{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T16:10:56Z","timestamp":1788797456848,"version":"build-2803163510"},"reference-count":147,"publisher":"American Chemical Society (ACS)","issue":"28","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51803135"],"award-info":[{"award-number":["51803135"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270970"],"award-info":[{"award-number":["82270970"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470967"],"award-info":[{"award-number":["82470967"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Electrospun silk fibroin nanofibers (SFNFs) combine exceptional biocompatibility, tunable mechanical properties, and a native extracellular matrix (ECM)-mimetic architecture, making them compelling scaffolds for tissue engineering. Despite rapid progress, current research often pursues isolated material enhancements, lacking a cohesive strategy that aligns scaffold design with the complex biophysical and biochemical microenvironments of targeted tissues. To bridge this gap, this review presents a \u201cdesign-application coupling\u201d framework that systematically integrates SFNF composition, processing, and surface modifications with tissue-specific regenerative demands. Rather than exhaustively detailing basic manufacturing, we concisely distill advanced electrospinning modalities and targeted functionalization strategies\u2500such as inorganic reinforcement and immunomodulation\u2500that dictate mechanical robustness and bioactivity. Crucially, we map these engineered properties directly to their emerging clinical applications, comprehensively analyzing SFNF performance in the regeneration of bone, skeletal muscle, cardiovascular, neural, and skin tissues. Finally, we discuss critical challenges to clinical translation, including scalability and regulatory standardization, and propose future directions toward smart, bioresponsive materials. This framework provides a systematic pathway from bench-side innovation to bedside application, guiding the next generation of SFNF-based regenerative scaffolds.<\/jats:p>","DOI":"10.1021\/acsami.6c05865","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T04:11:48Z","timestamp":1783397508000},"page":"38299-38319","source":"Crossref","is-referenced-by-count":0,"title":["Design\nStrategies\nand Emerging Applications of Electrospun\nSilk Fibroin Nanofibers for Tissue Engineering"],"prefix":"10.1021","volume":"18","author":[{"given":"Xinyi","family":"He","sequence":"first","affiliation":[{"name":"Sichuan University , , , ,","place":["Chengdu, Sichuan, China, 610041"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuecheng","family":"Peng","sequence":"additional","affiliation":[{"name":"Sichuan University , , , ,","place":["Chengdu, Sichuan, China, 610065"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohan","family":"Wei","sequence":"additional","affiliation":[{"name":"Sichuan University , , , ,","place":["Chengdu, Sichuan, China, 610041"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9683-3506","authenticated-orcid":true,"given":"Xuefeng","family":"Hu","sequence":"additional","affiliation":[{"name":"Sichuan University , , , ,","place":["Chengdu, Sichuan, China, 610041"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengjie","family":"Lu","sequence":"additional","affiliation":[{"name":"Duke-National University of Singapore Medical School , , ,","place":["Singapore, Singapore, 169857"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7121-9817","authenticated-orcid":true,"given":"Kunneng","family":"Liang","sequence":"additional","affiliation":[{"name":"Sichuan University , , , ,","place":["Chengdu, Sichuan, China, 610041"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2827-3487","authenticated-orcid":true,"given":"Jieyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Sichuan University , , , ,","place":["Chengdu, Sichuan, China, 610065"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2412-6762","authenticated-orcid":true,"given":"Yunbing","family":"Wang","sequence":"additional","affiliation":[{"name":"Sichuan University , , , ,","place":["Chengdu, Sichuan, China, 610065"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,7]]},"reference":[{"key":"2026090711125345400_cit1","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.progpolymsci.2015.02.004","article-title":"Advancing biomaterials\nof human origin for tissue engineering","volume":"53","author":"Chen","year":"2016","journal-title":"Prog.\nPolym. Sci."},{"key":"2026090711125345400_cit2","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.bioactmat.2025.03.005","article-title":"A sequential drug delivery\nsystem based on silk fibroin scaffold for effective cartilage repair","volume":"49","author":"Xiao","year":"2025","journal-title":"Bioact. Mater."},{"key":"2026090711125345400_cit3","doi-asserted-by":"publisher","first-page":"119269","DOI":"10.1016\/j.carbpol.2022.119269","article-title":"Chitosan\/collagen\nlayer-by-layer\ndeposition for improving the esophageal regeneration ability of nanofibrous\nmats","volume":"286","author":"Qin","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"2026090711125345400_cit4","doi-asserted-by":"publisher","first-page":"102518","DOI":"10.1016\/j.mtbio.2025.102518","article-title":"Integrated biofabrication of artificial esophageal\nscaffolds using electrospinning, embedded DLP, and extrusion techniques","volume":"35","author":"Ranganathan","year":"2025","journal-title":"Mater. Today Bio"},{"key":"2026090711125345400_cit5","doi-asserted-by":"publisher","first-page":"2411256","DOI":"10.1002\/adma.202411256","article-title":"Silk Proteins: Designs\nfrom Nature with Multipurpose\nUtility and Infinite Future Possibilities","volume":"37","author":"Numata","year":"2025","journal-title":"Adv.\nMater."},{"issue":"1","key":"2026090711125345400_cit6","doi-asserted-by":"publisher","first-page":"4160","DOI":"10.1038\/s41467-024-48417-8","article-title":"Mechanically\nrobust and personalized silk fibroin-magnesium composite scaffolds\nwith water-responsive shape-memory for irregular bone regeneration","volume":"15","author":"Mao","year":"2024","journal-title":"Nat. Commun."},{"key":"2026090711125345400_cit7","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.bioactmat.2024.03.021","article-title":"Nanofiber-induced hierarchically-porous\nmagnesium phosphate bone\ncements accelerate bone regeneration by inhibiting Notch signaling","volume":"37","author":"Chen","year":"2024","journal-title":"Bioact. Mater."},{"issue":"1","key":"2026090711125345400_cit8","doi-asserted-by":"publisher","first-page":"3942","DOI":"10.1038\/s41598-024-54638-0","article-title":"Electrospun silk fibroin\/fibrin\nvascular scaffold with\nsuperior mechanical properties and biocompatibility for applications\nin tissue engineering","volume":"14","author":"Yang","year":"2024","journal-title":"Sci. Rep."