2023MSXM0099"],"award-info":[{"award-number":["SQ2023MSXM0099"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014219","name":"National Science Fund for Distinguished Young Scholars","doi-asserted-by":"publisher","award":["82125026"],"award-info":[{"award-number":["82125026"]}],"id":[{"id":"10.13039\/501100014219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2025QC1717"],"award-info":[{"award-number":["ZR2025QC1717"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medicine Plus' Joint Research Program of Qingdao University","award":["YX2024201"],"award-info":[{"award-number":["YX2024201"]}]},{"name":"Hainan Provincial Clinical Medical Center Program"},{"DOI":"10.13039\/501100014761","name":"Qingdao Natural Science Foundation","doi-asserted-by":"crossref","award":["25-1-1-142-zyyd-jch"],"award-info":[{"award-number":["25-1-1-142-zyyd-jch"]}],"id":[{"id":"10.13039\/501100014761","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Youth Science Foundation of the Affiliated Hospital of Qingdao University","award":["QDFYQN2023109"],"award-info":[{"award-number":["QDFYQN2023109"]}]},{"name":"Youth Science Foundation of the Affiliated Hospital of Qingdao University","award":["QDFYQN2024106"],"award-info":[{"award-number":["QDFYQN2024106"]}]},{"name":"Key Program of National Natural Science Foundation of China","award":["82330081"],"award-info":[{"award-number":["82330081"]}]},{"name":"Innovative Research Projects for Postgraduate Students in Regular Higher Education Institutions of Hainan Province","award":["Qhyb2023-182"],"award-info":[{"award-number":["Qhyb2023-182"]}]},{"name":"\"Intergovernmental International Cooperation on Science and Technology Innovation\" National Key R&D Program of China","award":["2024YFE0104100"],"award-info":[{"award-number":["2024YFE0104100"]}]},{"name":"Taishan Scholars Program of Shandong Province","award":["Ts20190987"],"award-info":[{"award-number":["Ts20190987"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Appl. Mater. Interfaces"],"published-print":{"date-parts":[[2026,4,29]]},"DOI":"10.1021\/acsami.6c02122","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T12:53:25Z","timestamp":1776430405000},"page":"22889-22909","source":"Crossref","is-referenced-by-count":3,"title":["Temporally Programmed and Laser-Triggered Immunomodulatory Hydrogel Enables Synergistic Wound Healing and Prevention of Postoperative Tumor Recurrence"],"prefix":"10.1021","volume":"18","author":[{"given":"Shuo","family":"Shan","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Oncology Surgery","place":["Haikou, China"]},{"name":"The Second Affiliated Hospital of Hainan Medical University","place":["Haikou, China"]},{"name":"Tumor Immunology and Cytotherapy of Medical Research Center, Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases","place":["Qingdao, China"]},{"name":"The Affiliated Hospital of Qingdao University, Qingdao University","place":["Qingdao, China"]},{"name":"China Uruguay Bio-nano Pharmaceutical Joint Laboratory","place":["Qingdao, China"]},{"name":"Laboratory for Future Industry in Cytotherapy Immunity and Gene Editing at Higher Education Institutions in Shandong Province","place":["Qingdao, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunli","family":"Fu","sequence":"additional","affiliation":[{"name":"Tumor Immunology and Cytotherapy of Medical Research Center, Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases","place":["Qingdao, China"]},{"name":"The Affiliated Hospital of Qingdao University, Qingdao University","place":["Qingdao, China"]},{"name":"China Uruguay Bio-nano Pharmaceutical Joint Laboratory","place":["Qingdao, China"]},{"name":"Laboratory for Future Industry in Cytotherapy Immunity and Gene Editing at Higher Education Institutions in Shandong Province","place":["Qingdao, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Ma","sequence":"additional","affiliation":[{"name":"Tumor Immunology and Cytotherapy of Medical Research Center, Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases","place":["Qingdao, China"]},{"name":"The Affiliated Hospital of Qingdao University, Qingdao University","place":["Qingdao, China"]},{"name":"Department of Gastrointestinal Surgery","place":["Qingdao, China"]},{"name":"The Affiliated Hospital of Qingdao University","place":["Qingdao, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianghong","family":"L\u00fc","sequence":"additional","affiliation":[{"name":"Tumor Immunology and Cytotherapy of Medical Research Center, Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases","place":["Qingdao, China"]},{"name":"The Affiliated Hospital of Qingdao University, Qingdao University","place":["Qingdao, China"]},{"name":"Department of Gastrointestinal Surgery","place":["Qingdao, China"]},{"name":"The Affiliated Hospital of Qingdao University","place":["Qingdao, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Wang","sequence":"additional","affiliation":[{"name":"Tumor