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Macromolecular nucleic acid drugs such as siRNA have potential because of their high specificity. However, their clinical application has been hindered by the physical barrier of the stratum corneum. This study reports a hybrid nanoplatform based on cationic ionic liquid liposomes (ITD) that achieves efficient transdermal delivery of an asymmetric siRNA (asiRNA) targeting AR. This platform (particle size \u223c200 nm, zeta potential +15 mV) leverages the penetration-enhancing properties of ionic liquids to improve asiRNA transdermal efficiency 8-fold and demonstrates an in vitro AR silencing efficacy comparable to that of the commercial gold-standard reagent. By silencing AR (a central androgen-responsive regulatory node shared by pilosebaceous disorders) in murine models, the formulation attenuates androgen-induced hair loss, alleviates acne-like inflammatory lesions, and reduces sebum-associated lipid accumulation. Remarkably, this preclinical pleiotropy is translated into preliminary open-label human efficacy evaluation: in a volunteer study, the formulation significantly reduced hair loss counts (\u221248.59%), inflammatory acne lesions (\u221267.74%), and skin sebum levels (\u221224.92%). In summary, the ITD platform represents a novel, noninvasive therapeutic strategy that addresses multiple recalcitrant androgen-dependent dermatoses, demonstrating clinical translational potential.<\/jats:p>","DOI":"10.1021\/acsami.6c05877","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T09:02:03Z","timestamp":1786611723000},"page":"45449-45467","source":"Crossref","is-referenced-by-count":0,"title":["A Cationic Ionic Liquid\u2212Liposome Nanoplatform Enables Transdermal asiRNA Delivery for Androgen-Dependent Dermatoses"],"prefix":"10.1021","volume":"18","author":[{"given":"Mingqing","family":"Zhou","sequence":"first","affiliation":[{"name":"Northeastern University , , ,","place":["Shenyang, China, 110819"]},{"name":"Harbin Institute of Technology , , ,","place":["Shenzhen, China, 518055"]},{"name":"Shenzhen Shinehigh, Innovation Technology Co., Ltd. , ,","place":["Shenzhen, China, 518055"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Tang","sequence":"additional","affiliation":[{"name":"Harbin Institute of Technology , , ,","place":["Shenzhen, China, 518055"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haowei","family":"Chen","sequence":"additional","affiliation":[{"name":"DingMa Geili (Beijing) Biotechnology Co., Ltd , ,","place":["Beijing, China, 101318"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianqi","family":"Liu","sequence":"additional","affiliation":[{"name":"Harbin Institute of Technology , , ,","place":["Shenzhen, China, 518055"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Northeastern University , , ,","place":["Shenyang, China, 110819"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Tan","sequence":"additional","affiliation":[{"name":"DingMa Geili (Beijing) Biotechnology Co., Ltd , ,","place":["Beijing, China, 101318"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanxi","family":"Xiang","sequence":"additional","affiliation":[{"name":"Harbin Institute of Technology , , ,","place":["Shenzhen, China, 518055"]},{"name":"Chongqing Innovation Center of Beijing Institute of Technology , ,","place":["Chongqing, China, 401120"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Ruan","sequence":"additional","affiliation":[{"name":"Shenzhen Shinehigh, Innovation Technology Co., Ltd. , ,","place":["Shenzhen, China, 518055"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Yang","sequence":"additional","affiliation":[{"name":"Shenzhen Shinehigh, Innovation Technology Co., Ltd. , ,","place":["Shenzhen, China, 518055"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jichuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Harbin Institute of Technology , , ,","place":["Shenzhen, China, 518055"]},{"name":"Shenzhen Shinehigh, Innovation Technology Co., Ltd. , ,","place":["Shenzhen, China, 518055"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Shenzhen Shinehigh, Innovation Technology Co., Ltd. , ,","place":["Shenzhen, China, 518055"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1596-5943","authenticated-orcid":true,"given":"Yang","family":"Shu","sequence":"additional","affiliation":[{"name":"Northeastern University , , ,","place":["Shenyang, China, 110819"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Wang","sequence":"additional","affiliation":[{"name":"DingMa Geili (Beijing) Biotechnology Co., Ltd , ,","place":["Beijing, China, 101318"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2377-9796","authenticated-orcid":true,"given":"Jiaheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Harbin Institute of Technology , , ,","place":["Shenzhen, China, 518055"]},{"name":"Shenzhen Shinehigh, Innovation Technology Co., Ltd. , ,","place":["Shenzhen, China, 518055"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"issue":"7","key":"2026090102362528900_cit1","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1111\/jdv.18012","article-title":"Global epidemiology of alopecia and acne: Burden and quality of life impact","volume":"36","author":"Tan","year":"2022","journal-title":"J. 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