},{"key":"2026090711125345400_cit9","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.progpolymsci.2015.02.001","article-title":"Structures, mechanical\nproperties and applications\nof silk fibroin materials","volume":"46","author":"Koh","year":"2015","journal-title":"Prog. Polym. Sci."},{"issue":"5","key":"2026090711125345400_cit10","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1016\/j.polymer.2004.11.029","article-title":"Regeneration of Bombyx\nmori silk by electrospinning. Part 3: characterization\nof electrospun nonwoven mat","volume":"46","author":"Ayutsede","year":"2005","journal-title":"Polymer"},{"issue":"23","key":"2026090711125345400_cit11","doi-asserted-by":"publisher","first-page":"3934","DOI":"10.1039\/C8TB00535D","article-title":"Fabrication of high\nperformance silk fibroin fibers via stable jet\nelectrospinning for potential use in anisotropic tissue regeneration","volume":"6","author":"Yi","year":"2018","journal-title":"J. Mater. Chem. B"},{"issue":"9","key":"2026090711125345400_cit12","doi-asserted-by":"publisher","first-page":"2107","DOI":"10.3390\/biomedicines10092107","article-title":"Multilayer Electrospun-Aligned\nFibroin\/Gelatin Implant for Annulus Fibrosus Repair: An In Vitro and\nIn Vivo Evaluation","volume":"10","author":"Hu","year":"2022","journal-title":"Biomedicines"},{"key":"2026090711125345400_cit13","doi-asserted-by":"publisher","first-page":"4991","DOI":"10.2147\/IJN.S248970","article-title":"Electrospun Scaffold with Sustained\nAntibacterial and\nTissue-Matched Mechanical Properties for Potential Application as\nFunctional Mesh","volume":"15","author":"Liu","year":"2020","journal-title":"Int. J. Nanomed."},{"issue":"9","key":"2026090711125345400_cit14","doi-asserted-by":"publisher","first-page":"2001646","DOI":"10.1002\/adhm.202001646","article-title":"Biomimetic\nSilk Fibroin Hydrogels Strengthened by Silica Nanoparticles Distributed\nNanofibers Facilitate Bone Repair","volume":"10","author":"Cheng","year":"2021","journal-title":"Adv. Healthcare\nMater."},{"key":"2026090711125345400_cit15","doi-asserted-by":"publisher","first-page":"100985","DOI":"10.1016\/j.mtbio.2024.100985","article-title":"Melatonin-encapsuled\nsilk fibroin electrospun nanofibers promote vascularized bone regeneration\nthrough regulation of osteogenesis-angiogenesis coupling","volume":"25","author":"Deng","year":"2024","journal-title":"Mater. Today Bio"},{"key":"2026090711125345400_cit16","doi-asserted-by":"publisher","first-page":"101273","DOI":"10.1016\/j.apmt.2021.101273","article-title":"Sandwich-like nanocomposite\nelectrospun silk fibroin membrane to promote osteogenesis and antibacterial\nactivities","volume":"26","author":"Xiang","year":"2022","journal-title":"Appl. Mater. Today"},{"key":"2026090711125345400_cit17","doi-asserted-by":"publisher","first-page":"130380","DOI":"10.1016\/j.ijbiomac.2024.130380","article-title":"Silk fibroin\/methacrylated\ngelatine\/hydroxyapatite biomimetic nanofibrous membranes for guided\nbone regeneration","volume":"263","author":"Li","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"16","key":"2026090711125345400_cit18","doi-asserted-by":"publisher","first-page":"4413","DOI":"10.1039\/D0BM00816H","article-title":"A novel knitted\nscaffold made of microfiber\/nanofiber core\u2013sheath\nyarns for tendon tissue engineering","volume":"8","author":"Cai","year":"2020","journal-title":"Biomater.\nSci."},{"key":"2026090711125345400_cit19","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.ijbiomac.2021.10.104","article-title":"Aligned silk\nfibroin\/poly-3-hydroxybutyrate\nnanofibrous scaffolds seeded with adipose-derived stem cells for tendon\ntissue engineering","volume":"193","author":"Sar\u0131kaya","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"2026090711125345400_cit20","doi-asserted-by":"publisher","first-page":"133905","DOI":"10.1016\/j.ijbiomac.2024.133905","article-title":"Electrospun\nhigh hydrophilicity antimicrobial poly (lactic acid)\/silk\nfibroin nanofiber membrane for wound dressings","volume":"277","author":"Fang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"15","key":"2026090711125345400_cit21","doi-asserted-by":"publisher","first-page":"5232","DOI":"10.1039\/D3BM00308F","article-title":"Silk fibroin-based\npiezoelectric nanofibrous scaffolds for rapid wound healing","volume":"11","author":"Yue","year":"2023","journal-title":"Biomater. Sci."},{"key":"2026090711125345400_cit22","doi-asserted-by":"publisher","first-page":"112666","DOI":"10.1016\/j.eurpolymj.2023.112666","article-title":"The silk fibroin nanofibrous membrane loaded with polyhexamethyl\nbiguanide for promoting infected wound healing","volume":"202","author":"Li","year":"2024","journal-title":"Eur. Polym. J."},{"issue":"36","key":"2026090711125345400_cit23","doi-asserted-by":"publisher","first-page":"42271","DOI":"10.1021\/acsami.3c08601","article-title":"Multifunctional Silk Fibroin\/Carbon Nanofiber Scaffolds for In Vitro\nCardiomyogenic Differentiation of Induced Pluripotent Stem Cells and\nEnergy Harvesting from Simulated Cardiac Motion","volume":"15","author":"Tufan","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"3","key":"2026090711125345400_cit24","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1016\/j.bioactmat.2020.04.005","article-title":"Improving mechanical and antibacterial properties of\nPMMA via polyblend electrospinning with silk fibroin and polyethyleneimine\ntowards dental applications","volume":"5","author":"Karatepe","year":"2020","journal-title":"Bioact. Mater."},{"issue":"3","key":"2026090711125345400_cit25","doi-asserted-by":"publisher","first-page":"2210764","DOI":"10.1002\/adfm.202210764","article-title":"Silk Fibroin as Sustainable\nAdvanced Material: Material Properties and Characteristics, Processing,\nand Applications","volume":"33","author":"Reizabal","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"2026090711125345400_cit26","doi-asserted-by":"publisher","first-page":"147360","DOI":"10.1016\/j.cej.2023.147360","article-title":"Accelerated\nbone defect repairment\nby carbon nitride photoelectric conversion material in core\u2013shell\nnanofibrous depended on neurogenesis","volume":"479","author":"Wang","year":"2024","journal-title":"Chem.\nEng. J."},{"issue":"5","key":"2026090711125345400_cit27","doi-asserted-by":"publisher","first-page":"2480","DOI":"10.1007\/s10924-025-03534-3","article-title":"Hybrid\nNano-Micro Scaffolds for Cartilage Tissue Engineering: Integrating\nPCL-DWJM-MWCNTs on Chemically Modified Silk Fibroin","volume":"33","author":"Zadehnajar","year":"2025","journal-title":"J. Polym. Environ."},{"key":"2026090711125345400_cit28","doi-asserted-by":"publisher","first-page":"158251","DOI":"10.1016\/j.cej.2024.158251","article-title":"Development of Silk Fibroin\/Gelatin\/PCL\ntri-polymeric\ncomplex nanofibrous two-dimensional mat for epithelial tissue regeneration","volume":"503","author":"Smita","year":"2025","journal-title":"Chem. Eng. J."