Immunology and Cytotherapy of Medical Research Center, Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases","place":["Qingdao, China"]},{"name":"The Affiliated Hospital of Qingdao University, Qingdao University","place":["Qingdao, China"]},{"name":"China Uruguay Bio-nano Pharmaceutical Joint Laboratory","place":["Qingdao, China"]},{"name":"Laboratory for Future Industry in Cytotherapy Immunity and Gene Editing at Higher Education Institutions in Shandong Province","place":["Qingdao, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering, College of Life Sciences","place":["Qingdao, China"]},{"name":"Qingdao University","place":["Qingdao, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Yu","sequence":"additional","affiliation":[{"name":"Tumor Immunology and Cytotherapy of Medical Research Center, Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases","place":["Qingdao, China"]},{"name":"The Affiliated Hospital of Qingdao University, Qingdao University","place":["Qingdao, China"]},{"name":"China Uruguay Bio-nano Pharmaceutical Joint Laboratory","place":["Qingdao, China"]},{"name":"Laboratory for Future Industry in Cytotherapy Immunity and Gene Editing at Higher Education Institutions in Shandong Province","place":["Qingdao, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haizhen","family":"Wang","sequence":"additional","affiliation":[{"name":"Tumor Immunology and Cytotherapy of Medical Research Center, Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases","place":["Qingdao, China"]},{"name":"The Affiliated Hospital of Qingdao University, Qingdao University","place":["Qingdao, China"]},{"name":"China Uruguay Bio-nano Pharmaceutical Joint Laboratory","place":["Qingdao, China"]},{"name":"Laboratory for Future Industry in Cytotherapy Immunity and Gene Editing at Higher Education Institutions in Shandong Province","place":["Qingdao, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Tumor Immunology and Cytotherapy of Medical Research Center, Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases","place":["Qingdao, China"]},{"name":"The Affiliated Hospital of Qingdao University, Qingdao University","place":["Qingdao, China"]},{"name":"China Uruguay Bio-nano Pharmaceutical Joint Laboratory","place":["Qingdao, China"]},{"name":"Laboratory for Future Industry in Cytotherapy Immunity and Gene Editing at Higher Education Institutions in Shandong Province","place":["Qingdao, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7795-2638","authenticated-orcid":true,"given":"Alvaro W.","family":"Mombr\u00fa","sequence":"additional","affiliation":[{"name":"Centro NanoMat & \u00c1rea F\u00edsica, Departamento de Experimentaci\u00f3n y Teor\u00eda de la Estructura de la Materia y sus Aplicaciones -DETEMA, Facultad de Qu\u00edmica","place":["Montevideo, Uruguay"]},{"name":"Universidad de la Rep\u00fablica","place":["Montevideo, Uruguay"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Mombr\u00fa","sequence":"additional","affiliation":[{"name":"Centro NanoMat & \u00c1rea F\u00edsica, Departamento de Experimentaci\u00f3n y Teor\u00eda de la Estructura de la Materia y sus Aplicaciones -DETEMA, Facultad de Qu\u00edmica","place":["Montevideo, Uruguay"]},{"name":"Universidad de la Rep\u00fablica","place":["Montevideo, Uruguay"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3529-2598","authenticated-orcid":true,"given":"Mariano","family":"Romero","sequence":"additional","affiliation":[{"name":"Centro NanoMat & \u00c1rea F\u00edsica, Departamento de Experimentaci\u00f3n y Teor\u00eda de la Estructura de la Materia y sus Aplicaciones -DETEMA, Facultad de Qu\u00edmica","place":["Montevideo, Uruguay"]},{"name":"Universidad de la Rep\u00fablica","place":["Montevideo, Uruguay"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Pardo","sequence":"additional","affiliation":[{"name":"Centro NanoMat & \u00c1rea F\u00edsica, Departamento de Experimentaci\u00f3n y Teor\u00eda de la Estructura de la Materia y sus Aplicaciones -DETEMA, Facultad de Qu\u00edmica","place":["Montevideo, Uruguay"]},{"name":"Universidad de la Rep\u00fablica","place":["Montevideo, Uruguay"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Gao","sequence":"additional","affiliation":[{"name":"Tumor Immunology and Cytotherapy of Medical Research Center, Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases","place":["Qingdao, China"]},{"name":"The Affiliated Hospital of Qingdao University, Qingdao University","place":["Qingdao, China"]},{"name":"China Uruguay Bio-nano Pharmaceutical Joint Laboratory","place":["Qingdao, China"]},{"name":"Laboratory for Future Industry in Cytotherapy Immunity and Gene Editing at Higher Education Institutions in Shandong Province","place":["Qingdao, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9528-0580","authenticated-orcid":true,"given":"He","family":"Ren","sequence":"additional","affiliation":[{"name":"Tumor