{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:40:31Z","timestamp":1792604431759,"version":"4.5.0"},"reference-count":47,"publisher":"American Chemical Society (ACS)","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100012540","name":"Guangdong Provincial Introduction of Innovative Research and Development Team","doi-asserted-by":"publisher","award":["2017ZT07C291"],"award-info":[{"award-number":["2017ZT07C291"]}],"id":[{"id":"10.13039\/100012540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["KQTD20170810141424366"],"award-info":[{"award-number":["KQTD20170810141424366"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shenzhen Key Laboratory of Advanced Materials Project Engineering","award":["ZDSYS20190911164401990"],"award-info":[{"award-number":["ZDSYS20190911164401990"]}]},{"name":"University Development Fund","award":["UDF01001057"],"award-info":[{"award-number":["UDF01001057"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Oral ulcers are a common mucosal disorder that causes persistent pain and significantly impairs quality of life for patients. Current therapeutic approaches, including sprays and commercial patches, provide only temporary relief, as the complex, dynamic, and moist oral environment hinders prolonged retention and drug efficacy. Here, we report the rational design of a multifunctional hydrogel adhesive that integrates poly(acrylic acid) (PAA) for hydrogen bonding, polyamidoamine-epichlorohydrin (PAE) for electrostatic interactions with mucosal surfaces, and poly(methyl methacrylate) (PMMA) for swelling resistance. The resulting hydrogel exhibits an instant wet tissue adhesion strength of \u223c40 kPa and enhances adhesion after prolonged immersion in phosphate-buffered saline (PBS). Remarkably, it retains high adhesion strength under extreme conditions, such as hypertonic and strongly acidic environments. When loaded with dexamethasone acetate, the hydrogel enables controlled drug release, significantly improving therapeutic outcomes in a rat oral ulcer model. By ensuring prolonged retention and effective drug delivery, this hydrogel patch offers a promising strategy for enhancing oral ulcer treatment.<\/jats:p>","DOI":"10.1021\/acsami.6c05732","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:01:55Z","timestamp":1792602115000},"source":"Crossref","is-referenced-by-count":0,"title":["Wet-Adhesive Hydrogel Patch for Sustained Oral Ulcer Treatment"],"prefix":"10.1021","author":[{"given":"Yue","family":"Dong","sequence":"first","affiliation":[{"name":"The Chinese University of Hong Kong (Shenzhen) , , , ,","place":["Shenzhen, Guangdong, China, 518172"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengya","family":"Li","sequence":"additional","affiliation":[{"name":"Zhengzhou University , , ,","place":["Henan, China, 450001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyu","family":"Yang","sequence":"additional","affiliation":[{"name":"The Chinese University of Hong Kong (Shenzhen) , , , ,","place":["Shenzhen, Guangdong, China, 518172"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiwei","family":"Guo","sequence":"additional","affiliation":[{"name":"Wuhan Textile University , , ,","place":["Wuhan, China, 430200"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Zhengzhou University , , ,","place":["Henan, China, 450001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7731-6837","authenticated-orcid":true,"given":"He","family":"Zhu","sequence":"additional","affiliation":[{"name":"The Chinese University of Hong Kong (Shenzhen) , , , ,","place":["Shenzhen, Guangdong, China, 518172"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"issue":"3","key":"2026102113014343900_cit1","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1111\/j.1875-595X.2008.tb00185.x","article-title":"World Health Organization Global Policy for Improvement of Oral Health - World Health Assembly 2007","volume":"58","author":"Petersen","year":"2008","journal-title":"Int. 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Razi Inst."},{"issue":"4","key":"2026102113014343900_cit3","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/s00520-006-0171-1","article-title":"Comparing Pain Control and Ability to Eat and Drink with Standard Therapy vs Gelclair: A Preliminary, Double Centre, Randomised Controlled Trial on Patients with Radiotherapy-Induced Oral Mucositis","volume":"15","author":"Barber","year":"2007","journal-title":"Support Care Cancer"},{"key":"2026102113014343900_cit4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jconrel.2015.03.006","article-title":"Oral Films: Current Status and Future Perspectives","volume":"206","author":"Borges","year":"2015","journal-title":"J. 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Eng.: C"},{"issue":"46","key":"2026102113014343900_cit14","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202207741","article-title":"An Injectable Rapid-Adhesion and Anti-Swelling Adhesive Hydrogel for Hemostasis and Wound Sealing","volume":"32","author":"Bian","year":"2022","journal-title":"Adv. Funct. Mater."},{"issue":"2","key":"2026102113014343900_cit15","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1002\/app.31501","article-title":"The Effects of the pH Value of the Swelling Medium on the Kinetics of the Swelling of a Poly(Acrylic Acid) Hydrogel","volume":"116","author":"Jovanovic","year":"2010","journal-title":"J. Appl. Polym. Sci."},{"issue":"24","key":"2026102113014343900_cit16","doi-asserted-by":"publisher","first-page":"2803","DOI":"10.1002\/polb.21590","article-title":"Ionic and pH Effects on the Osmotic Properties and Structure of Polyelectrolyte Gels","volume":"46","author":"Horkay","year":"2008","journal-title":"J. Polym. Sci. B: Polym. 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Oral Sci."},{"issue":"2","key":"2026102113014343900_cit33","doi-asserted-by":"publisher","DOI":"10.3390\/gels7020069","article-title":"Neutralization and Salt Effect on the Structure and Mechanical Properties of Polyacrylic Acid Gels under Equivolume Conditions","volume":"7","author":"Tsuji","year":"2021","journal-title":"Gels"},{"key":"2026102113014343900_cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2023.105898","article-title":"Viscoelastic Behavior of Oral Mucosa. A Rheological Study Using Small-Amplitude Oscillatory Shear Tests","volume":"143","author":"Lacoste-Ferr\u00e9","year":"2023","journal-title":"J. Mech. Behav. Biomed. Mater."},{"issue":"3","key":"2026102113014343900_cit35","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.amjmed.2011.09.011","article-title":"Efficacy and Safety of Dexamethasone Ointment on Recurrent Aphthous Ulceration","volume":"125","author":"Liu","year":"2012","journal-title":"Am. J. 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Oral Invest."},{"issue":"1","key":"2026102113014343900_cit44","doi-asserted-by":"publisher","first-page":"7707","DOI":"10.1038\/s41467-023-43571-x","article-title":"A Self-Stabilized and Water-Responsive Deliverable Coenzyme-Based Polymer Binary Elastomer Adhesive Patch for Treating Oral Ulcer","volume":"14","author":"Cui","year":"2023","journal-title":"Nat. Commun."},{"key":"2026102113014343900_cit45","doi-asserted-by":"publisher","first-page":"e1038","DOI":"10.4317\/jced.58567","article-title":"Effects of Natural Extracts in the Treatment of Oral Ulcers: A Systematic Review of Evidence from Experimental Studies in Animals","author":"Wen","year":"2021","journal-title":"J. Clin. Exp. 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