},{"issue":"2","key":"2026090711125345400_cit29","doi-asserted-by":"publisher","first-page":"025002","DOI":"10.1088\/1758-5090\/acb106","article-title":"Constructing\nhigh-strength nano-micro fibrous woven scaffolds with native-like\nanisotropic structure and immunoregulatory function for tendon repair\nand regeneration","volume":"15","author":"Cai","year":"2023","journal-title":"Biofabrication"},{"key":"2026090711125345400_cit30","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.jcis.2021.02.099","article-title":"Silk fibroin H-fibroin\/poly(\u03b5-caprolactone)\ncore-shell nanofibers with enhanced mechanical property and long-term\ndrug release","volume":"593","author":"Wang","year":"2021","journal-title":"J. Colloid Interface Sci."},{"key":"2026090711125345400_cit31","doi-asserted-by":"publisher","first-page":"213246","DOI":"10.1016\/j.bioadv.2022.213246","article-title":"Mimicking\nbone matrix through coaxial electrospinning\nof core-shell nanofibrous scaffold for improving neurogenesis bone\nregeneration","volume":"145","author":"Wang","year":"2023","journal-title":"Biomater. Adv."},{"issue":"9","key":"2026090711125345400_cit32","doi-asserted-by":"publisher","first-page":"2384","DOI":"10.1039\/D3TB02911E","article-title":"Fabrication of a core\u2013shell nanofibrous wound dressing with\nan antioxidant effect on skin injury","volume":"12","author":"Feng","year":"2024","journal-title":"J. Mater.\nChem. B"},{"key":"2026090711125345400_cit33","doi-asserted-by":"publisher","first-page":"117058","DOI":"10.1016\/j.carbpol.2020.117058","article-title":"Chitosan\/polydopamine\nlayer by layer self-assembled silk fibroin\nnanofibers for biomedical applications","volume":"251","author":"Ma","year":"2021","journal-title":"Carbohydr.\nPolym."},{"key":"2026090711125345400_cit34","doi-asserted-by":"publisher","first-page":"110367","DOI":"10.1016\/j.nanoen.2024.110367","article-title":"Piezoelectric\nsilk fibroin nanofibers: Structural optimization\nto enhance piezoelectricity and biostability for neural tissue engineering","volume":"132","author":"Jin","year":"2024","journal-title":"Nano Energy"},{"issue":"7","key":"2026090711125345400_cit35","doi-asserted-by":"publisher","first-page":"2100388","DOI":"10.1002\/adbi.202100388","article-title":"Sugar Functionalization\nof Silks\nwith Pathway-Controlled Substitution and Properties","volume":"5","author":"Sahoo","year":"2021","journal-title":"Adv. Biol."},{"issue":"18","key":"2026090711125345400_cit36","doi-asserted-by":"publisher","first-page":"6322","DOI":"10.1016\/j.polymer.2006.07.009","article-title":"Preparation\nof non-woven mats from all-aqueous silk fibroin solution with electrospinning\nmethod","volume":"47","author":"Chen","year":"2006","journal-title":"Polymer"},{"issue":"4","key":"2026090711125345400_cit37","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1021\/bm4018319","article-title":"Rheology\nand Electrospinning\nof RegeneratedBombyx moriSilk Fibroin Aqueous Solutions","volume":"15","author":"Hodgkinson","year":"2014","journal-title":"Biomacromolecules"},{"issue":"5","key":"2026090711125345400_cit38","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1007\/s42765-025-00563-4","article-title":"Hierarchically Engineered Silk Fibroin\nNanotextiles with Spectral Selectivity and Asymmetric Nanostructure\nfor Sustainable Personal Thermal-Wet Regulation","volume":"7","author":"Li","year":"2025","journal-title":"Adv. Fiber Mater."},{"issue":"2","key":"2026090711125345400_cit39","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.ijbiomac.2010.12.008","article-title":"Preparation,\ncharacterization\nand biocompatibility of electrospinning heparin-modified silk fibroin\nnanofibers","volume":"48","author":"Wang","year":"2011","journal-title":"Int. J. Biol. Macromol."},{"issue":"15","key":"2026090711125345400_cit40","doi-asserted-by":"publisher","first-page":"3784","DOI":"10.1016\/j.biomaterials.2011.02.002","article-title":"Electrospun sulfated\nsilk fibroin nanofibrous scaffolds for vascular tissue engineering","volume":"32","author":"Liu","year":"2011","journal-title":"Biomaterials"},{"key":"2026090711125345400_cit41","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.actbio.2018.04.025","article-title":"Electrospun\nsilk fibroin fibers for storage and controlled\nrelease of human platelet lysate","volume":"73","author":"Pignatelli","year":"2018","journal-title":"Acta Biomater."},{"key":"2026090711125345400_cit42","doi-asserted-by":"publisher","first-page":"130955","DOI":"10.1016\/j.jhazmat.2023.130955","article-title":"Electrospun fluorinated\ncarbon nanotubes\/silk fibroin\ncomposite nanofibers for the analysis of perfluoroalkyl and polyfluoroalkyl\nsubstances","volume":"448","author":"Huang","year":"2023","journal-title":"J. Hazard. Mater."},{"issue":"2","key":"2026090711125345400_cit43","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.ijbiomac.2011.04.018","article-title":"Electrospun poly (\u03b5-caprolactone)\/silk\nfibroin core-sheath nanofibers and their potential applications in\ntissue engineering and drug release","volume":"49","author":"Li","year":"2011","journal-title":"Int. J.\nBiol. Macromol."},{"issue":"10","key":"2026090711125345400_cit44","doi-asserted-by":"publisher","first-page":"4019","DOI":"10.1016\/j.actbio.2010.05.008","article-title":"Compliant electrospun silk fibroin tubes for small\nvessel bypass grafting","volume":"6","author":"Marelli","year":"2010","journal-title":"Acta Biomater."},{"key":"2026090711125345400_cit45","doi-asserted-by":"publisher","first-page":"112260","DOI":"10.1016\/j.compositesb.2025.112260","article-title":"Silk fibroin electrospun\nscaffolds with sustained dual release of growth factors enhance acute\nliver failure treatment","volume":"296","author":"Liu","year":"2025","journal-title":"Composites, Part B"},{"key":"2026090711125345400_cit46","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.ijbiomac.2019.12.149","article-title":"Electrospun poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)\/silk\nfibroin film is a promising scaffold for bone tissue engineering","volume":"145","author":"Ang","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"issue":"5","key":"2026090711125345400_cit47","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/j.ijbiomac.2009.09.006","article-title":"A novel three-dimensional\ntubular scaffold prepared\nfrom silk fibroin by electrospinning","volume":"45","author":"Zhou","year":"2009","journal-title":"Int. J.\nBiol. Macromol."},{"issue":"4","key":"2026090711125345400_cit48","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.ijbiomac.2007.06.006","article-title":"Morphology\nand structure of electrospun\nmats from regenerated silk fibroin aqueous solutions with adjusting\npH","volume":"41","author":"Zhu","year":"2007","journal-title":"Int. J. Biol. Macromol."