Immunology and Cytotherapy of Medical Research Center, Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases","place":["Qingdao, China"]},{"name":"The Affiliated Hospital of Qingdao University, Qingdao University","place":["Qingdao, China"]},{"name":"China Uruguay Bio-nano Pharmaceutical Joint Laboratory","place":["Qingdao, China"]},{"name":"Laboratory for Future Industry in Cytotherapy Immunity and Gene Editing at Higher Education Institutions in Shandong Province","place":["Qingdao, China"]},{"name":"Gastrointestinal Cancer Institute (Pancreatic Disease Institute)","place":["Qingdao, China"]},{"name":"The Affiliated Hospital of Qingdao University","place":["Qingdao, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1903-0670","authenticated-orcid":true,"given":"Tiemin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology Surgery","place":["Haikou, China"]},{"name":"The Second Affiliated Hospital of Hainan Medical University","place":["Haikou, China"]},{"name":"Gastrointestinal Surgery","place":["Foshan, China"]},{"name":"Heyou Hospital","place":["Foshan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,4,17]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1007\/s44178-025-00152-w"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202309655"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-020-02454-z"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2023.113321"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115004"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2024.113996"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-023-00834-2"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2020.07.031"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.02538"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00534-x"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70263-3"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14184487"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol30030236"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1002\/mog2.70004"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.025"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-020-00991-2"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1111\/cas.14940"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuaa114"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.111119"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.3390\/polym13244291"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5c11952"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2023.11.066"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkac001"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-026-04219-2"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2020.02.011"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.02.021"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-2076"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.7150\/thno.92672"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2025.217772"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202305275"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-38014-6"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2025.217536"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5c00184"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202412191"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-020-0410-2"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c12532"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.143266"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2024.101232"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-021-01131-9"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.2c00500"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c17384"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2018.10.044"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.07.004"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.04.007"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1002\/mog2.67"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.20517\/microstructures.2024.135"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2023.11.005"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1007\/s12274-022-4877-4"}],"container-title":["ACS Applied Materials &amp; Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.6c02122","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.6c02122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:29:24Z","timestamp":1777458564000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsami.6c02122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,17]]},"references-count":48,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2026,4,29]]}},"alternative-id":["10.1021\/acsami.6c02122"],"URL":"https:\/\/doi.org\/10.1021\/acsami.6c02122","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,17]]}}}