{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T22:14:16Z","timestamp":1788473656440,"version":"build-2803163510"},"reference-count":66,"publisher":"American Chemical Society (ACS)","issue":"32","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Antibiotic resistance and oxidative stress-associated infections demand next-generation antimicrobial platforms that move beyond conventional drug mechanisms. Here, we present a nanozybiotic system comprising antibiotic-derived multienzyme-mimic carbon quantum dots co-doped with Cu\/Ru (Cu\/Ru-Moxi CDs). Engineered through a one-step hydrothermal approach, this platform incorporates a \u201cOne-Arrow-Three Hawks\u201d strategy: (i) the retention of intrinsic antibacterial activity from Moxifloxacin, (ii) the emergence of dual peroxidase- (POD)- and catalase (CAT)-like nanozyme activities, and (iii) a pH-dependent catalytic response for potential reactive oxygen species (ROS) modulation. Cu\/Ru-Moxi CDs exhibit strong POD- and CAT-like catalytic activity toward H2O2 (Km-TMB = 45.3 \u00b5M, Km-H2O2 = 555.3 \u00b5M). The nanozyme behavior further confers free-radical scavenging capability and pH-dependent POD- and CAT-like activity toward potential ROS modulation. The biological studies show retained antimicrobial activity against Gram-positive and Gram-negative bacteria, including multidrug-resistant MRSA, and even Mycobacterium tuberculosis (M. tuberculosis) (H37Rv\/H37Ra). The Cu\/Ru-Moxi CDs show enhanced biofilm inhibition against MRSA as compared to tested antibiotics. Moreover, the Cu\/Ru-Moxi CDs show good cytocompatibility with CC50 &amp;gt; 100 \u00b5g\/mL. The integration of precursor-derived antibiotic functionality with bimetallic catalytic centers, provides bactericidal action, dual nanozyme activity, and pH-dependent catalytic response, making Cu\/Ru-Moxi CDs a promising multifunctional nanozybiotic platform.<\/jats:p>","DOI":"10.1021\/acsami.6c05802","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T18:01:47Z","timestamp":1786125707000},"page":"43627-43645","source":"Crossref","is-referenced-by-count":0,"title":["One-Arrow-Three Hawks: Antibiotic-Derived Nanozybiotics with Retained Antibacterial Activity and Dual Peroxidase-\/Catalase-like Nanozyme for Potential ROS Modulation"],"prefix":"10.1021","volume":"18","author":[{"given":"Kaifi","family":"Ali","sequence":"first","affiliation":[{"name":"Indian Institute of Technology Jammu , , ,","place":["Jammu, India, 181221"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Gangwar","sequence":"additional","affiliation":[{"name":"CSIR-Indian Institute of Integrative Medicine , , ,","place":["Jammu, India, 180001"]},{"name":"Academy of Scientific and Innovative Research (AcSIR) , ,","place":["Ghaziabad, India, 201002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajan","family":"Patyal","sequence":"additional","affiliation":[{"name":"Indian Institute of Technology Jammu , , ,","place":["Jammu, India, 181221"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sathyaprakash","family":"Kumarasamy","sequence":"additional","affiliation":[{"name":"Indian Institute of Technology Jammu , , ,","place":["Jammu, India, 181221"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sapna","family":"Saini","sequence":"additional","affiliation":[{"name":"CSIR-Indian Institute of Integrative Medicine , , ,","place":["Jammu, India, 180001"]},{"name":"Academy of Scientific and Innovative Research (AcSIR) , ,","place":["Ghaziabad, India, 201002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi","family":"Sharma","sequence":"additional","affiliation":[{"name":"CSIR-Indian Institute of Integrative Medicine , , ,","place":["Jammu, India, 180001"]},{"name":"Academy of Scientific and Innovative Research (AcSIR) , ,","place":["Ghaziabad, India, 201002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7400-2867","authenticated-orcid":true,"given":"Vinay","family":"Sharma","sequence":"additional","affiliation":[{"name":"Indian Institute of Technology Jammu , , ,","place":["Jammu, India, 181221"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,7]]},"reference":[{"issue":"10369","key":"2026090317184322900_cit1","doi-asserted-by":"publisher","first-page":"2221","DOI":"10.1016\/S0140-6736(22)02185-7","article-title":"Global Mortality Associated with 33 Bacterial Pathogens in 2019: A Systematic Analysis for the Global Burden of Disease Study 2019","volume":"400","author":"Ikuta","year":"2022","journal-title":"Lancet"},{"issue":"3","key":"2026090317184322900_cit2","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/S1473-3099(17)30753-3","article-title":"Discovery, Research, and Development of New Antibiotics: The WHO Priority List of Antibiotic-Resistant Bacteria and Tuberculosis","volume":"18","author":"Tacconelli","year":"2018","journal-title":"Lancet Infect. 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