},{"key":"2026090711125345400_cit49","doi-asserted-by":"publisher","first-page":"113615","DOI":"10.1016\/j.jconrel.2025.113615","article-title":"Disulfiram-loaded\nelectrospun fibers\nwith antimicrobial and antitumoral properties for glioblastoma treatment","volume":"381","author":"Gonzalez-Prada","year":"2025","journal-title":"J. Controlled Release"},{"key":"2026090711125345400_cit50","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.carbpol.2016.05.088","article-title":"Carboxymethyl cellulose\nenables silk fibroin nanofibrous scaffold with enhanced biomimetic\npotential for bone tissue engineering application","volume":"151","author":"Singh","year":"2016","journal-title":"Carbohydr. Polym."},{"key":"2026090711125345400_cit51","doi-asserted-by":"publisher","first-page":"121008","DOI":"10.1016\/j.biomaterials.2021.121008","article-title":"Conductive polypyrrole-encapsulated\nsilk fibroin fibers for cardiac tissue engineering","volume":"276","author":"Liang","year":"2021","journal-title":"Biomaterials"},{"key":"2026090711125345400_cit52","doi-asserted-by":"publisher","first-page":"100243","DOI":"10.1016\/j.mtbio.2022.100243","article-title":"Electrospun\nstrong, bioactive, and bioabsorbable silk fibroin\/poly\n(L-lactic-acid) nanoyarns for constructing advanced nanotextile tissue\nscaffolds","volume":"14","author":"Liu","year":"2022","journal-title":"Mater. Today Bio"},{"issue":"2","key":"2026090711125345400_cit53","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1016\/j.actbio.2010.09.011","article-title":"Aligned natural\u2013synthetic polyblend nanofibers for peripheral\nnerve regeneration","volume":"7","author":"Wang","year":"2011","journal-title":"Acta Biomater."},{"key":"2026090711125345400_cit54","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.carbpol.2014.04.094","article-title":"Composite chitosan\/silk\nfibroin nanofibers for modulation of osteogenic differentiation and\nproliferation of human mesenchymal stem cells","volume":"111","author":"Lai","year":"2014","journal-title":"Carbohydr. Polym."},{"key":"2026090711125345400_cit55","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.ijbiomac.2020.06.045","article-title":"Corneal stromal regeneration by hybrid oriented poly\n(\u03b5-caprolactone)\/lyophilized silk fibroin electrospun scaffold","volume":"161","author":"Orash Mahmoud Salehi","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"2026090711125345400_cit56","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.ijbiomac.2018.03.072","article-title":"Nanofibrous silk fibroin\/reduced\ngraphene oxide scaffolds for tissue engineering and cell culture applications","volume":"114","author":"Nalvuran","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"2026090711125345400_cit57","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.carbpol.2019.01.047","article-title":"Layer-by-layer\nimmobilization of amphoteric carboxymethyl chitosan\nonto biocompatible silk fibroin nanofibrous mats","volume":"210","author":"Tu","year":"2019","journal-title":"Carbohydr. Polym."},{"issue":"4","key":"2026090711125345400_cit58","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/j.ijbiomac.2010.07.010","article-title":"Electrospinning of silk fibroin and\ncollagen for vascular tissue engineering","volume":"47","author":"Zhou","year":"2010","journal-title":"Int.\nJ. Biol. Macromol."},{"issue":"24","key":"2026090711125345400_cit59","doi-asserted-by":"publisher","first-page":"1801213","DOI":"10.1002\/adhm.201801213","article-title":"A Biodegradable\nStent with Surface Functionalization\nof Combined-Therapy Drugs for Colorectal Cancer","volume":"7","author":"Xie","year":"2018","journal-title":"Adv. Healthcare Mater."},{"key":"2026090711125345400_cit60","doi-asserted-by":"publisher","first-page":"127685","DOI":"10.1016\/j.ijbiomac.2023.127685","article-title":"Electrospun fibers\nbased anisotropic silk fibroin film with photodynamic antibacterial\ntherapy for S. aureus infected wound healing","volume":"254","author":"Li","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"5","key":"2026090711125345400_cit61","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1002\/mame.201200290","article-title":"Industrial\nUpscaling of Electrospinning and Applications of Polymer Nanofibers:\nA Review","volume":"298","author":"Persano","year":"2013","journal-title":"Macromol. Mater. Eng."},{"issue":"7","key":"2026090711125345400_cit62","doi-asserted-by":"publisher","first-page":"2414878","DOI":"10.1002\/adma.202414878","article-title":"An Efficient Biosynthetic\nSystem for Developing Functional Silk Fibroin-Based\nBiomaterials","volume":"37","author":"Wang","year":"2025","journal-title":"Adv. Mater."},{"key":"2026090711125345400_cit63","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1007\/s40883-024-00374-w","article-title":"Silk Fibroin\u2013Based\nBiomaterial Scaffold in Tissue Engineering: Present Persuasive Perspective","volume":"11","author":"Dutta","year":"2025","journal-title":"Regener. Eng. Transl. Med."},{"key":"2026090711125345400_cit64","doi-asserted-by":"publisher","first-page":"100381","DOI":"10.1016\/j.mtbio.2022.100381","article-title":"Bioinspired silk fibroin\nmaterials: From silk building blocks extraction and reconstruction\nto advanced biomedical applications","volume":"16","author":"Yao","year":"2022","journal-title":"Mater.\nToday Bio"},{"issue":"4","key":"2026090711125345400_cit65","doi-asserted-by":"publisher","first-page":"2357","DOI":"10.1021\/acsbiomaterials.0c00143","article-title":"Tough Anisotropic\nSilk Nanofiber Hydrogels with Osteoinductive\nCapacity","volume":"6","author":"Ding","year":"2020","journal-title":"ACS Biomater. Sci. Eng."},{"key":"2026090711125345400_cit66","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.03.339","article-title":"Fabrication and characterization\nof aligned graphene\/silk fibroin\nnanofibrous scaffolds for nerve tissue regeneration","volume":"259","author":"Yang","year":"2017","journal-title":"J. Controlled Release"},{"key":"2026090711125345400_cit67","doi-asserted-by":"publisher","first-page":"120056","DOI":"10.1016\/j.carbpol.2022.120056","article-title":"Chitosan\/silk\nfibroin biomimic scaffolds reinforced by cellulose acetate nanofibers\nfor smooth muscle tissue engineering","volume":"298","author":"Zhao","year":"2022","journal-title":"Carbohydr.\nPolym."},{"key":"2026090711125345400_cit68","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.jmst.2020.09.006","article-title":"Multi-functionalized nanofibers with reactive oxygen\nspecies scavenging\ncapability and fibrocartilage inductivity for tendon-bone integration","volume":"70","author":"Chen","year":"2021","journal-title":"J. Mater. Sci. Technol."},{"key":"2026090711125345400_cit69","doi-asserted-by":"publisher","first-page":"111147","DOI":"10.1016\/j.compositesb.2023.111147","article-title":"Electrospun photocrosslinkable hydrogel\nfibrous membrane with metal\nion trapping capability as an artificial periosteum to promote bone\nregeneration","volume":"271","author":"He","year":"2024","journal-title":"Composites, Part B"},{"issue":"25","key":"2026090711125345400_cit70","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adg0234","article-title":"Cooperative assembly of a designer peptide\nand silk fibroin into\nhybrid nanofiber gels for neural regeneration after spinal cord injury","volume":"9","author":"Feng","year":"2023","journal-title":"Sci. Adv."