{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T10:13:59Z","timestamp":1778062439904,"version":"3.51.4"},"reference-count":52,"publisher":"American Chemical Society (ACS)","issue":"17","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100013338","name":"Major Technology Innovation of Hubei Province","doi-asserted-by":"publisher","award":["2024BCA001"],"award-info":[{"award-number":["2024BCA001"]}],"id":[{"id":"10.13039\/501100013338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013338","name":"Major Technology Innovation of Hubei Province","doi-asserted-by":"publisher","award":["2025BCA006"],"award-info":[{"award-number":["2025BCA006"]}],"id":[{"id":"10.13039\/501100013338","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation of Wuhan City","award":["2024040701010046"],"award-info":[{"award-number":["2024040701010046"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China (NSFC)","doi-asserted-by":"crossref","award":["32401115"],"award-info":[{"award-number":["32401115"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Appl. Mater. Interfaces"],"published-print":{"date-parts":[[2026,5,6]]},"DOI":"10.1021\/acsami.6c02964","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T05:44:38Z","timestamp":1777009478000},"page":"24211-24223","source":"Crossref","is-referenced-by-count":0,"title":["Living Probiotic Microneedles Coordinate Antiandrogen and Nitric Oxide Therapy for Androgenetic Alopecia"],"prefix":"10.1021","volume":"18","author":[{"given":"Xuanxuan","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Key Laboratory of Industrial Biotechnology School of Life Sciences","place":["Wuhan, P. R. China"]},{"name":"Hubei University","place":["Wuhan, P. R. China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Key Laboratory of Industrial Biotechnology School of Life Sciences","place":["Wuhan, P. R. China"]},{"name":"Hubei University","place":["Wuhan, P. R. China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangsheng","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Xiangyang No.1 People\u2019s Hospital","place":["Xiangyang, China"]},{"name":"Hubei University of Medicine","place":["Xiangyang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengyi","family":"Zhan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Key Laboratory of Industrial Biotechnology School of Life Sciences","place":["Wuhan, P. R. China"]},{"name":"Hubei University","place":["Wuhan, P. R. China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Key Laboratory of Industrial Biotechnology School of Life Sciences","place":["Wuhan, P. R. China"]},{"name":"Hubei University","place":["Wuhan, P. R. China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenqian","family":"Ren","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Key Laboratory of Industrial Biotechnology School of Life Sciences","place":["Wuhan, P. R. China"]},{"name":"Hubei University","place":["Wuhan, P. R. China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Key Laboratory of Industrial Biotechnology School of Life Sciences","place":["Wuhan, P. R. China"]},{"name":"Hubei University","place":["Wuhan, P. R. China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4938-4741","authenticated-orcid":true,"given":"Lixin","family":"Ma","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Key Laboratory of Industrial Biotechnology School of Life Sciences","place":["Wuhan, P. R. China"]},{"name":"Hubei University","place":["Wuhan, P. R. China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Kuang","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Tongji Hospital, Tongji Medical College","place":["Wuhan, P. R. China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, P. R. China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6280-6910","authenticated-orcid":true,"given":"Huanhuan","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Key Laboratory of Industrial Biotechnology School of Life Sciences","place":["Wuhan, P. R. China"]},{"name":"Hubei University","place":["Wuhan, P. R. China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-016-0629-5"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.13079"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.08.018"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5c01739"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21155342"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111247"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2025.01.034"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-025-04420-4"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18356"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115913"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-025-03242-z"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.12.007"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2024.0284"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.11.002"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123627"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-020-01417-6"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1111\/ced.14292"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-024-02887-7"},{"key":"ref19\/cit19","first-page":"197","volume":"18","author":"Rosette C.","year":"2019","journal-title":"J. Drugs Dermatol."},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.3c01023"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202413108"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.101548"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b09417"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2003.11.018"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.3390\/foods14101763"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-025-03135-1"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-8-26"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201801210"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2023.09.021"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5c10174"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202503575"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2016.06.005"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14722"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202312088"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5c11155"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2025.01.003"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21030784"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba1685"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.156042"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.802336"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202500225"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1021\/acsmaterialslett.4c01891"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2025.1614090"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjy029"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.151888"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1021\/acsanm.5c01140"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2025.113597"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-024-03906-x"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.71863"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.17971"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.01114"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-12564-9"}],"container-title":["ACS Applied Materials &amp; Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.6c02964","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.6c02964","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T09:31:53Z","timestamp":1778059913000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsami.6c02964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,24]]},"references-count":52,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2026,5,6]]}},"alternative-id":["10.1021\/acsami.6c02964"],"URL":"https:\/\/doi.org\/10.1021\/acsami.6c02964","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,24]]}}}