},{"key":"2026090711125345400_cit71","doi-asserted-by":"publisher","first-page":"124078","DOI":"10.1016\/j.ijbiomac.2023.124078","article-title":"Chitosan\/silk fibroin\/nitrogen-doped carbon quantum\ndot\/\u03b1-tricalcium phosphate nanocomposite electrospinned as a\nscaffold for wound healing application: In vitro and in vivo studies","volume":"238","author":"Dehghani","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"45","key":"2026090711125345400_cit72","doi-asserted-by":"publisher","first-page":"10407","DOI":"10.1039\/D0TB01962C","article-title":"A facile strategy\nto construct silk fibroin based GTR membranes with appropriate mechanical\nperformance and enhanced osteogenic capacity","volume":"8","author":"Zheng","year":"2020","journal-title":"J. Mater. Chem. B"},{"issue":"2","key":"2026090711125345400_cit73","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1007\/s42765-022-00252-6","article-title":"Double-Layer Nanofibrous Sponge Tube\nvia Electrospun Fiber and Yarn for Promoting Urethral Regeneration","volume":"5","author":"Zhang","year":"2023","journal-title":"Adv. Fiber Mater."},{"issue":"23","key":"2026090711125345400_cit74","doi-asserted-by":"publisher","first-page":"2000035","DOI":"10.1002\/adhm.202000035","article-title":"High Flexible\nand Broad Antibacterial Nanodressing Induces Complete Skin Repair\nwith Angiogenic and Follicle Regeneration","volume":"9","author":"Hu","year":"2020","journal-title":"Adv.\nHealthcare Mater."},{"key":"2026090711125345400_cit75","doi-asserted-by":"publisher","first-page":"108265","DOI":"10.1016\/j.matdes.2019.108265","article-title":"Accelerating\ndermal wound healing and mitigating excessive scar formation using\nLBL modified nanofibrous mats","volume":"185","author":"Wu","year":"2020","journal-title":"Mater. Des."},{"key":"2026090711125345400_cit76","doi-asserted-by":"publisher","first-page":"111622","DOI":"10.1016\/j.msec.2020.111622","article-title":"Co-electrospun\nnano-\/microfibrous composite scaffolds with structural and chemical\ngradients for bone tissue engineering","volume":"119","author":"Luo","year":"2021","journal-title":"Mater.\nSci. Eng. C"},{"issue":"15","key":"2026090711125345400_cit77","doi-asserted-by":"publisher","first-page":"8669","DOI":"10.1039\/D0CS00461H","article-title":"Inorganic\nnanomaterials with rapid clearance for biomedical applications","volume":"50","author":"Wang","year":"2021","journal-title":"Chem. Soc. Rev."},{"issue":"2","key":"2026090711125345400_cit78","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1021\/acsabm.3c00852","article-title":"Influence of Graphene-Based Nanocomposites in Neurogenesis and Neuritogenesis:\nA Brief Summary","volume":"7","author":"Raghavan","year":"2024","journal-title":"ACS Appl. Bio Mater."},{"key":"2026090711125345400_cit79","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.jmst.2022.10.031","article-title":"Biomimetic melatonin-loaded\nsilk fibroin\/GelMA scaffold\nstrengthens cartilage repair through retrieval of mitochondrial functions","volume":"146","author":"Hou","year":"2023","journal-title":"J. Mater. Sci. Technol."},{"key":"2026090711125345400_cit80","doi-asserted-by":"publisher","first-page":"135255","DOI":"10.1016\/j.cej.2022.135255","article-title":"Sponge-inspired\nsulfonated polyetheretherketone loaded with polydopamine-protected\nosthole nanoparticles and berberine enhances osteogenic activity and\nprevents implant-related infections","volume":"437","author":"Sang","year":"2022","journal-title":"Chem. Eng.\nJ."},{"issue":"1","key":"2026090711125345400_cit81","doi-asserted-by":"publisher","first-page":"2305215","DOI":"10.1002\/advs.202305215","article-title":"Natural Multifunctional\nSilk Microcarriers for Noise-Induced Hearing\nLoss Therapy","volume":"11","author":"Zhang","year":"2024","journal-title":"Adv. Sci."},{"key":"2026090711125345400_cit82","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.actbio.2016.12.008","article-title":"3D bioprinting of urethra\nwith PCL\/PLCL blend and dual autologous cells in fibrin hydrogel:\nAn in vitro evaluation of biomimetic mechanical property and cell\ngrowth environment","volume":"50","author":"Zhang","year":"2017","journal-title":"Acta Biomater."},{"key":"2026090711125345400_cit83","doi-asserted-by":"publisher","first-page":"216093","DOI":"10.1016\/j.ccr.2024.216093","article-title":"Biopolymer-based hydrogels for biomedical\napplications:\nBioactivity and wound healing properties","volume":"518","author":"Mehvari","year":"2024","journal-title":"Coord.\nChem. Rev."},{"key":"2026090711125345400_cit84","doi-asserted-by":"publisher","first-page":"116035","DOI":"10.1016\/j.biopha.2023.116035","article-title":"Enhancing\nangiogenesis: Innovative drug delivery systems\nto facilitate diabetic wound healing","volume":"170","author":"Wang","year":"2024","journal-title":"Biomed.\nPharmacother."},{"key":"2026090711125345400_cit85","doi-asserted-by":"publisher","first-page":"171596","DOI":"10.1016\/j.cej.2025.171596","article-title":"Construction\nof silk fibroin-based composite nanofiber films with effective antibacterial\nand filtration properties","volume":"527","author":"Wang","year":"2026","journal-title":"Chem. Eng. J."},{"issue":"3","key":"2026090711125345400_cit86","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1021\/acs.biomac.1c01430","article-title":"Magnolol Hybrid Nanofibrous\nMat with Antibacterial,\nAnti-Inflammatory, and Microvascularized Properties for Wound Treatment","volume":"23","author":"Liu","year":"2022","journal-title":"Biomacromolecules"},{"issue":"3","key":"2026090711125345400_cit87","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1039\/D0TB01747G","article-title":"PVA based nanofiber containing CQDs\nmodified with silica\nNPs and silk fibroin accelerates wound healing in a rat model","volume":"9","author":"Abolghasemzade","year":"2021","journal-title":"J. Mater. Chem. B"},{"issue":"7","key":"2026090711125345400_cit88","doi-asserted-by":"publisher","first-page":"3066","DOI":"10.1021\/acsbiomaterials.2c00103","article-title":"Nitric Oxide-Releasing Nanofibrous\nScaffolds Based on Silk Fibroin and Zein with Enhanced Biodegradability\nand Antibacterial Properties","volume":"8","author":"Ghalei","year":"2022","journal-title":"ACS Biomater.\nSci. Eng."},{"key":"2026090711125345400_cit89","doi-asserted-by":"publisher","first-page":"129927","DOI":"10.1016\/j.ijbiomac.2024.129927","article-title":"Janus silk fibroin\/polycaprolactone-based\nscaffold with directionally aligned fibers and porous structure for\nbone regeneration","volume":"262","author":"Tang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"14","key":"2026090711125345400_cit90","doi-asserted-by":"publisher","first-page":"1700014","DOI":"10.1002\/adhm.201700014","article-title":"Electrospun Nanofibrous Silk Fibroin\nMembranes Containing\nGelatin Nanospheres for Controlled Delivery of Biomolecules","volume":"6","author":"Song","year":"2017","journal-title":"Adv. Healthcare Mater."},{"issue":"10","key":"2026090711125345400_cit91","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1002\/adhm.201501066","article-title":"Pigmented Silk Nanofibrous Composite\nfor Skeletal Muscle Tissue Engineering","volume":"5","author":"Manchineella","year":"2016","journal-title":"Adv.\nHealthcare Mater."},{"issue":"48","key":"2026090711125345400_cit92","doi-asserted-by":"publisher","first-page":"65890","DOI":"10.1021\/acsami.4c14863","article-title":"A Multifunctional Bioadhesive\nfor Bone Augmentation: Tissue Integration Combined with Antioxidant\nand Antibacterial Effects","volume":"16","author":"Guo","year":"2024","journal-title":"ACS Appl. Mater.\nInterfaces"},{"key":"2026090711125345400_cit93","doi-asserted-by":"publisher","first-page":"111637","DOI":"10.1016\/j.colsurfb.2021.111637","article-title":"Gas foaming\nof electrospun poly(L-lactide-co-caprolactone)\/silk fibroin nanofiber\nscaffolds to promote cellular infiltration and tissue regeneration","volume":"201","author":"Chen","year":"2021","journal-title":"Colloids Surf., B"},{"key":"2026090711125345400_cit94","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.bioactmat.2023.12.019","article-title":"A tough, antibacterial and antioxidant hydrogel dressing\naccelerates wound healing and suppresses hypertrophic scar formation\nin infected wounds","volume":"34","author":"Liu","year":"2024","journal-title":"Bioact. Mater."},{"issue":"1","key":"2026090711125345400_cit96","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1007\/s42765-024-00451-3","article-title":"Fishnet-Inspired\n3D Scaffold Fabricated from Mesh-like Electrospun Membranes Promoted\nOsteoporotic Bone Regeneration","volume":"7","author":"Xiao","year":"2025","journal-title":"Adv. Fiber Mater."},{"key":"2026090711125345400_cit97","doi-asserted-by":"publisher","first-page":"134372","DOI":"10.1016\/j.ijbiomac.2024.134372","article-title":"Nanofibrous\ntextured silk aerogel with 3D channel arrays and adjustable mechanical\nproperties for bone tissue regeneration","volume":"278","author":"Long","year":"2024","journal-title":"Int.\nJ. Biol. Macromol."},{"key":"2026090711125345400_cit98","doi-asserted-by":"publisher","first-page":"123265","DOI":"10.1016\/j.ijbiomac.2023.123265","article-title":"Chitosan\/silk fibroin composite bilayer\nPCL nanofibrous mats for\nbone regeneration with enhanced antibacterial properties and improved\nosteogenic potential","volume":"230","author":"Wang","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"9","key":"2026090711125345400_cit99","doi-asserted-by":"publisher","first-page":"13702","DOI":"10.1021\/acsami.5c00874","article-title":"Silk Fibroin\nSurface\nEngineering Using Phase Separation Approaches for Enhanced Cell Adhesion\nand Proliferation","volume":"17","author":"Kocourkova\u0301","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"2","key":"2026090711125345400_cit100","doi-asserted-by":"publisher","first-page":"2402932","DOI":"10.1002\/adhm.202402932","article-title":"Engineering\nInjectable and Highly Interconnected Porous Silk Fibroin Microspheres\nfor Tissue Regeneration","volume":"14","author":"Ding","year":"2025","journal-title":"Adv. Healthcare Mater."},{"key":"2026090711125345400_cit101","doi-asserted-by":"publisher","first-page":"rbae117","DOI":"10.1093\/rb\/rbae117","article-title":"A facile nanopattern\nmodification of silk fibroin electrospun scaffold and the corresponding\nimpact on cell proliferation and osteogenesis","volume":"11","author":"Liu","year":"2024","journal-title":"Regener. Biomater."},{"issue":"7","key":"2026090711125345400_cit102","doi-asserted-by":"publisher","first-page":"5005","DOI":"10.1021\/am4060595","article-title":"Controlling the Cell\nAdhesion Property\nof Silk Films by Graft Polymerization","volume":"6","author":"Dhyani","year":"2014","journal-title":"ACS Appl.\nMater. Interfaces"},{"key":"2026090711125345400_cit103","doi-asserted-by":"publisher","first-page":"111095","DOI":"10.1016\/j.compositesb.2023.111095","article-title":"Asymmetric wettability fibrous membranes:\nPreparation and biologic applications","volume":"269","author":"Zhang","year":"2024","journal-title":"Composites,\nPart B"},{"key":"2026090711125345400_cit104","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1016\/j.ijbiomac.2021.05.026","article-title":"High-throughput fabrication\nof silk fibroin\/hydroxypropyl methylcellulose (SF\/HPMC) nanofibrous\nscaffolds for skin tissue engineering","volume":"183","author":"Yin","year":"2021","journal-title":"Int.\nJ. Biol. Macromol."},{"issue":"5","key":"2026090711125345400_cit105","doi-asserted-by":"publisher","first-page":"5526","DOI":"10.1016\/j.arabjc.2020.03.031","article-title":"Magnesium-containing silk fibroin\/polycaprolactone\nelectrospun nanofibrous\nscaffolds for accelerating bone regeneration","volume":"13","author":"Xing","year":"2020","journal-title":"Arabian J. Chem."},{"key":"2026090711125345400_cit106","doi-asserted-by":"publisher","first-page":"129308","DOI":"10.1016\/j.cej.2021.129308","article-title":"Fabrication of injectable hydrogels from silk fibroin and angiogenic\npeptides for vascular growth and tissue regeneration","volume":"418","author":"Wang","year":"2021","journal-title":"Chem. Eng. J."},{"key":"2026090711125345400_cit107","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.bioactmat.2023.02.002","article-title":"Dual-bionic regenerative\nmicroenvironment for peripheral\nnerve repair","volume":"26","author":"Guan","year":"2023","journal-title":"Bioact. Mater."},{"issue":"32","key":"2026090711125345400_cit108","doi-asserted-by":"publisher","first-page":"2000982","DOI":"10.1002\/adma.202000982","article-title":"Large-Scale\nFabrication of Robust Artificial Skins\nfrom a Biodegradable Sealant-Loaded Nanofiber Scaffold to Skin Tissue\nvia Microfluidic Blow-Spinning","volume":"32","author":"Cui","year":"2020","journal-title":"Adv. Mater."},{"key":"2026090711125345400_cit109","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.bioactmat.2023.08.004","article-title":"Multiphasic bone-ligament-bone integrated scaffold\nenhances ligamentization and graft-bone integration after anterior\ncruciate ligament reconstruction","volume":"31","author":"Xie","year":"2024","journal-title":"Bioact. Mater."},{"key":"2026090711125345400_cit110","doi-asserted-by":"publisher","first-page":"113039","DOI":"10.1016\/j.eurpolymj.2024.113039","article-title":"Silk fibroin incorporated\nelectrospun aliphatic polyester nanofiber scaffolds with excellent\ndimensional stability and cytocompatibility","volume":"211","author":"Gu","year":"2024","journal-title":"Eur. Polym. J."},{"key":"2026090711125345400_cit111","doi-asserted-by":"publisher","first-page":"110505","DOI":"10.1016\/j.compositesb.2023.110505","article-title":"Engineered periosteum-diaphysis\nsubstitutes with biomimetic structure\nand composition promote the repair of large segmental bone defects","volume":"252","author":"Yu","year":"2023","journal-title":"Composites, Part B"},{"issue":"21","key":"2026090711125345400_cit112","doi-asserted-by":"publisher","first-page":"2107714","DOI":"10.1002\/smll.202107714","article-title":"Co-Electrospun Silk\nFibroin and Gelatin Methacryloyl\nSheet Seeded with Mesenchymal Stem Cells for Tendon Regeneration","volume":"18","author":"Xue","year":"2022","journal-title":"Small"},{"key":"2026090711125345400_cit113","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.bioactmat.2023.03.023","article-title":"Cardiac patches made\nof brown adipose-derived stem cell sheets and conductive electrospun\nnanofibers restore infarcted heart for ischemic myocardial infarction","volume":"27","author":"Wei","year":"2023","journal-title":"Bioact. Mater."},{"key":"2026090711125345400_cit114","doi-asserted-by":"publisher","first-page":"213278","DOI":"10.1016\/j.bioadv.2023.213278","article-title":"Poly(ferulic\nacid)-hybrid nanofibers\nfor reducing thrombosis and restraining intimal hyperplasia in vascular\ntissue engineering","volume":"146","author":"Jin","year":"2023","journal-title":"Biomater. Adv."},{"key":"2026090711125345400_cit115","doi-asserted-by":"publisher","first-page":"100454","DOI":"10.1016\/j.mtbio.2022.100454","article-title":"A bionic multichannel nanofiber conduit carrying Tubastatin\nA for repairing injured spinal cord","volume":"17","author":"Liao","year":"2022","journal-title":"Mater.\nToday Bio"},{"key":"2026090711125345400_cit116","doi-asserted-by":"publisher","first-page":"154233","DOI":"10.1016\/j.cej.2024.154233","article-title":"Silk-fibroin-based nanofibrous\nscaffolds integrated with nano-engineered living bacteria enabling\nantibiotic-free accelerated infected wound healing","volume":"496","author":"Teng","year":"2024","journal-title":"Chem. Eng. J."},{"issue":"Pt B","key":"2026090711125345400_cit117","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.1016\/j.ijbiomac.2021.11.012","article-title":"Photoactive electrospun cellulose\nacetate\/polyethylene\noxide\/methylene blue and trilayered cellulose acetate\/polyethylene\noxide\/silk fibroin\/ciprofloxacin nanofibers for chronic wound healing","volume":"193","author":"Abdel Khalek","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"2026090711125345400_cit118","doi-asserted-by":"publisher","first-page":"100855","DOI":"10.1016\/j.mtbio.2023.100855","article-title":"Stem cells\nimplanted with nanofibrous mats for injured\nendometrial regeneration and immune-microenvironment remodeling","volume":"23","author":"Zhou","year":"2023","journal-title":"Mater. Today Bio"},{"key":"2026090711125345400_cit119","doi-asserted-by":"publisher","first-page":"109920","DOI":"10.1016\/j.compositesb.2022.109920","article-title":"Electrospun\nbiodegradable\nnanofibers loaded with epigallocatechin gallate for guided bone regeneration","volume":"238","author":"Song","year":"2022","journal-title":"Composites, Part B"},{"issue":"7","key":"2026090711125345400_cit120","doi-asserted-by":"publisher","first-page":"3294","DOI":"10.1007\/s10924-025-03598-1","article-title":"Harnessing\nthe Osteogenic Potential of Novel Copper Modified Baghdadite Nanogalleris\nIntegrated in Silk Fibroin Electrospun Scaffolds for Enhanced Bone\nRegeneration","volume":"33","author":"Khademolqorani","year":"2025","journal-title":"J. Polym. Environ."},{"issue":"14","key":"2026090711125345400_cit121","doi-asserted-by":"publisher","first-page":"2007946","DOI":"10.1002\/adma.202007946","article-title":"Functional\nSkeletal Muscle Regeneration with Thermally Drawn Porous Fibers and\nReprogrammed Muscle Progenitors for Volumetric Muscle Injury","volume":"33","author":"Jin","year":"2021","journal-title":"Adv. Mater."},{"key":"2026090711125345400_cit122","doi-asserted-by":"publisher","first-page":"102723","DOI":"10.1016\/j.apmt.2025.102723","article-title":"Tetrandrine-loaded\nelectrospun scaffold modulates\ninflammation and fibroblast activity to promote tendon regeneration","volume":"44","author":"Chen","year":"2025","journal-title":"Appl. Mater. Today"},{"issue":"9","key":"2026090711125345400_cit123","doi-asserted-by":"publisher","first-page":"6630","DOI":"10.1021\/acsabm.1c00654","article-title":"Bioactive Silk Fibroin-Based\nHybrid Biomaterials for Musculoskeletal\nEngineering: Recent Progress and Perspectives","volume":"4","author":"Wu","year":"2021","journal-title":"ACS Appl. Bio Mater."},{"issue":"3","key":"2026090711125345400_cit124","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1021\/acsbiomaterials.9b01682","article-title":"Solvent-Free Fabrication of Carbon Nanotube\/Silk Fibroin\nElectrospun Matrices for Enhancing Cardiomyocyte Functionalities","volume":"6","author":"Zhao","year":"2020","journal-title":"ACS Biomater. Sci. Eng."},{"key":"2026090711125345400_cit125","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.bioactmat.2023.03.023","article-title":"Cardiac patches made\nof brown adipose-derived stem cell sheets and conductive electrospun\nnanofibers restore infarcted heart for ischemic myocardial infarction","volume":"27","author":"Wei","year":"2023","journal-title":"Bioact. Mater."},{"key":"2026090711125345400_cit126","doi-asserted-by":"publisher","first-page":"7515","DOI":"10.2147\/IJN.S518283","article-title":"Circumferentially Aligned Electrospun Vascular Grafts\nImproves Its\nVascular Regeneration and Remodeling in vivo","volume":"20","author":"Xiong","year":"2025","journal-title":"Int. J. Nanomed."},{"issue":"3","key":"2026090711125345400_cit127","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1021\/acs.biomac.2c01383","article-title":"Controlled\nRelease of\nH2S from Biomimetic Silk Fibroin\u2013PLGA Multilayer Electrospun\nScaffolds","volume":"24","author":"Liguori","year":"2023","journal-title":"Biomacromolecules"},{"key":"2026090711125345400_cit128","doi-asserted-by":"publisher","first-page":"109301","DOI":"10.1016\/j.matdes.2020.109301","article-title":"Preliminary\napplication of a cell-free mono-layered vascular scaffold in a rabbit\nmodel","volume":"198","author":"Jin","year":"2021","journal-title":"Mater. Des."},{"key":"2026090711125345400_cit129","doi-asserted-by":"publisher","first-page":"213278","DOI":"10.1016\/j.bioadv.2023.213278","article-title":"Poly(ferulic acid)-hybrid nanofibers\nfor reducing thrombosis and restraining intimal hyperplasia in vascular\ntissue engineering","volume":"146","author":"Jin","year":"2023","journal-title":"Biomater. Adv."},{"key":"2026090711125345400_cit130","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.03.227","article-title":"A monodisperse microspheres\/silk\nfibroin nanofiber composite with controlled release of biomolecules\nfor vascular tissue engineering","volume":"259","author":"Liu","year":"2017","journal-title":"J. Controlled\nRelease"},{"issue":"1","key":"2026090711125345400_cit131","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/s41392-023-01477-6","article-title":"Spinal cord injury:\nmolecular mechanisms and therapeutic interventions","volume":"8","author":"Hu","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"key":"2026090711125345400_cit132","doi-asserted-by":"publisher","first-page":"19626","DOI":"10.1038\/srep19626","article-title":"an HDAC6 inhibitor, alleviates stroke-induced\nbrain infarction and functional deficits: potential roles of alpha-tubulin\nacetylation and FGF-21 up-regulation","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"key":"2026090711125345400_cit133","doi-asserted-by":"publisher","first-page":"100454","DOI":"10.1016\/j.mtbio.2022.100454","article-title":"A bionic\nmultichannel nanofiber conduit carrying Tubastatin\nA for repairing injured spinal cord","volume":"17","author":"Liao","year":"2022","journal-title":"Mater.\nToday Bio"},{"key":"2026090711125345400_cit134","doi-asserted-by":"publisher","first-page":"7469","DOI":"10.2147\/IJN.S521956","article-title":"Nano-Biomimetic\nFibronectin\/Lysostaphin-Co-Loaded\nSilk Fibroin Dressing Accelerates Full-Thickness Wound Healing via\nECM-Mimicking Microarchitecture and Dual-Function Modulation","volume":"20","author":"Liu","year":"2025","journal-title":"Int. J. Nanomed."},{"issue":"14","key":"2026090711125345400_cit135","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.3390\/cells12141827","article-title":"Human Keratinocytes\nand Fibroblasts Co-Cultured on Silk Fibroin Scaffolds Exosomally Overrelease\nAngiogenic and Growth Factors","volume":"12","author":"Hu","year":"2023","journal-title":"Cells"},{"key":"2026090711125345400_cit136","doi-asserted-by":"publisher","first-page":"111352","DOI":"10.1016\/j.colsurfb.2020.111352","article-title":"PLCL\/Silk fibroin based antibacterial nano wound dressing\nencapsulating oregano essential oil: Fabrication, characterization\nand biological evaluation","volume":"196","author":"Khan","year":"2020","journal-title":"Colloids Surf., B"},{"key":"2026090711125345400_cit137","doi-asserted-by":"publisher","first-page":"111557","DOI":"10.1016\/j.colsurfb.2021.111557","article-title":"Silk fibroin\/poly-(L-lactide-co-caprolactone)\nnanofiber scaffolds\nloaded with Huangbai Liniment to accelerate diabetic wound healing","volume":"199","author":"Xu","year":"2021","journal-title":"Colloids Surf., B"},{"issue":"20","key":"2026090711125345400_cit138","doi-asserted-by":"publisher","first-page":"5647","DOI":"10.1039\/D0BM00929F","article-title":"Sustained release of\ninhibitor from\nbionic scaffolds for wound healing and functional regeneration","volume":"8","author":"Yuan","year":"2020","journal-title":"Biomater. Sci."},{"issue":"18","key":"2026090711125345400_cit139","doi-asserted-by":"publisher","first-page":"2308833","DOI":"10.1002\/smll.202308833","article-title":"Protective\nTopical Dual-Sided Nanofibrous Hemostatic\nDressing Using Mussel and Silk Proteins with Multifunctionality of\nHemostasis and Anti-Bacterial Infiltration","volume":"20","author":"Lee","year":"2024","journal-title":"Small"},{"key":"2026090711125345400_cit140","doi-asserted-by":"publisher","first-page":"161989","DOI":"10.1016\/j.cej.2025.161989","article-title":"Tailored one-stop\ndressing\nfor diabetic wounds utilizing AIE electrospun photodynamic film","volume":"511","author":"Chang","year":"2025","journal-title":"Chem. Eng. J."},{"key":"2026090711125345400_cit141","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.ijbiomac.2021.04.021","article-title":"Electrospun PLGA\/SF\/artemisinin\ncomposite nanofibrous membranes for wound dressing","volume":"183","author":"Peng","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"2026090711125345400_cit142","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.1016\/j.ijbiomac.2021.11.012","article-title":"Photoactive electrospun cellulose\nacetate\/polyethylene\noxide\/methylene blue and trilayered cellulose acetate\/polyethylene\noxide\/silk fibroin\/ciprofloxacin nanofibers for chronic wound healing","volume":"193","author":"Abdel Khalek","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"2026090711125345400_cit143","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.jmst.2020.02.060","article-title":"Silk microfibrous\nmats with long-lasting antimicrobial function","volume":"63","author":"Wu","year":"2021","journal-title":"J. Mater. Sci. Technol."},{"key":"2026090711125345400_cit144","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.actbio.2023.04.015","article-title":"Aligned lovastatin-loaded\nelectrospun nanofibers regulate collagen organization and reduce scar\nformation","volume":"164","author":"Chen","year":"2023","journal-title":"Acta Biomater."},{"issue":"2","key":"2026090711125345400_cit145","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10268","article-title":"A biomimetic\nhyaluronic\nacid-silk fibroin nanofiber scaffold promoting regeneration of transected\nurothelium","volume":"7","author":"Niu","year":"2022","journal-title":"Bioeng. Transl. Med."},{"key":"2026090711125345400_cit146","doi-asserted-by":"publisher","first-page":"213648","DOI":"10.1016\/j.bioadv.2023.213648","article-title":"Development\nof dual-functional core-shell electrospun mats with controlled release\nof anti-inflammatory and anti-bacterial agents for the treatment of\ncorneal alkali burn injuries","volume":"154","author":"Razavi","year":"2023","journal-title":"Biomater. Adv."},{"key":"2026090711125345400_cit147","doi-asserted-by":"publisher","first-page":"111053","DOI":"10.1016\/j.matdes.2022.111053","article-title":"Multifunctional\nsilk fibroin \u2013 Poly(L-lactic acid) porous nanofibers: Designing\nadjustable nanopores to control composite properties and biological\nresponses","volume":"222","author":"Gu","year":"2022","journal-title":"Mater. Des."},{"key":"2026090711125345400_cit148","doi-asserted-by":"publisher","first-page":"100855","DOI":"10.1016\/j.mtbio.2023.100855","article-title":"Stem cells implanted with nanofibrous mats for injured\nendometrial regeneration and immune-microenvironment remodeling","volume":"23","author":"Zhou","year":"2023","journal-title":"Mater. Today Bio"}],"container-title":["ACS Applied Materials &amp;\nInterfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.6c05865","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/aamick\/article-pdf\/18\/28\/38299\/65803246\/acsami.6c05865.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/aamick\/article-pdf\/18\/28\/38299\/65803246\/acsami.6c05865.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T15:43:27Z","timestamp":1788795807000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/aamick\/article\/18\/28\/38299\/5201993\/Design-Strategies-and-Emerging-Applications-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,7]]},"references-count":147,"journal-issue":{"issue":"28","published-online":{"date-parts":[[2026,7,7]]},"published-print":{"date-parts":[[2026,7,22]]}},"URL":"https:\/\/doi.org\/10.1021\/acsami.6c05865","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,7]]}}}